Proteomic profiling reveals mitochondrial dysfunction in the cerebellum of transgenic mice overexpressing DYRK1A, a Down syndrome candidate gene

Proteomic profiling reveals mitochondrial dysfunction in the cerebellum of transgenic mice overexpressing DYRK1A, a Down syndrome candidate gene

IntroductionDYRK1A is a dual-specificity kinase that is overexpressed in Down syndrome (DS) and plays a key role in neurogenesis, neuronal differentiation and function, cognitive phenotypes, and aging. Dyrk1A has also been implicated in cerebellar abnormalities observed in association with DS, and n...

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Bibliographic Details
Main Authors: Mireia Ortega, Ilario De Toma, Álvaro Fernández-Blanco, Anna Calderón, Lucía Barahona, Ramón Trullàs, Eduard Sabidó, Mara Dierssen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
DYRK1A
cerebellum
mitochondria
oxidative phosphorylation system
Down syndrome
proteomics
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.1015220/full

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