Antioxidant Nanozymes: Mechanisms, Activity Manipulation, and Applications
Antioxidant enzymes such as catalase, superoxide dismutase, and glutathione peroxidase play important roles in the inhibition of oxidative-damage-related pathological diseases. However, natural antioxidant enzymes face some limitations, including low stability, high cost, and less flexibility. Recen...
| 主要な著者: | , , , , , |
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| フォーマット: | 論文 |
| 言語: | English |
| 出版事項: |
MDPI AG
2023-05-01
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| シリーズ: | Micromachines |
| 主題: | |
| オンライン･アクセス: | https://www.mdpi.com/2072-666X/14/5/1017 |
| _version_ | 1827740660061437952 |
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| author | Nguyen Thi My Thao Hoang Dang Khoa Do Nguyen Nhat Nam Nguyen Khoi Song Tran Thach Thi Dan Kieu The Loan Trinh |
| author_facet | Nguyen Thi My Thao Hoang Dang Khoa Do Nguyen Nhat Nam Nguyen Khoi Song Tran Thach Thi Dan Kieu The Loan Trinh |
| author_sort | Nguyen Thi My Thao |
| collection | DOAJ |
| description | Antioxidant enzymes such as catalase, superoxide dismutase, and glutathione peroxidase play important roles in the inhibition of oxidative-damage-related pathological diseases. However, natural antioxidant enzymes face some limitations, including low stability, high cost, and less flexibility. Recently, antioxidant nanozymes have emerged as promising materials to replace natural antioxidant enzymes for their stability, cost savings, and flexible design. The present review firstly discusses the mechanisms of antioxidant nanozymes, focusing on catalase-, superoxide dismutase-, and glutathione peroxidase-like activities. Then, we summarize the main strategies for the manipulation of antioxidant nanozymes based on their size, morphology, composition, surface modification, and modification with a metal-organic framework. Furthermore, the applications of antioxidant nanozymes in medicine and healthcare are also discussed as potential biological applications. In brief, this review provides useful information for the further development of antioxidant nanozymes, offering opportunities to improve current limitations and expand the application of antioxidant nanozymes. |
| first_indexed | 2024-03-11T03:29:24Z |
| format | Article |
| id | doaj.art-a94dd5a18c8847578c757e883316e743 |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-11T03:29:24Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-a94dd5a18c8847578c757e883316e7432023-11-18T02:30:31ZengMDPI AGMicromachines2072-666X2023-05-01145101710.3390/mi14051017Antioxidant Nanozymes: Mechanisms, Activity Manipulation, and ApplicationsNguyen Thi My Thao0Hoang Dang Khoa Do1Nguyen Nhat Nam2Nguyen Khoi Song Tran3Thach Thi Dan4Kieu The Loan Trinh5School of Medicine and Pharmacy, Tra Vinh University, Tra Vinh City 87000, VietnamNTT Hi-Tech Institute, Nguyen Tat Thanh University, Ward 13, District 04, Ho Chi Minh City 70000, VietnamBiotechnology Center, School of Agriculture and Aquaculture, Tra Vinh University, Tra Vinh City 87000, VietnamCollege of Korean Medicine, Gachon University, 1342 Seongnam-daero, Sujeong-gu, Seongnam-si 13120, Republic of KoreaTra Vinh University, Tra Vinh City 87000, VietnamDepartment of BioNano Technology, Gachon University, 1342 Seongnam-daero, Sujeong-gu, Seongnam-si 13120, Republic of KoreaAntioxidant enzymes such as catalase, superoxide dismutase, and glutathione peroxidase play important roles in the inhibition of oxidative-damage-related pathological diseases. However, natural antioxidant enzymes face some limitations, including low stability, high cost, and less flexibility. Recently, antioxidant nanozymes have emerged as promising materials to replace natural antioxidant enzymes for their stability, cost savings, and flexible design. The present review firstly discusses the mechanisms of antioxidant nanozymes, focusing on catalase-, superoxide dismutase-, and glutathione peroxidase-like activities. Then, we summarize the main strategies for the manipulation of antioxidant nanozymes based on their size, morphology, composition, surface modification, and modification with a metal-organic framework. Furthermore, the applications of antioxidant nanozymes in medicine and healthcare are also discussed as potential biological applications. In brief, this review provides useful information for the further development of antioxidant nanozymes, offering opportunities to improve current limitations and expand the application of antioxidant nanozymes.https://www.mdpi.com/2072-666X/14/5/1017antioxidant nanozymecatalasesuperoxide dismutaseglutathione peroxidaseenzymatic manipulation |
| spellingShingle | Nguyen Thi My Thao Hoang Dang Khoa Do Nguyen Nhat Nam Nguyen Khoi Song Tran Thach Thi Dan Kieu The Loan Trinh Antioxidant Nanozymes: Mechanisms, Activity Manipulation, and Applications Micromachines antioxidant nanozyme catalase superoxide dismutase glutathione peroxidase enzymatic manipulation |
| title | Antioxidant Nanozymes: Mechanisms, Activity Manipulation, and Applications |
| title_full | Antioxidant Nanozymes: Mechanisms, Activity Manipulation, and Applications |
| title_fullStr | Antioxidant Nanozymes: Mechanisms, Activity Manipulation, and Applications |
| title_full_unstemmed | Antioxidant Nanozymes: Mechanisms, Activity Manipulation, and Applications |
| title_short | Antioxidant Nanozymes: Mechanisms, Activity Manipulation, and Applications |
| title_sort | antioxidant nanozymes mechanisms activity manipulation and applications |
| topic | antioxidant nanozyme catalase superoxide dismutase glutathione peroxidase enzymatic manipulation |
| url | https://www.mdpi.com/2072-666X/14/5/1017 |
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