Prognostic value of the number of biopsied sentinel lymph nodes for Chinese patients with melanoma: A single‐center retrospective study
Abstract Background Sentinel lymph node biopsy (SLNB) helps to determine accurate pathological stages and facilitates strategies for regional disease control in melanoma. However, whether the number of biopsied sentinel lymph nodes (SLNs) influences the patients' survival is rarely investigated...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-02-01
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| Series: | Cancer Reports |
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| Online Access: | https://doi.org/10.1002/cnr2.1958 |
| _version_ | 1797292565662269440 |
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| author | Tu Hu Yu Xu Wangjun Yan Chunmeng Wang Wei Sun Yunyi Kong Yong Chen |
| author_facet | Tu Hu Yu Xu Wangjun Yan Chunmeng Wang Wei Sun Yunyi Kong Yong Chen |
| author_sort | Tu Hu |
| collection | DOAJ |
| description | Abstract Background Sentinel lymph node biopsy (SLNB) helps to determine accurate pathological stages and facilitates strategies for regional disease control in melanoma. However, whether the number of biopsied sentinel lymph nodes (SLNs) influences the patients' survival is rarely investigated. Methods Acral or cutaneous melanoma patients with no history of nodal disease who received SLNB in Fudan University Shanghai Cancer Center (FUSCC) from January 1, 2017, to December 31, 2021 were retrospectively enrolled. Clinicopathological variables including Breslow index, ulceration, number of positive SLNs, SLN/non‐SLN status were analyzed. The pathologic nodal (pN) stage and pathological stage were defined. Results A total of 381 eligible patients were enrolled in this study, of whom 132 (34.7%) patients were diagnosed with SLN‐positive. The median number of biopsied SLNs was 2 (range: 1 to 20). Different numbers of biopsied SLNs did not influence the release‐free survival (RFS) of the general patients. However, patients with >2 SLNs had a longer RFS than those with 1–2 SLNs in T4, N1a group and those who rejected complete lymph node dissection (CLND). Conclusions In patients with T4 melanomas, N1a melanomas and those that did not undergo a CLND, the prognosis of those with three or more SLNs retrieved seemed to be improved. |
| first_indexed | 2024-03-07T19:58:18Z |
| format | Article |
| id | doaj.art-a953289ee4d14133b60c672260619fe4 |
| institution | Directory Open Access Journal |
| issn | 2573-8348 |
| language | English |
| last_indexed | 2024-03-07T19:58:18Z |
| publishDate | 2024-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Reports |
| spelling | doaj.art-a953289ee4d14133b60c672260619fe42024-02-28T13:54:58ZengWileyCancer Reports2573-83482024-02-0172n/an/a10.1002/cnr2.1958Prognostic value of the number of biopsied sentinel lymph nodes for Chinese patients with melanoma: A single‐center retrospective studyTu Hu0Yu Xu1Wangjun Yan2Chunmeng Wang3Wei Sun4Yunyi Kong5Yong Chen6Department of Musculoskeletal Surgery Fudan University Shanghai Cancer Center Shanghai ChinaDepartment of Musculoskeletal Surgery Fudan University Shanghai Cancer Center Shanghai ChinaDepartment of Musculoskeletal Surgery Fudan University Shanghai Cancer Center Shanghai ChinaDepartment of Musculoskeletal Surgery Fudan University Shanghai Cancer Center Shanghai ChinaDepartment of Musculoskeletal Surgery Fudan University Shanghai Cancer Center Shanghai ChinaDepartment of Pathology Fudan University Shanghai Cancer Center, Fudan University Shanghai ChinaDepartment of Musculoskeletal Surgery Fudan University Shanghai Cancer Center Shanghai ChinaAbstract Background Sentinel lymph node biopsy (SLNB) helps to determine accurate pathological stages and facilitates strategies for regional disease control in melanoma. However, whether the number of biopsied sentinel lymph nodes (SLNs) influences the patients' survival is rarely investigated. Methods Acral or cutaneous melanoma patients with no history of nodal disease who received SLNB in Fudan University Shanghai Cancer Center (FUSCC) from January 1, 2017, to December 31, 2021 were retrospectively enrolled. Clinicopathological variables including Breslow index, ulceration, number of positive SLNs, SLN/non‐SLN status were analyzed. The pathologic nodal (pN) stage and pathological stage were defined. Results A total of 381 eligible patients were enrolled in this study, of whom 132 (34.7%) patients were diagnosed with SLN‐positive. The median number of biopsied SLNs was 2 (range: 1 to 20). Different numbers of biopsied SLNs did not influence the release‐free survival (RFS) of the general patients. However, patients with >2 SLNs had a longer RFS than those with 1–2 SLNs in T4, N1a group and those who rejected complete lymph node dissection (CLND). Conclusions In patients with T4 melanomas, N1a melanomas and those that did not undergo a CLND, the prognosis of those with three or more SLNs retrieved seemed to be improved.https://doi.org/10.1002/cnr2.1958lymph node metastasismelanomaprognosissentinel lymph node biopsy |
| spellingShingle | Tu Hu Yu Xu Wangjun Yan Chunmeng Wang Wei Sun Yunyi Kong Yong Chen Prognostic value of the number of biopsied sentinel lymph nodes for Chinese patients with melanoma: A single‐center retrospective study Cancer Reports lymph node metastasis melanoma prognosis sentinel lymph node biopsy |
| title | Prognostic value of the number of biopsied sentinel lymph nodes for Chinese patients with melanoma: A single‐center retrospective study |
| title_full | Prognostic value of the number of biopsied sentinel lymph nodes for Chinese patients with melanoma: A single‐center retrospective study |
| title_fullStr | Prognostic value of the number of biopsied sentinel lymph nodes for Chinese patients with melanoma: A single‐center retrospective study |
| title_full_unstemmed | Prognostic value of the number of biopsied sentinel lymph nodes for Chinese patients with melanoma: A single‐center retrospective study |
| title_short | Prognostic value of the number of biopsied sentinel lymph nodes for Chinese patients with melanoma: A single‐center retrospective study |
| title_sort | prognostic value of the number of biopsied sentinel lymph nodes for chinese patients with melanoma a single center retrospective study |
| topic | lymph node metastasis melanoma prognosis sentinel lymph node biopsy |
| url | https://doi.org/10.1002/cnr2.1958 |
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