Perspective for Precision Medicine for Tuberculosis
Tuberculosis is a bacterial infectious disease that is mainly transmitted from human to human via infectious aerosols. Currently, tuberculosis is the leading cause of death by an infectious disease world-wide. In the past decade, the number of patients affected by tuberculosis has increased by ~20 p...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.566608/full |
| _version_ | 1818199006667341824 |
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| author | Christoph Lange Christoph Lange Christoph Lange Christoph Lange Christoph Lange Rob Aarnoutse Dumitru Chesov Dumitru Chesov Dumitru Chesov Dumitru Chesov Reinout van Crevel Stephen H. Gillespie Hans-Peter Grobbel Hans-Peter Grobbel Hans-Peter Grobbel Barbara Kalsdorf Barbara Kalsdorf Barbara Kalsdorf Barbara Kalsdorf Irina Kontsevaya Irina Kontsevaya Irina Kontsevaya Arjan van Laarhoven Tomoki Nishiguchi Anna Mandalakas Matthias Merker Matthias Merker Matthias Merker Stefan Niemann Stefan Niemann Stefan Niemann Niklas Köhler Niklas Köhler Niklas Köhler Jan Heyckendorf Jan Heyckendorf Jan Heyckendorf Maja Reimann Maja Reimann Maja Reimann Morten Ruhwald Patricia Sanchez-Carballo Patricia Sanchez-Carballo Patricia Sanchez-Carballo Dominik Schwudke Dominik Schwudke Dominik Schwudke Franziska Waldow Franziska Waldow Andrew R. DiNardo |
| author_facet | Christoph Lange Christoph Lange Christoph Lange Christoph Lange Christoph Lange Rob Aarnoutse Dumitru Chesov Dumitru Chesov Dumitru Chesov Dumitru Chesov Reinout van Crevel Stephen H. Gillespie Hans-Peter Grobbel Hans-Peter Grobbel Hans-Peter Grobbel Barbara Kalsdorf Barbara Kalsdorf Barbara Kalsdorf Barbara Kalsdorf Irina Kontsevaya Irina Kontsevaya Irina Kontsevaya Arjan van Laarhoven Tomoki Nishiguchi Anna Mandalakas Matthias Merker Matthias Merker Matthias Merker Stefan Niemann Stefan Niemann Stefan Niemann Niklas Köhler Niklas Köhler Niklas Köhler Jan Heyckendorf Jan Heyckendorf Jan Heyckendorf Maja Reimann Maja Reimann Maja Reimann Morten Ruhwald Patricia Sanchez-Carballo Patricia Sanchez-Carballo Patricia Sanchez-Carballo Dominik Schwudke Dominik Schwudke Dominik Schwudke Franziska Waldow Franziska Waldow Andrew R. DiNardo |
| author_sort | Christoph Lange |
| collection | DOAJ |
| description | Tuberculosis is a bacterial infectious disease that is mainly transmitted from human to human via infectious aerosols. Currently, tuberculosis is the leading cause of death by an infectious disease world-wide. In the past decade, the number of patients affected by tuberculosis has increased by ~20 percent and the emergence of drug-resistant strains of Mycobacterium tuberculosis challenges the goal of elimination of tuberculosis in the near future. For the last 50 years, management of patients with tuberculosis has followed a standardized management approach. This standardization neglects the variation in human susceptibility to infection, immune response, the pharmacokinetics of drugs, and the individual duration of treatment needed to achieve relapse-free cure. Here we propose a package of precision medicine-guided therapies that has the prospect to drive clinical management decisions, based on both host immunity and M. tuberculosis strains genetics. Recently, important scientific discoveries and technological advances have been achieved that provide a perspective for individualized rather than standardized management of patients with tuberculosis. For the individual selection of best medicines and host-directed therapies, personalized drug dosing, and treatment durations, physicians treating patients with tuberculosis will be able to rely on these advances in systems biology and to apply them at the bedside. |
| first_indexed | 2024-12-12T02:14:54Z |
| format | Article |
