Impact of Drug Information Services on Promotion of Rational Use of Antimicrobial Agents: A Descriptive Retrospective Study
Introduction: Drug Information Services (DIS) is dedicated to provide information about drugs and pharmacotherapy, on request from health care professionals, organisations or patients. World Health Organisation (WHO) recommends DIS to promote rational use of medicines. Aim: The study was done t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2021-05-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://www.jcdr.net/articles/PDF/14916/49002_CE[Ra1]_F[SK]_PF1(AKA_SL)_PFA(AKA_KM)_PN(KM).pdf |
| _version_ | 1818740107206721536 |
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| author | Soanker Radhika MVS Subbalaxmi Butul Maleha Pingali Usharani |
| author_facet | Soanker Radhika MVS Subbalaxmi Butul Maleha Pingali Usharani |
| author_sort | Soanker Radhika |
| collection | DOAJ |
| description | Introduction: Drug Information Services (DIS) is dedicated
to provide information about drugs and pharmacotherapy,
on request from health care professionals, organisations or
patients. World Health Organisation (WHO) recommends DIS to
promote rational use of medicines.
Aim: The study was done to understand the impact of DIS on
promotion of rational use of antimicrobial agents, at a tertiary
care hospital.
Materials and Methods: In this retrospective descriptive
study, 126 cases with infection related medication issues
requiring opinion related to appropriate antimicrobial therapy
from January 2014-June 2018 were included and studied in
September 2018. Data related to culture/susceptibility results,
treatment offered, reason for referral and suggestions given by
the DIS captured in the case details form were analysed. The
number of antimicrobials prescribed per case before and after
DIS opinion was compared using paired t-test.
Results: Of the 126 cases (mean age: 35±18.2 years), 82
were culture positive, of which 43 samples reported MultiDrug Resistant (MDR) organisms. Of 126 case referrals, 53
(42.1%) were regarding opinion on appropriate antimicrobial
therapy, 18 (14.3%) for suspected ADRs and rechallenge
opinion, 27 (21.5%) for dosage adjustment of antimicrobials
and 12 (9.5%) for suspected drug-drug interactions. Based
on DIS recommendations, mean number of antimicrobials
prescribed per patient reduced from 3.4±1.85 to 1.62±1.38
(p<0.0001) when tested by paired t-test. Sixteen culturenegative cases were referred for opinion on appropriate
antimicrobial therapy.
Conclusion: DIS is a very useful resource, which provides
unbiased, factual drug information to clinicians and patients and
must be established in all healthcare facilities. DIS strengthen
rational use of antimicrobials. |
| first_indexed | 2024-12-18T01:35:28Z |
| format | Article |
| id | doaj.art-a94fd74f61a94d99b3b9df761075062e |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-18T01:35:28Z |
| publishDate | 2021-05-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-a94fd74f61a94d99b3b9df761075062e2022-12-21T21:25:28ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2021-05-01155FC01FC0410.7860/JCDR/2021/49002.14916Impact of Drug Information Services on Promotion of Rational Use of Antimicrobial Agents: A Descriptive Retrospective StudySoanker Radhika0MVS Subbalaxmi1Butul Maleha2 Pingali Usharani3Associate Professor, Department of Clinical Pharmacology and Therapeutics, Nizam’s Institute of Medical Sciences, Hyderabad, Telangana, India.Additional Professor, Department of General Medicine, Nizam’s Institute of Medical Sciences, Hyderabad, Telangana, India.Ex Resident, Department of Clinical Pharmacology and Therapeutics, Nizam’s Institute of Medical Sciences, Hyderabad, Telangana, India.Professor and Head, Department of Clinical Pharmacology and Therapeutics, Nizam’s Institute of Medical Sciences, Hyderabad, Telangana, India.Introduction: Drug Information Services (DIS) is dedicated to provide information about drugs and pharmacotherapy, on request from health care professionals, organisations or patients. World Health Organisation (WHO) recommends DIS to promote rational use of medicines. Aim: The study was done to understand the impact of DIS on promotion of rational use of antimicrobial agents, at a tertiary care hospital. Materials and Methods: In this retrospective descriptive study, 126 cases with infection related medication issues requiring opinion related to appropriate antimicrobial therapy from January 2014-June 2018 were included and studied in September 2018. Data related to culture/susceptibility results, treatment offered, reason for referral and suggestions given by the DIS captured in the case details form were analysed. The number of antimicrobials prescribed per case before and after DIS opinion was compared using paired t-test. Results: Of the 126 cases (mean age: 35±18.2 years), 82 were culture positive, of which 43 samples reported MultiDrug Resistant (MDR) organisms. Of 126 case referrals, 53 (42.1%) were regarding opinion on appropriate antimicrobial therapy, 18 (14.3%) for suspected ADRs and rechallenge opinion, 27 (21.5%) for dosage adjustment of antimicrobials and 12 (9.5%) for suspected drug-drug interactions. Based on DIS recommendations, mean number of antimicrobials prescribed per patient reduced from 3.4±1.85 to 1.62±1.38 (p<0.0001) when tested by paired t-test. Sixteen culturenegative cases were referred for opinion on appropriate antimicrobial therapy. Conclusion: DIS is a very useful resource, which provides unbiased, factual drug information to clinicians and patients and must be established in all healthcare facilities. DIS strengthen rational use of antimicrobials.https://www.jcdr.net/articles/PDF/14916/49002_CE[Ra1]_F[SK]_PF1(AKA_SL)_PFA(AKA_KM)_PN(KM).pdfantimicrobial resistanceantimicrobial surveillancedrug information centres |
| spellingShingle | Soanker Radhika MVS Subbalaxmi Butul Maleha Pingali Usharani Impact of Drug Information Services on Promotion of Rational Use of Antimicrobial Agents: A Descriptive Retrospective Study Journal of Clinical and Diagnostic Research antimicrobial resistance antimicrobial surveillance drug information centres |
| title | Impact of Drug Information Services on Promotion of Rational Use of Antimicrobial Agents: A Descriptive Retrospective Study |
| title_full | Impact of Drug Information Services on Promotion of Rational Use of Antimicrobial Agents: A Descriptive Retrospective Study |
| title_fullStr | Impact of Drug Information Services on Promotion of Rational Use of Antimicrobial Agents: A Descriptive Retrospective Study |
| title_full_unstemmed | Impact of Drug Information Services on Promotion of Rational Use of Antimicrobial Agents: A Descriptive Retrospective Study |
| title_short | Impact of Drug Information Services on Promotion of Rational Use of Antimicrobial Agents: A Descriptive Retrospective Study |
| title_sort | impact of drug information services on promotion of rational use of antimicrobial agents a descriptive retrospective study |
| topic | antimicrobial resistance antimicrobial surveillance drug information centres |
| url | https://www.jcdr.net/articles/PDF/14916/49002_CE[Ra1]_F[SK]_PF1(AKA_SL)_PFA(AKA_KM)_PN(KM).pdf |
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