The expression and clinical significance of PDCD4 and Her-2 in human gastric cancer
To investigate the correlation and clinical significance between programmed cell death factor 4 (PDCD4) and epidermal growth factor receptor 2 (Her-2) expressions and clinicopathological parameters in patients with gastric cancer, a total of 65 cases of gastric cancer and the corresponding normal mu...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2019-03-01
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| Series: | European Journal of Inflammation |
| Online Access: | https://doi.org/10.1177/2058739219828236 |
| _version_ | 1819168797870784512 |
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| author | Yuelou Yang Xiangjun Jiang Dong Li Feiyan Wang Qun Yang Bin Li |
| author_facet | Yuelou Yang Xiangjun Jiang Dong Li Feiyan Wang Qun Yang Bin Li |
| author_sort | Yuelou Yang |
| collection | DOAJ |
| description | To investigate the correlation and clinical significance between programmed cell death factor 4 (PDCD4) and epidermal growth factor receptor 2 (Her-2) expressions and clinicopathological parameters in patients with gastric cancer, a total of 65 cases of gastric cancer and the corresponding normal mucosa with PDCD4 and Her-2 protein expressions were detected by SP immunohistochemical staining, and 50 cases of gastric cancer and the corresponding normal mucosa with PDCD4 and Her-2 protein expression quantities were detected by Western blot, in order to analyze the relationship between the positive expressions of PDCD4 and Her-2 protein and the clinicopathological features of patients with gastric cancer. The results showed that the positive rate of PDCD4 protein expression in gastric cancer tissues was 7.7%, which was significantly lower than that in the corresponding normal tissues, that is, 77.5% ( P < 0.05); the positive rate of Her-2 expression was 41.5%, which was significantly higher than that of the corresponding normal tissues, which is 2.5% ( P < 0.05). The Western blot test showed that the expression of PDCD4 protein in gastric cancer was 0.3105 ± 0.0073, which was significantly lower than that in the corresponding normal tissues, that is, 0.9428 ± 0.0127 ( P < 0.05); the expression level of Her-2 protein in gastric cancer tissues was 0.9428 ± 0.0127, which was significantly higher than that of the corresponding normal mucosa, which is 0.2054 ± 0.0264 ( P < 0.05). The positive expressions of PDCD4 (5/65) and Her-2 (27/65) were significantly correlated with the differentiation degrees and TNM stages of gastric cancer ( P < 0.05). However, no significant correlation can be observed from Table 2 ( P > 0.05), regarding sex, age, tumor size, and lymph node metastasis. Our research claimed that PDCD4 and Her-2 may play an important role in the invasion and metastasis of gastric cancer, which has a negative correlation with biological behaviors of gastric cancer. The low expression of PDCD4 and the high expression of Her-2 in gastric cancer may promote the occurrence and progression of cancer. The PDCD4 and Her-2 test can be used as an index to evaluate the malignant biological behaviors of gastric cancer and prognosis, and provide a theoretical basis for targeted therapy. |
| first_indexed | 2024-12-22T19:09:19Z |
| format | Article |
| id | doaj.art-a94e2da05d5c4391a15481183d366bc5 |
| institution | Directory Open Access Journal |
| issn | 2058-7392 |
| language | English |
| last_indexed | 2024-12-22T19:09:19Z |
| publishDate | 2019-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | European Journal of Inflammation |
| spelling | doaj.art-a94e2da05d5c4391a15481183d366bc52022-12-21T18:15:43ZengSAGE PublishingEuropean Journal of Inflammation2058-73922019-03-011710.1177/2058739219828236The expression and clinical significance of PDCD4 and Her-2 in human gastric cancerYuelou Yang0Xiangjun Jiang1Dong Li2Feiyan Wang3Qun Yang4Bin Li5Department of Gastroenterology, Qingdao Huangdao District Central Hospital, Qingdao, ChinaDepartment of Gastroenterology, Qingdao Municipal Hospital, Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Pathology, Qingdao Huangdao District Central Hospital, Qingdao, ChinaDepartment of Gastroenterology, Qingdao Huangdao District Central Hospital, Qingdao, ChinaDepartment of Maternity, Qingdao Huangdao District Central Hospital, Qingdao, ChinaDepartment of Gastroenterology, Qingdao Huangdao District Central Hospital, Qingdao, ChinaTo investigate the correlation and clinical significance between programmed cell death factor 4 (PDCD4) and epidermal growth factor receptor 2 (Her-2) expressions and clinicopathological parameters in patients with gastric cancer, a total of 65 cases of gastric cancer and the corresponding normal mucosa with PDCD4 and Her-2 protein expressions were detected by SP immunohistochemical staining, and 50 cases of gastric cancer and the corresponding normal mucosa with PDCD4 and Her-2 protein expression quantities were detected by Western blot, in order to analyze the relationship between the positive expressions of PDCD4 and Her-2 protein and the clinicopathological features of patients with gastric cancer. The results showed that the positive rate of PDCD4 protein expression in gastric cancer tissues was 7.7%, which was significantly lower than that in the corresponding normal tissues, that is, 77.5% ( P < 0.05); the positive rate of Her-2 expression was 41.5%, which was significantly higher than that of the corresponding normal tissues, which is 2.5% ( P < 0.05). The Western blot test showed that the expression of PDCD4 protein in gastric cancer was 0.3105 ± 0.0073, which was significantly lower than that in the corresponding normal tissues, that is, 0.9428 ± 0.0127 ( P < 0.05); the expression level of Her-2 protein in gastric cancer tissues was 0.9428 ± 0.0127, which was significantly higher than that of the corresponding normal mucosa, which is 0.2054 ± 0.0264 ( P < 0.05). The positive expressions of PDCD4 (5/65) and Her-2 (27/65) were significantly correlated with the differentiation degrees and TNM stages of gastric cancer ( P < 0.05). However, no significant correlation can be observed from Table 2 ( P > 0.05), regarding sex, age, tumor size, and lymph node metastasis. Our research claimed that PDCD4 and Her-2 may play an important role in the invasion and metastasis of gastric cancer, which has a negative correlation with biological behaviors of gastric cancer. The low expression of PDCD4 and the high expression of Her-2 in gastric cancer may promote the occurrence and progression of cancer. The PDCD4 and Her-2 test can be used as an index to evaluate the malignant biological behaviors of gastric cancer and prognosis, and provide a theoretical basis for targeted therapy.https://doi.org/10.1177/2058739219828236 |
| spellingShingle | Yuelou Yang Xiangjun Jiang Dong Li Feiyan Wang Qun Yang Bin Li The expression and clinical significance of PDCD4 and Her-2 in human gastric cancer European Journal of Inflammation |
| title | The expression and clinical significance of PDCD4 and Her-2 in human gastric cancer |
| title_full | The expression and clinical significance of PDCD4 and Her-2 in human gastric cancer |
| title_fullStr | The expression and clinical significance of PDCD4 and Her-2 in human gastric cancer |
| title_full_unstemmed | The expression and clinical significance of PDCD4 and Her-2 in human gastric cancer |
| title_short | The expression and clinical significance of PDCD4 and Her-2 in human gastric cancer |
| title_sort | expression and clinical significance of pdcd4 and her 2 in human gastric cancer |
| url | https://doi.org/10.1177/2058739219828236 |
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