Clinical application of 18F-FCH PET/CT in the diagnosis and treatment of hyperparathyroidism
ObjectiveWe evaluated the difference in parathyroid visualization on 18F-FCH PET/CT images obtained at 5 and 60 min, and quantitatively analyzed the mode of FCH uptake at different time points, to determine the best imaging time for FCH PET/CT.MethodsThis retrospective study included 73 patients wit...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1100056/full |
| _version_ | 1797849193024323584 |
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| author | Shuang Liu Mengdan Li Hua Pang Rui Zuo Lingquan Kong Zhengjie Wang Wenbo Li Zhu Xia Dong Wang Lu Xu |
| author_facet | Shuang Liu Mengdan Li Hua Pang Rui Zuo Lingquan Kong Zhengjie Wang Wenbo Li Zhu Xia Dong Wang Lu Xu |
| author_sort | Shuang Liu |
| collection | DOAJ |
| description | ObjectiveWe evaluated the difference in parathyroid visualization on 18F-FCH PET/CT images obtained at 5 and 60 min, and quantitatively analyzed the mode of FCH uptake at different time points, to determine the best imaging time for FCH PET/CT.MethodsThis retrospective study included 73 patients with hyperparathyroidism (HPT) who underwent 18F-FCH PET/CT imaging between December 2017 and December 2021. The diagnostic efficiency of 5- and 60-min dual time point imaging for the diagnosis of hyperparathyroidism and parathyroid adenoma and hyperplasia, were compared using visual and quantitative analyses.ResultsDual-time 18F-FCH PET/CT imaging visual analysis had diagnostic value for HPT. The receiver operating characteristic curve of PET/CT quantitative parameters for the diagnosis of HPT and lesions showed that the parathyroid/thyroid SUVmax ratio for 60-min imaging had a higher sensitivity and specificity (based on patient, sensitivity: 90.90% and specificity: 85.71%; based on focus, sensitivity: 83.06% and specificity: 85.71%) compared to that for 5-min imaging. PET/CT quantitative parameters can distinguish parathyroid adenoma and hyperplasia. The 60-min parathyroid SUVmax value had the highest diagnostic value (cutoff: 3.945; area under the curve: 0.783).ConclusionThe quantitative parameters of 60min 18F-FCH PET/CT have more advantages in aiding in the pathologica diagnosis and clinical treatment of HPT. |
| first_indexed | 2024-04-09T18:40:57Z |
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| id | doaj.art-a953dd528c094fae871e7c6d75ba5030 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-09T18:40:57Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-a953dd528c094fae871e7c6d75ba50302023-04-11T05:37:27ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-04-011410.3389/fendo.2023.11000561100056Clinical application of 18F-FCH PET/CT in the diagnosis and treatment of hyperparathyroidismShuang Liu0Mengdan Li1Hua Pang2Rui Zuo3Lingquan Kong4Zhengjie Wang5Wenbo Li6Zhu Xia7Dong Wang8Lu Xu9Department of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Breast Thyroid Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Ultrasound Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaObjectiveWe evaluated the difference in parathyroid visualization on 18F-FCH PET/CT images obtained at 5 and 60 min, and quantitatively analyzed the mode of FCH uptake at different time points, to determine the best imaging time for FCH PET/CT.MethodsThis retrospective study included 73 patients with hyperparathyroidism (HPT) who underwent 18F-FCH PET/CT imaging between December 2017 and December 2021. The diagnostic efficiency of 5- and 60-min dual time point imaging for the diagnosis of hyperparathyroidism and parathyroid adenoma and hyperplasia, were compared using visual and quantitative analyses.ResultsDual-time 18F-FCH PET/CT imaging visual analysis had diagnostic value for HPT. The receiver operating characteristic curve of PET/CT quantitative parameters for the diagnosis of HPT and lesions showed that the parathyroid/thyroid SUVmax ratio for 60-min imaging had a higher sensitivity and specificity (based on patient, sensitivity: 90.90% and specificity: 85.71%; based on focus, sensitivity: 83.06% and specificity: 85.71%) compared to that for 5-min imaging. PET/CT quantitative parameters can distinguish parathyroid adenoma and hyperplasia. The 60-min parathyroid SUVmax value had the highest diagnostic value (cutoff: 3.945; area under the curve: 0.783).ConclusionThe quantitative parameters of 60min 18F-FCH PET/CT have more advantages in aiding in the pathologica diagnosis and clinical treatment of HPT.https://www.frontiersin.org/articles/10.3389/fendo.2023.1100056/fullhyperparathyroidism18F-FCH PET/CTquantitative studydiagnosisimaging time selection |
| spellingShingle | Shuang Liu Mengdan Li Hua Pang Rui Zuo Lingquan Kong Zhengjie Wang Wenbo Li Zhu Xia Dong Wang Lu Xu Clinical application of 18F-FCH PET/CT in the diagnosis and treatment of hyperparathyroidism Frontiers in Endocrinology hyperparathyroidism 18F-FCH PET/CT quantitative study diagnosis imaging time selection |
| title | Clinical application of 18F-FCH PET/CT in the diagnosis and treatment of hyperparathyroidism |
| title_full | Clinical application of 18F-FCH PET/CT in the diagnosis and treatment of hyperparathyroidism |
| title_fullStr | Clinical application of 18F-FCH PET/CT in the diagnosis and treatment of hyperparathyroidism |
| title_full_unstemmed | Clinical application of 18F-FCH PET/CT in the diagnosis and treatment of hyperparathyroidism |
| title_short | Clinical application of 18F-FCH PET/CT in the diagnosis and treatment of hyperparathyroidism |
| title_sort | clinical application of 18f fch pet ct in the diagnosis and treatment of hyperparathyroidism |
| topic | hyperparathyroidism 18F-FCH PET/CT quantitative study diagnosis imaging time selection |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1100056/full |
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