An implantable helmet for studying repeat TBI
An estimated 3.8 million traumatic brain injuries (TBI) occur each year, the majority classified as mild. Interest in models of mild and repeat mild TBI has grown due to reports of lasting morbidity following sports- or combat-related injury. There remains a paucity of data linking cellular or syste...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | MethodsX |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2215016120303629 |
| _version_ | 1818325451518509056 |
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| author | Katelynn Ondek Steven Lucero Marike Zwienenberg Gene Gurkoff |
| author_facet | Katelynn Ondek Steven Lucero Marike Zwienenberg Gene Gurkoff |
| author_sort | Katelynn Ondek |
| collection | DOAJ |
| description | An estimated 3.8 million traumatic brain injuries (TBI) occur each year, the majority classified as mild. Interest in models of mild and repeat mild TBI has grown due to reports of lasting morbidity following sports- or combat-related injury. There remains a paucity of data linking cellular or systems-related mechanisms to behavioral outcomes following repeat mild TBI, particularly in adolescent and adult rats. It is critical, therefore, to develop flexible models to evaluate which parameters of injury are associated with brain vulnerability or poor chronic outcome compared to normal recovery. While there are several existing models of repeat mild TBI in rodents, studying the effects of multiple hits has been complicated by the need for multiple survival surgeries, extensive pre-injury anesthesia time, and limitations due to animal skull thickness. • We developed a chronic “helmet” implant by combining aspects of the Impact Acceleration and Controlled Cortical Impact models. • Implants were performed days before injury, allowing us to decouple surgery from TBI. Critically, by pre-implanting the animals, only minimal anesthesia was required to position them under the impactor. • The implant allows for flexibility in the number and severity of injuries and interval between impacts. |
| first_indexed | 2024-12-13T11:44:41Z |
| format | Article |
| id | doaj.art-a94b187cf9fe499ab486bb181707d1ec |
| institution | Directory Open Access Journal |
| issn | 2215-0161 |
| language | English |
| last_indexed | 2024-12-13T11:44:41Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | MethodsX |
| spelling | doaj.art-a94b187cf9fe499ab486bb181707d1ec2022-12-21T23:47:33ZengElsevierMethodsX2215-01612020-01-017101142An implantable helmet for studying repeat TBIKatelynn Ondek0Steven Lucero1Marike Zwienenberg2Gene Gurkoff3Department of Neurological Surgery, University of California, 1515 Newton Ct, Davis, CA 95618, United StatesDepartment of Biomedical Engineering, University of California, Davis, CA 95618, United StatesDepartment of Neurological Surgery, University of California, 1515 Newton Ct, Davis, CA 95618, United StatesDepartment of Neurological Surgery, University of California, 1515 Newton Ct, Davis, CA 95618, United States; Corresponding author.An estimated 3.8 million traumatic brain injuries (TBI) occur each year, the majority classified as mild. Interest in models of mild and repeat mild TBI has grown due to reports of lasting morbidity following sports- or combat-related injury. There remains a paucity of data linking cellular or systems-related mechanisms to behavioral outcomes following repeat mild TBI, particularly in adolescent and adult rats. It is critical, therefore, to develop flexible models to evaluate which parameters of injury are associated with brain vulnerability or poor chronic outcome compared to normal recovery. While there are several existing models of repeat mild TBI in rodents, studying the effects of multiple hits has been complicated by the need for multiple survival surgeries, extensive pre-injury anesthesia time, and limitations due to animal skull thickness. • We developed a chronic “helmet” implant by combining aspects of the Impact Acceleration and Controlled Cortical Impact models. • Implants were performed days before injury, allowing us to decouple surgery from TBI. Critically, by pre-implanting the animals, only minimal anesthesia was required to position them under the impactor. • The implant allows for flexibility in the number and severity of injuries and interval between impacts.http://www.sciencedirect.com/science/article/pii/S2215016120303629Repeat injurySports injurymTBI |
| spellingShingle | Katelynn Ondek Steven Lucero Marike Zwienenberg Gene Gurkoff An implantable helmet for studying repeat TBI MethodsX Repeat injury Sports injury mTBI |
| title | An implantable helmet for studying repeat TBI |
| title_full | An implantable helmet for studying repeat TBI |
| title_fullStr | An implantable helmet for studying repeat TBI |
| title_full_unstemmed | An implantable helmet for studying repeat TBI |
| title_short | An implantable helmet for studying repeat TBI |
| title_sort | implantable helmet for studying repeat tbi |
| topic | Repeat injury Sports injury mTBI |
| url | http://www.sciencedirect.com/science/article/pii/S2215016120303629 |
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