Total Synthesis of Marine-Derived Azole Resistant Antifungal Agent (–)-Melearoride A and Antibiotic (–)-PF1163B
A flexible stereoselective and convergent cum divergent approach to the synthesis of two 13-membered macrolides through a common skeleton present in their structure is described featuring two different routes, with good overall yield. The key synthetic reactions utilized include Keck allylation, Eva...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Georg Thieme Verlag KG
2022-10-01
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| Series: | SynOpen |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/a-1942-6969 |
| _version_ | 1811342669722419200 |
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| author | Bharath Kumar Yasam Srihari Pabbaraja |
| author_facet | Bharath Kumar Yasam Srihari Pabbaraja |
| author_sort | Bharath Kumar Yasam |
| collection | DOAJ |
| description | A flexible stereoselective and convergent cum divergent approach to the synthesis of two 13-membered macrolides through a common skeleton present in their structure is described featuring two different routes, with good overall yield. The key synthetic reactions utilized include Keck allylation, Evans asymmetric methylation, Grubbs metathesis, and Julia–Kocienski olefination. |
| first_indexed | 2024-04-13T19:14:55Z |
| format | Article |
| id | doaj.art-a94f284f65e14367997522a88aa17046 |
| institution | Directory Open Access Journal |
| issn | 2509-9396 |
| language | English |
| last_indexed | 2024-04-13T19:14:55Z |
| publishDate | 2022-10-01 |
| publisher | Georg Thieme Verlag KG |
| record_format | Article |
| series | SynOpen |
| spelling | doaj.art-a94f284f65e14367997522a88aa170462022-12-22T02:33:42ZengGeorg Thieme Verlag KGSynOpen2509-93962022-10-01060422723710.1055/a-1942-6969Total Synthesis of Marine-Derived Azole Resistant Antifungal Agent (–)-Melearoride A and Antibiotic (–)-PF1163BBharath Kumar Yasam0Srihari Pabbaraja1Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical TechnologyDepartment of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical TechnologyA flexible stereoselective and convergent cum divergent approach to the synthesis of two 13-membered macrolides through a common skeleton present in their structure is described featuring two different routes, with good overall yield. The key synthetic reactions utilized include Keck allylation, Evans asymmetric methylation, Grubbs metathesis, and Julia–Kocienski olefination.http://www.thieme-connect.de/DOI/DOI?10.1055/a-1942-6969macrolidesmelearoride apf1163bjulia–kocienski olefinationring-closing metathesis |
| spellingShingle | Bharath Kumar Yasam Srihari Pabbaraja Total Synthesis of Marine-Derived Azole Resistant Antifungal Agent (–)-Melearoride A and Antibiotic (–)-PF1163B SynOpen macrolides melearoride a pf1163b julia–kocienski olefination ring-closing metathesis |
| title | Total Synthesis of Marine-Derived Azole Resistant Antifungal Agent (–)-Melearoride A and Antibiotic (–)-PF1163B |
| title_full | Total Synthesis of Marine-Derived Azole Resistant Antifungal Agent (–)-Melearoride A and Antibiotic (–)-PF1163B |
| title_fullStr | Total Synthesis of Marine-Derived Azole Resistant Antifungal Agent (–)-Melearoride A and Antibiotic (–)-PF1163B |
| title_full_unstemmed | Total Synthesis of Marine-Derived Azole Resistant Antifungal Agent (–)-Melearoride A and Antibiotic (–)-PF1163B |
| title_short | Total Synthesis of Marine-Derived Azole Resistant Antifungal Agent (–)-Melearoride A and Antibiotic (–)-PF1163B |
| title_sort | total synthesis of marine derived azole resistant antifungal agent melearoride a and antibiotic pf1163b |
| topic | macrolides melearoride a pf1163b julia–kocienski olefination ring-closing metathesis |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/a-1942-6969 |
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