| id | doaj.art-a9519587606f40858abc88bdda14edc9 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-12T02:14:54Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-a9519587606f40858abc88bdda14edc92022-12-22T00:41:49ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-10-011110.3389/fimmu.2020.566608566608Perspective for Precision Medicine for TuberculosisChristoph Lange0Christoph Lange1Christoph Lange2Christoph Lange3Christoph Lange4Rob Aarnoutse5Dumitru Chesov6Dumitru Chesov7Dumitru Chesov8Dumitru Chesov9Reinout van Crevel10Stephen H. Gillespie11Hans-Peter Grobbel12Hans-Peter Grobbel13Hans-Peter Grobbel14Barbara Kalsdorf15Barbara Kalsdorf16Barbara Kalsdorf17Barbara Kalsdorf18Irina Kontsevaya19Irina Kontsevaya20Irina Kontsevaya21Arjan van Laarhoven22Tomoki Nishiguchi23Anna Mandalakas24Matthias Merker25Matthias Merker26Matthias Merker27Stefan Niemann28Stefan Niemann29Stefan Niemann30Niklas Köhler31Niklas Köhler32Niklas Köhler33Jan Heyckendorf34Jan Heyckendorf35Jan Heyckendorf36Maja Reimann37Maja Reimann38Maja Reimann39Morten Ruhwald40Patricia Sanchez-Carballo41Patricia Sanchez-Carballo42Patricia Sanchez-Carballo43Dominik Schwudke44Dominik Schwudke45Dominik Schwudke46Franziska Waldow47Franziska Waldow48Andrew R. DiNardo49Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, GermanyGerman Center for Infection Research (DZIF) Partner Site Borstel-Hamburg-Lübeck-Riems, Borstel, GermanyRespiratory Medicine and International Health, University of Lübeck, Lübeck, GermanyCluster of Excellence Precision Medicine in Chronic Inflammation, Kiel, GermanyDepartment of Medicine, Karolinska Institute, Stockholm, SwedenDepartment of Internal Medicine, Radboud Center of Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, NetherlandsDivision of Clinical Infectious Diseases, Research Center Borstel, Borstel, GermanyGerman Center for Infection Research (DZIF) Partner Site Borstel-Hamburg-Lübeck-Riems, Borstel, GermanyRespiratory Medicine and International Health, University of Lübeck, Lübeck, GermanyDepartment of Pulmonology and Allergology, Nicolae Testemitanu University of Medicine and Pharmacy, Chisinau, MoldovaDepartment of Internal Medicine, Radboud Center of Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, NetherlandsSchool of Medicine, University of St Andrews, St Andrews, United KingdomDivision of Clinical Infectious Diseases, Research Center Borstel, Borstel, GermanyGerman Center for Infection Research (DZIF) Partner Site Borstel-Hamburg-Lübeck-Riems, Borstel, GermanyRespiratory Medicine and International Health, University of Lübeck, Lübeck, GermanyDivision of Clinical Infectious Diseases, Research Center Borstel, Borstel, GermanyGerman Center for Infection Research (DZIF) Partner Site Borstel-Hamburg-Lübeck-Riems, Borstel, GermanyRespiratory Medicine and International Health, University of Lübeck, Lübeck, GermanyCluster of Excellence Precision Medicine in Chronic Inflammation, Kiel, GermanyDivision of Clinical Infectious Diseases, Research Center Borstel, Borstel, GermanyGerman Center for Infection Research (DZIF) Partner Site Borstel-Hamburg-Lübeck-Riems, Borstel, GermanyRespiratory Medicine and International Health, University of Lübeck, Lübeck, GermanyDepartment of Internal Medicine, Radboud Center of Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, NetherlandsThe Global Tuberculosis Program, Texas Children's Hospital, Immigrant and Global Health, Department of Pediatrics, Baylor College of Medicine, Houston, TX, United StatesThe Global Tuberculosis Program, Texas Children's Hospital, Immigrant and Global Health, Department of Pediatrics, Baylor College of Medicine, Houston, TX, United StatesGerman Center for Infection Research (DZIF) Partner Site Borstel-Hamburg-Lübeck-Riems, Borstel, GermanyCluster of Excellence Precision Medicine in Chronic Inflammation, Kiel, Germany0Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, GermanyGerman Center for Infection Research (DZIF) Partner Site Borstel-Hamburg-Lübeck-Riems, Borstel, GermanyCluster of Excellence Precision Medicine in Chronic Inflammation, Kiel, Germany0Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, GermanyDivision of Clinical Infectious Diseases, Research Center Borstel, Borstel, GermanyGerman Center for Infection Research (DZIF) Partner Site Borstel-Hamburg-Lübeck-Riems, Borstel, GermanyRespiratory Medicine and International Health, University of Lübeck, Lübeck, GermanyDivision of Clinical Infectious Diseases, Research Center Borstel, Borstel, GermanyGerman Center for Infection Research (DZIF) Partner Site Borstel-Hamburg-Lübeck-Riems, Borstel, GermanyRespiratory Medicine and International Health, University of Lübeck, Lübeck, GermanyDivision of Clinical Infectious Diseases, Research Center Borstel, Borstel, GermanyGerman Center for Infection Research (DZIF) Partner Site Borstel-Hamburg-Lübeck-Riems, Borstel, GermanyRespiratory