Green synthesis of ZnO nanoparticles using Ficus palmata: Antioxidant, antibacterial and antidiabetic studies
Nanotechnology have paved the way for novel and more efficient methods for the treatment of various diseases like cancer and type 2 diabetes mellitus. In this study, the leaf extract of Ficus palmata was used as stabilizing and reducing agent for the synthesis of zinc oxide nanoparticles using zinc...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Results in Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715622002284 |
| _version_ | 1811295067443298304 |
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| author | Avinash Sharma Rupak Nagraik Somesh Sharma Gaurav Sharma Sadanand Pandey Shavkatjon Azizov Pankaj Kumar Chauhan Deepak Kumar |
| author_facet | Avinash Sharma Rupak Nagraik Somesh Sharma Gaurav Sharma Sadanand Pandey Shavkatjon Azizov Pankaj Kumar Chauhan Deepak Kumar |
| author_sort | Avinash Sharma |
| collection | DOAJ |
| description | Nanotechnology have paved the way for novel and more efficient methods for the treatment of various diseases like cancer and type 2 diabetes mellitus. In this study, the leaf extract of Ficus palmata was used as stabilizing and reducing agent for the synthesis of zinc oxide nanoparticles using zinc acetate solution. The prepared FP ZnO NPs were identified and characterized using UV–vis spectroscopy, Dynamic light scattering (DLS), Fourier transformed infrared spectroscopy (FTIR), Field emission scanning electron microscopy (FESEM), and Energy-dispersive spectrum (EDS). The green synthesized ZnO NPs by Ficus palmata (FP ZnONPs) were evaluated for their antioxidant, antimicrobial activity, and cytotoxicity against the human FR2 cell line. They exhibited antioxidant activity and good antibacterial activity against Staphylococcus aureus, Bacillus subtilus, Escherichia coli, Salmonella typhi, Klebsiella pneumoniae. Further, green synthesized FP ZnO NPs were also evaluated for in vitro and in vivo antidiabetic activity. The results showed that nanoparticles exhibit better antidiabetic activity as compared to the plant extracts. The percentage of inhibition for amylase and glucosidase was higher in FP ZnONPs. It was found to be 70.07 ± 0.07 µg/ml in amylase and 68.49 ± 0.43 µg/ml in the glucosidase inhibition assay. It also showed a significant (p < 0.05) decrease in blood glucose level as compared to a diabetic control group from 21st to till 42nd day. It improves the lipid profile by decreasing the levels of triglycerides, total cholesterol, low-density lipoprotein (LDL) cholesterol and increasing the high-density lipoprotein (HDL) cholesterol level. Overall, the results highlight the effectiveness and potential applications of FP ZnO NPs for therapeutic purposes. |
| first_indexed | 2024-04-13T05:26:50Z |
| format | Article |
| id | doaj.art-a950a302224c449382dee8bb08d7d096 |
| institution | Directory Open Access Journal |
| issn | 2211-7156 |
| language | English |
| last_indexed | 2024-04-13T05:26:50Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj.art-a950a302224c449382dee8bb08d7d0962022-12-22T03:00:34ZengElsevierResults in Chemistry2211-71562022-01-014100509Green synthesis of ZnO nanoparticles using Ficus palmata: Antioxidant, antibacterial and antidiabetic studiesAvinash Sharma0Rupak Nagraik1Somesh Sharma2Gaurav Sharma3Sadanand Pandey4Shavkatjon Azizov5Pankaj Kumar Chauhan6Deepak Kumar7Faculty of Applied Sciences and Biotechnology, Shoolini University, Solan 173 229, IndiaFaculty of Applied Sciences and Biotechnology, Shoolini University, Solan 173 229, IndiaFaculty of Applied Sciences and Biotechnology, Shoolini University, Solan 173 229, IndiaDepartment of Pharmacology, School of Pharmaceutical Sciences, Shoolini University, Solan 173229, IndiaDepartment of Chemistry, College of Natural Sciences, Yeungnam University, Gyeongsan, Gyeongbuk 38541, South KoreaLaboratory of Biological Active Macromolecular Systems, Institute of Bioorganic Chemistry, Academy of Sciences Uzbekistan and Department of Pharmaceutical Chemistry, Tashkent Pharmaceutical Institute, Tashkent 100015, UzbekistanFaculty of Applied Sciences and Biotechnology, Shoolini University, Solan 173 229, India; Corresponding authors.Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Shoolini University, Solan 173 229, India; Corresponding authors.Nanotechnology have paved the way for novel and more efficient methods for the treatment of various diseases like cancer and type 2 diabetes mellitus. In this study, the leaf extract of Ficus palmata was used as stabilizing and reducing agent for the synthesis of zinc oxide nanoparticles using zinc acetate solution. The prepared FP ZnO NPs were identified and characterized using UV–vis spectroscopy, Dynamic light scattering (DLS), Fourier transformed infrared spectroscopy (FTIR), Field emission scanning electron microscopy (FESEM), and Energy-dispersive spectrum (EDS). The green synthesized ZnO NPs by Ficus palmata (FP ZnONPs) were evaluated for their antioxidant, antimicrobial activity, and cytotoxicity against the human FR2 cell line. They exhibited antioxidant activity and good antibacterial activity against Staphylococcus aureus, Bacillus subtilus, Escherichia coli, Salmonella typhi, Klebsiella pneumoniae. Further, green synthesized FP ZnO NPs were also evaluated for in vitro and in vivo antidiabetic activity. The results showed that nanoparticles exhibit better antidiabetic activity as compared to the plant extracts. The percentage of inhibition for amylase and glucosidase was higher in FP ZnONPs. It was found to be 70.07 ± 0.07 µg/ml in amylase and 68.49 ± 0.43 µg/ml in the glucosidase inhibition assay. It also showed a significant (p < 0.05) decrease in blood glucose level as compared to a diabetic control group from 21st to till 42nd day. It improves the lipid profile by decreasing the levels of triglycerides, total cholesterol, low-density lipoprotein (LDL) cholesterol and increasing the high-density lipoprotein (HDL) cholesterol level. Overall, the results highlight the effectiveness and potential applications of FP ZnO NPs for therapeutic purposes.http://www.sciencedirect.com/science/article/pii/S2211715622002284Green synthesisFicus palmataZinc oxide NanoparticlesAntibacterialAntidiabeticCytotoxicity |
| spellingShingle | Avinash Sharma Rupak Nagraik Somesh Sharma Gaurav Sharma Sadanand Pandey Shavkatjon Azizov Pankaj Kumar Chauhan Deepak Kumar Green synthesis of ZnO nanoparticles using Ficus palmata: Antioxidant, antibacterial and antidiabetic studies Results in Chemistry Green synthesis Ficus palmata Zinc oxide Nanoparticles Antibacterial Antidiabetic Cytotoxicity |
| title | Green synthesis of ZnO nanoparticles using Ficus palmata: Antioxidant, antibacterial and antidiabetic studies |
| title_full | Green synthesis of ZnO nanoparticles using Ficus palmata: Antioxidant, antibacterial and antidiabetic studies |
| title_fullStr | Green synthesis of ZnO nanoparticles using Ficus palmata: Antioxidant, antibacterial and antidiabetic studies |
| title_full_unstemmed | Green synthesis of ZnO nanoparticles using Ficus palmata: Antioxidant, antibacterial and antidiabetic studies |
| title_short | Green synthesis of ZnO nanoparticles using Ficus palmata: Antioxidant, antibacterial and antidiabetic studies |
| title_sort | green synthesis of zno nanoparticles using ficus palmata antioxidant antibacterial and antidiabetic studies |
| topic | Green synthesis Ficus palmata Zinc oxide Nanoparticles Antibacterial Antidiabetic Cytotoxicity |
| url | http://www.sciencedirect.com/science/article/pii/S2211715622002284 |
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