Association between Serum Zinc Levels and Clinical Index or the Body Composition in Incident Hemodialysis Patients
Background: The relationships between serum zinc levels and body composition or clinical outcomes of incident hemodialysis (HD) patients remain unclear. Methods: This prospective observational study examined the relationships between serum zinc levels and clinical indexes, including body composition...
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MDPI AG
2020-10-01
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Online Access: | https://www.mdpi.com/2072-6643/12/10/3187 |
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author | Tatsunori Toida Reiko Toida Shou Ebihara Risa Takahashi Hiroyuki Komatsu Shigehiro Uezono Yuji Sato Shouichi Fujimoto |
author_facet | Tatsunori Toida Reiko Toida Shou Ebihara Risa Takahashi Hiroyuki Komatsu Shigehiro Uezono Yuji Sato Shouichi Fujimoto |
author_sort | Tatsunori Toida |
collection | DOAJ |
description | Background: The relationships between serum zinc levels and body composition or clinical outcomes of incident hemodialysis (HD) patients remain unclear. Methods: This prospective observational study examined the relationships between serum zinc levels and clinical indexes, including body composition, in 142 incident HD patients using a bioelectrical impedance analysis. Patients were divided into three groups according to baseline serum zinc levels: tertile, <45, 45–59, and ≥60 µg/dL. The reference group was set as ≥60 µg/dL. Cox’s regression analysis was performed to investigate the relationships between serum zinc categories and cardiovascular events and all-cause mortality after adjustments for potential confounders. Results: Serum zinc levels positively correlated with the nutritional index and negatively correlated with fluid volume markers. In a mean follow-up of 2.5 years, there were 20 cases of cardiovascular events and 15 of all-cause mortality. In the Cox’s regression analysis for cardiovascular events and all-cause mortality, the hazard ratio increased with a decrease in serum zinc levels, but was not significant. Conclusion: Serum zinc levels were associated with nutritional and fluid volume markers in incident HD patients. To clarify the relationship between serum zinc levels and cardiovascular events or mortality, further studies with a larger number of cases will be necessary. |
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format | Article |
id | doaj.art-a94903aeac384140b6e7413148437b32 |
institution | Directory Open Access Journal |
issn | 2072-6643 |
language | English |
last_indexed | 2024-03-10T15:31:45Z |
publishDate | 2020-10-01 |
publisher | MDPI AG |
record_format | Article |
series | Nutrients |
spelling | doaj.art-a94903aeac384140b6e7413148437b322023-11-20T17:36:34ZengMDPI AGNutrients2072-66432020-10-011210318710.3390/nu12103187Association between Serum Zinc Levels and Clinical Index or the Body Composition in Incident Hemodialysis PatientsTatsunori Toida0Reiko Toida1Shou Ebihara2Risa Takahashi3Hiroyuki Komatsu4Shigehiro Uezono5Yuji Sato6Shouichi Fujimoto7Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1692, JapanDepartment of Internal Medicine, Chiyoda Hospital, Hyuga 883-0064, JapanDivision of Circulatory and Body Fluid Regulation, Department of Internal Medicine, University of Miyazaki, Miyazaki 889-1692, JapanDepartment of Internal Medicine, Miyazaki Prefectural Nobeoka Hospital, Nobeoka 882-0835, JapanCenter for Medical Education and Career Development, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1692, JapanDepartment of Internal Medicine, Chiyoda Hospital, Hyuga 883-0064, JapanDivision of Nephrology, Department of Internal Medicine, National Health Insurance Takachiho Town Hospital, Takachiho 882-1101, JapanDepartment of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1692, JapanBackground: The relationships between serum zinc levels and body composition or clinical outcomes of incident hemodialysis (HD) patients remain unclear. Methods: This prospective observational study examined the relationships between serum zinc levels and clinical indexes, including body composition, in 142 incident HD patients using a bioelectrical impedance analysis. Patients were divided into three groups according to baseline serum zinc levels: tertile, <45, 45–59, and ≥60 µg/dL. The reference group was set as ≥60 µg/dL. Cox’s regression analysis was performed to investigate the relationships between serum zinc categories and cardiovascular events and all-cause mortality after adjustments for potential confounders. Results: Serum zinc levels positively correlated with the nutritional index and negatively correlated with fluid volume markers. In a mean follow-up of 2.5 years, there were 20 cases of cardiovascular events and 15 of all-cause mortality. In the Cox’s regression analysis for cardiovascular events and all-cause mortality, the hazard ratio increased with a decrease in serum zinc levels, but was not significant. Conclusion: Serum zinc levels were associated with nutritional and fluid volume markers in incident HD patients. To clarify the relationship between serum zinc levels and cardiovascular events or mortality, further studies with a larger number of cases will be necessary.https://www.mdpi.com/2072-6643/12/10/3187serum zinc levelshemodialysisnutritional status |
spellingShingle | Tatsunori Toida Reiko Toida Shou Ebihara Risa Takahashi Hiroyuki Komatsu Shigehiro Uezono Yuji Sato Shouichi Fujimoto Association between Serum Zinc Levels and Clinical Index or the Body Composition in Incident Hemodialysis Patients Nutrients serum zinc levels hemodialysis nutritional status |
title | Association between Serum Zinc Levels and Clinical Index or the Body Composition in Incident Hemodialysis Patients |
title_full | Association between Serum Zinc Levels and Clinical Index or the Body Composition in Incident Hemodialysis Patients |
title_fullStr | Association between Serum Zinc Levels and Clinical Index or the Body Composition in Incident Hemodialysis Patients |
title_full_unstemmed | Association between Serum Zinc Levels and Clinical Index or the Body Composition in Incident Hemodialysis Patients |
title_short | Association between Serum Zinc Levels and Clinical Index or the Body Composition in Incident Hemodialysis Patients |
title_sort | association between serum zinc levels and clinical index or the body composition in incident hemodialysis patients |
topic | serum zinc levels hemodialysis nutritional status |
url | https://www.mdpi.com/2072-6643/12/10/3187 |
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