Medicine and International Health, University of Lübeck, Lübeck, Germany1Foundation of Innovative New Diagnostics (FIND), Geneva, SwitzerlandDivision of Clinical Infectious Diseases, Research Center Borstel, Borstel, GermanyGerman Center for Infection Research (DZIF) Partner Site Borstel-Hamburg-Lübeck-Riems, Borstel, GermanyRespiratory Medicine and International Health, University of Lübeck, Lübeck, GermanyGerman Center for Infection Research (DZIF) Partner Site Borstel-Hamburg-Lübeck-Riems, Borstel, Germany2Bioanalytical Chemistry, Priority Area Infection, Research Center Borstel, Leibniz Lung Center, Borstel, Germany3Airway Research Center North, German Center for Lung Research (DZL), Borstel, GermanyGerman Center for Infection Research (DZIF) Partner Site Borstel-Hamburg-Lübeck-Riems, Borstel, Germany2Bioanalytical Chemistry, Priority Area Infection, Research Center Borstel, Leibniz Lung Center, Borstel, GermanyThe Global Tuberculosis Program, Texas Children's Hospital, Immigrant and Global Health, Department of Pediatrics, Baylor College of Medicine, Houston, TX, United StatesTuberculosis is a bacterial infectious disease that is mainly transmitted from human to human via infectious aerosols. Currently, tuberculosis is the leading cause of death by an infectious disease world-wide. In the past decade, the number of patients affected by tuberculosis has increased by ~20 percent and the emergence of drug-resistant strains of Mycobacterium tuberculosis challenges the goal of elimination of tuberculosis in the near future. For the last 50 years, management of patients with tuberculosis has followed a standardized management approach. This standardization neglects the variation in human susceptibility to infection, immune response, the pharmacokinetics of drugs, and the individual duration of treatment needed to achieve relapse-free cure. Here we propose a package of precision medicine-guided therapies that has the prospect to drive clinical management decisions, based on both host immunity and M. tuberculosis strains genetics. Recently, important scientific discoveries and technological advances have been achieved that provide a perspective for individualized rather than standardized management of patients with tuberculosis. For the individual selection of best medicines and host-directed therapies, personalized drug dosing, and treatment durations, physicians treating patients with tuberculosis will be able to rely on these advances in systems biology and to apply them at the bedside.https://www.frontiersin.org/article/10.3389/fimmu.2020.566608/fullprecision medicinetuberculosistailor-made regimenmycobacterial genotypesendotypes |
| spellingShingle | Christoph Lange Christoph Lange Christoph Lange Christoph Lange Christoph Lange Rob Aarnoutse Dumitru Chesov Dumitru Chesov Dumitru Chesov Dumitru Chesov Reinout van Crevel Stephen H. Gillespie Hans-Peter Grobbel Hans-Peter Grobbel Hans-Peter Grobbel Barbara Kalsdorf Barbara Kalsdorf Barbara Kalsdorf Barbara Kalsdorf Irina Kontsevaya Irina Kontsevaya Irina Kontsevaya Arjan van Laarhoven Tomoki Nishiguchi Anna Mandalakas Matthias Merker Matthias Merker Matthias Merker Stefan Niemann Stefan Niemann Stefan Niemann Niklas Köhler Niklas Köhler Niklas Köhler Jan Heyckendorf Jan Heyckendorf Jan Heyckendorf Maja Reimann Maja Reimann Maja Reimann Morten Ruhwald Patricia Sanchez-Carballo Patricia Sanchez-Carballo Patricia Sanchez-Carballo Dominik Schwudke Dominik Schwudke Dominik Schwudke Franziska Waldow Franziska Waldow Andrew R. DiNardo Perspective for Precision Medicine for Tuberculosis Frontiers in Immunology precision medicine tuberculosis tailor-made regimen mycobacterial genotypes endotypes |
| title | Perspective for Precision Medicine for Tuberculosis |
| title_full | Perspective for Precision Medicine for Tuberculosis |
| title_fullStr | Perspective for Precision Medicine for Tuberculosis |
| title_full_unstemmed | Perspective for Precision Medicine for Tuberculosis |
| title_short | Perspective for Precision Medicine for Tuberculosis |
| title_sort | perspective for precision medicine for tuberculosis |
| topic | precision medicine tuberculosis tailor-made regimen mycobacterial genotypes endotypes |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.566608/full |
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