Vanishing bile duct syndrome in a hodgkin′s lymphoma patient with fatal outcome despite lymphoma remission
Vanishing bile duct syndrome (VBDS) is a condition resulting from severe bile duct injury, progressive destruction, and disappearance of intrahepatic bile ducts (ductopenia) leading to cholestasis, biliary cirrhosis, and liver failure. VBDS can be associated with a variety of disorders, including Ho...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2013-01-01
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| Series: | The Saudi Journal of Gastroenterology |
| Subjects: | |
| Online Access: | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2013;volume=19;issue=6;spage=286;epage=289;aulast=Aleem |
| _version_ | 1818153980843261952 |
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| author | Aamer Aleem Mohammad Al-Katari Khalid Alsaleh Khalid AlSwat Abdulmalik Al-Sheikh |
| author_facet | Aamer Aleem Mohammad Al-Katari Khalid Alsaleh Khalid AlSwat Abdulmalik Al-Sheikh |
| author_sort | Aamer Aleem |
| collection | DOAJ |
| description | Vanishing bile duct syndrome (VBDS) is a condition resulting from severe bile duct injury, progressive destruction, and disappearance of intrahepatic bile ducts (ductopenia) leading to cholestasis, biliary cirrhosis, and liver failure. VBDS can be associated with a variety of disorders, including Hodgkin′s lymphoma (HL). We describe a 33-year-old male patient who presented with lymphadenopathy and jaundice, and was diagnosed to have HL. Serum bilirubin worsened progressively despite chemotherapy, with a cholestatic pattern of liver enzymes. Diagnosis of VBDS was established on liver biopsy. Although remission from HL was achieved, the patient died of liver failure. Presence of jaundice in HL patients should raise the possibility of VBDS. This report discusses the difficulties of delivering chemotherapy in patients with liver dysfunction. HL-associated VBDS carries a high mortality but lymphoma remission can be achieved in some patients. Therefore, liver transplantation should be considered early in these patients. |
| first_indexed | 2024-12-11T14:19:14Z |
| format | Article |
| id | doaj.art-a949fcd3253d4c09aa7e02fd4bc495d4 |
| institution | Directory Open Access Journal |
| issn | 1319-3767 1998-4049 |
| language | English |
| last_indexed | 2024-12-11T14:19:14Z |
| publishDate | 2013-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | The Saudi Journal of Gastroenterology |
| spelling | doaj.art-a949fcd3253d4c09aa7e02fd4bc495d42022-12-22T01:03:00ZengWolters Kluwer Medknow PublicationsThe Saudi Journal of Gastroenterology1319-37671998-40492013-01-0119628628910.4103/1319-3767.121037Vanishing bile duct syndrome in a hodgkin′s lymphoma patient with fatal outcome despite lymphoma remissionAamer AleemMohammad Al-KatariKhalid AlsalehKhalid AlSwatAbdulmalik Al-SheikhVanishing bile duct syndrome (VBDS) is a condition resulting from severe bile duct injury, progressive destruction, and disappearance of intrahepatic bile ducts (ductopenia) leading to cholestasis, biliary cirrhosis, and liver failure. VBDS can be associated with a variety of disorders, including Hodgkin′s lymphoma (HL). We describe a 33-year-old male patient who presented with lymphadenopathy and jaundice, and was diagnosed to have HL. Serum bilirubin worsened progressively despite chemotherapy, with a cholestatic pattern of liver enzymes. Diagnosis of VBDS was established on liver biopsy. Although remission from HL was achieved, the patient died of liver failure. Presence of jaundice in HL patients should raise the possibility of VBDS. This report discusses the difficulties of delivering chemotherapy in patients with liver dysfunction. HL-associated VBDS carries a high mortality but lymphoma remission can be achieved in some patients. Therefore, liver transplantation should be considered early in these patients.http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2013;volume=19;issue=6;spage=286;epage=289;aulast=AleemChemotherapyHodgkin′s lymphomavanishing bile duct syndrome |
| spellingShingle | Aamer Aleem Mohammad Al-Katari Khalid Alsaleh Khalid AlSwat Abdulmalik Al-Sheikh Vanishing bile duct syndrome in a hodgkin′s lymphoma patient with fatal outcome despite lymphoma remission The Saudi Journal of Gastroenterology Chemotherapy Hodgkin′s lymphoma vanishing bile duct syndrome |
| title | Vanishing bile duct syndrome in a hodgkin′s lymphoma patient with fatal outcome despite lymphoma remission |
| title_full | Vanishing bile duct syndrome in a hodgkin′s lymphoma patient with fatal outcome despite lymphoma remission |
| title_fullStr | Vanishing bile duct syndrome in a hodgkin′s lymphoma patient with fatal outcome despite lymphoma remission |
| title_full_unstemmed | Vanishing bile duct syndrome in a hodgkin′s lymphoma patient with fatal outcome despite lymphoma remission |
| title_short | Vanishing bile duct syndrome in a hodgkin′s lymphoma patient with fatal outcome despite lymphoma remission |
| title_sort | vanishing bile duct syndrome in a hodgkin s lymphoma patient with fatal outcome despite lymphoma remission |
| topic | Chemotherapy Hodgkin′s lymphoma vanishing bile duct syndrome |
| url | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2013;volume=19;issue=6;spage=286;epage=289;aulast=Aleem |
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