Scrotal hemorrhage after testicular sperm aspiration may be associated with phosphodiesterase-5 inhibitor administration: a retrospective study
Abstract Background Scrotal hemorrhage after testicular sperm aspiration (TESA) is uncommon in clinical operation. Phosphodiesterase-5 inhibitors (PDE5i) are commonly given to men who have difficulty providing a sperm sample for assisted reproductive technique such as in vitro fertilization. In this...
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BMC
2018-02-01
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| Series: | BMC Urology |
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| Online Access: | http://link.springer.com/article/10.1186/s12894-018-0316-9 |
| _version_ | 1818419403879874560 |
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| author | Yong-tong Zhu Rui Hua Song Quan Wan-long Tan Qing-jun Chu Chun-yan Wang |
| author_facet | Yong-tong Zhu Rui Hua Song Quan Wan-long Tan Qing-jun Chu Chun-yan Wang |
| author_sort | Yong-tong Zhu |
| collection | DOAJ |
| description | Abstract Background Scrotal hemorrhage after testicular sperm aspiration (TESA) is uncommon in clinical operation. Phosphodiesterase-5 inhibitors (PDE5i) are commonly given to men who have difficulty providing a sperm sample for assisted reproductive technique such as in vitro fertilization. In this study, we examine the incidence of scrotal hemorrhage after TESA in men who received a PDE5i. Methods In this retrospective study, 504 men with TESA operation in Center for Reproductive Medicine, Nanfang Hospital, Southern Medical University were collected. Men in the drug group had taken orally PDE5i before TESA. Men in the control group only operated TESA. The testis volume, coagulation function were measured. Sonographic examination with Doppler imaging was performed when scrotal hemorrhage appeared. Results A total of 504 men with a mean age of 28.63 ± 4.22 years were included in the analysis. Of these, 428 did not receive a PDE5i prior to TESA and 76 received a PDE5i prior to TESA. Measures of coagulation function were not different between the groups. The incidence of hemorrhage was 0.0% in the control group and the drug group was 5.3%. The incidence of hemorrhage between two groups was different significantly (P = 0.000). Conclusion In summary, the results of this study suggest that a PDE5i administration increases the risk of scrotal hemorrhage in men undergoing TESA, although the study design does not allow drawing a conclusion of cause and effect. Given the potential risk of scrotal hemorrhage after the ingestion of PDE5i, it may be wise not to administer it to men in whom a TESA may be performed. |
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| format | Article |
| id | doaj.art-a94bf432ee8f4b23917f4b9027b15435 |
| institution | Directory Open Access Journal |
| issn | 1471-2490 |
| language | English |
| last_indexed | 2024-12-14T12:38:01Z |
| publishDate | 2018-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Urology |
| spelling | doaj.art-a94bf432ee8f4b23917f4b9027b154352022-12-21T23:00:59ZengBMCBMC Urology1471-24902018-02-011811410.1186/s12894-018-0316-9Scrotal hemorrhage after testicular sperm aspiration may be associated with phosphodiesterase-5 inhibitor administration: a retrospective studyYong-tong Zhu0Rui Hua1Song Quan2Wan-long Tan3Qing-jun Chu4Chun-yan Wang5Reproductive Medicine Center, Department of Obstetrics and Gynecology, Nanfang Hospital/ The First School of Clinical Medicine, Southern Medical UniversityReproductive Medicine Center, Department of Obstetrics and Gynecology, Nanfang Hospital/ The First School of Clinical Medicine, Southern Medical UniversityReproductive Medicine Center, Department of Obstetrics and Gynecology, Nanfang Hospital/ The First School of Clinical Medicine, Southern Medical UniversityDepartment of Urology, Nanfang Hospital, Southern Medical UniversityReproductive Medicine Center, Department of Obstetrics and Gynecology, Nanfang Hospital/ The First School of Clinical Medicine, Southern Medical UniversityDepartment of Neurology, Integrated Hospital of Traditional Chinese Medicine, Southern Medical UniversityAbstract Background Scrotal hemorrhage after testicular sperm aspiration (TESA) is uncommon in clinical operation. Phosphodiesterase-5 inhibitors (PDE5i) are commonly given to men who have difficulty providing a sperm sample for assisted reproductive technique such as in vitro fertilization. In this study, we examine the incidence of scrotal hemorrhage after TESA in men who received a PDE5i. Methods In this retrospective study, 504 men with TESA operation in Center for Reproductive Medicine, Nanfang Hospital, Southern Medical University were collected. Men in the drug group had taken orally PDE5i before TESA. Men in the control group only operated TESA. The testis volume, coagulation function were measured. Sonographic examination with Doppler imaging was performed when scrotal hemorrhage appeared. Results A total of 504 men with a mean age of 28.63 ± 4.22 years were included in the analysis. Of these, 428 did not receive a PDE5i prior to TESA and 76 received a PDE5i prior to TESA. Measures of coagulation function were not different between the groups. The incidence of hemorrhage was 0.0% in the control group and the drug group was 5.3%. The incidence of hemorrhage between two groups was different significantly (P = 0.000). Conclusion In summary, the results of this study suggest that a PDE5i administration increases the risk of scrotal hemorrhage in men undergoing TESA, although the study design does not allow drawing a conclusion of cause and effect. Given the potential risk of scrotal hemorrhage after the ingestion of PDE5i, it may be wise not to administer it to men in whom a TESA may be performed.http://link.springer.com/article/10.1186/s12894-018-0316-9Scrotal hemorrhageTesticular sperm aspirationPhosphodiesterase-5 inhibitor |
| spellingShingle | Yong-tong Zhu Rui Hua Song Quan Wan-long Tan Qing-jun Chu Chun-yan Wang Scrotal hemorrhage after testicular sperm aspiration may be associated with phosphodiesterase-5 inhibitor administration: a retrospective study BMC Urology Scrotal hemorrhage Testicular sperm aspiration Phosphodiesterase-5 inhibitor |
| title | Scrotal hemorrhage after testicular sperm aspiration may be associated with phosphodiesterase-5 inhibitor administration: a retrospective study |
| title_full | Scrotal hemorrhage after testicular sperm aspiration may be associated with phosphodiesterase-5 inhibitor administration: a retrospective study |
| title_fullStr | Scrotal hemorrhage after testicular sperm aspiration may be associated with phosphodiesterase-5 inhibitor administration: a retrospective study |
| title_full_unstemmed | Scrotal hemorrhage after testicular sperm aspiration may be associated with phosphodiesterase-5 inhibitor administration: a retrospective study |
| title_short | Scrotal hemorrhage after testicular sperm aspiration may be associated with phosphodiesterase-5 inhibitor administration: a retrospective study |
| title_sort | scrotal hemorrhage after testicular sperm aspiration may be associated with phosphodiesterase 5 inhibitor administration a retrospective study |
| topic | Scrotal hemorrhage Testicular sperm aspiration Phosphodiesterase-5 inhibitor |
| url | http://link.springer.com/article/10.1186/s12894-018-0316-9 |
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