Technology for test-systems for diagnosis of modified proteins (proteopathy) underlying social diseases (Report 1)
A new experimental technique for obtaining diagnostic test systems is introduced based on conjugates "polymer microsphere–bioligand" for rapid diagnosis of autoantibodies to the modified protein on example of thyroglobulin, which consists of preliminary blocking of aldehyde groups of polym...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
MIREA - Russian Technological University
2013-06-01
|
| Series: | Тонкие химические технологии |
| Subjects: | |
| Online Access: | https://www.finechem-mirea.ru/jour/article/view/597 |
| _version_ | 1826565796983209984 |
|---|---|
| author | Ya. M. Stanishevskiy I. A. Gritskova N. S. Kuzmina |
| author_facet | Ya. M. Stanishevskiy I. A. Gritskova N. S. Kuzmina |
| author_sort | Ya. M. Stanishevskiy |
| collection | DOAJ |
| description | A new experimental technique for obtaining diagnostic test systems is introduced based on conjugates "polymer microsphere–bioligand" for rapid diagnosis of autoantibodies to the modified protein on example of thyroglobulin, which consists of preliminary blocking of aldehyde groups of polymer microspheres by glycine amine groups, and then of the covalent interaction between carboxyl group of glycine and the amino groups of thyroglobulin. This way of creating test systems has enhanced the sensitivity of the reaction of latex agglutination (RLA) by extending the boundaries of titer. |
| first_indexed | 2024-04-10T03:30:02Z |
| format | Article |
| id | doaj.art-a94b0b327078488db12dda122e5f76fb |
| institution | Directory Open Access Journal |
| issn | 2410-6593 2686-7575 |
| language | Russian |
| last_indexed | 2025-03-14T10:41:27Z |
| publishDate | 2013-06-01 |
| publisher | MIREA - Russian Technological University |
| record_format | Article |
| series | Тонкие химические технологии |
| spelling | doaj.art-a94b0b327078488db12dda122e5f76fb2025-03-02T10:57:30ZrusMIREA - Russian Technological UniversityТонкие химические технологии2410-65932686-75752013-06-01838794591Technology for test-systems for diagnosis of modified proteins (proteopathy) underlying social diseases (Report 1)Ya. M. Stanishevskiy0I. A. Gritskova1N. S. Kuzmina2M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571Mechnikov Research Institute of Vaccines and Sera, Moscow, 105064A new experimental technique for obtaining diagnostic test systems is introduced based on conjugates "polymer microsphere–bioligand" for rapid diagnosis of autoantibodies to the modified protein on example of thyroglobulin, which consists of preliminary blocking of aldehyde groups of polymer microspheres by glycine amine groups, and then of the covalent interaction between carboxyl group of glycine and the amino groups of thyroglobulin. This way of creating test systems has enhanced the sensitivity of the reaction of latex agglutination (RLA) by extending the boundaries of titer.https://www.finechem-mirea.ru/jour/article/view/597diagnostic test system, the polymer suspension, thyroglobulin, latex agglutination reaction. |
| spellingShingle | Ya. M. Stanishevskiy I. A. Gritskova N. S. Kuzmina Technology for test-systems for diagnosis of modified proteins (proteopathy) underlying social diseases (Report 1) Тонкие химические технологии diagnostic test system, the polymer suspension, thyroglobulin, latex agglutination reaction. |
| title | Technology for test-systems for diagnosis of modified proteins (proteopathy) underlying social diseases (Report 1) |
| title_full | Technology for test-systems for diagnosis of modified proteins (proteopathy) underlying social diseases (Report 1) |
| title_fullStr | Technology for test-systems for diagnosis of modified proteins (proteopathy) underlying social diseases (Report 1) |
| title_full_unstemmed | Technology for test-systems for diagnosis of modified proteins (proteopathy) underlying social diseases (Report 1) |
| title_short | Technology for test-systems for diagnosis of modified proteins (proteopathy) underlying social diseases (Report 1) |
| title_sort | technology for test systems for diagnosis of modified proteins proteopathy underlying social diseases report 1 |
| topic | diagnostic test system, the polymer suspension, thyroglobulin, latex agglutination reaction. |
| url | https://www.finechem-mirea.ru/jour/article/view/597 |
| work_keys_str_mv | AT yamstanishevskiy technologyfortestsystemsfordiagnosisofmodifiedproteinsproteopathyunderlyingsocialdiseasesreport1 AT iagritskova technologyfortestsystemsfordiagnosisofmodifiedproteinsproteopathyunderlyingsocialdiseasesreport1 AT nskuzmina technologyfortestsystemsfordiagnosisofmodifiedproteinsproteopathyunderlyingsocialdiseasesreport1 |