Post-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq
MicroRNAs have been best characterized for their functions in the cytoplasm; however, there is growing evidence of a nuclear localized role. Here, the authors identify Sfpq as an Ago2-interacting protein that modulates miRNA activity in both the nucleus and cytoplasm.
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-10-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-01126-x |
| _version_ | 1818996297976250368 |
|---|---|
| author | Silvia Bottini Nedra Hamouda-Tekaya Raphael Mategot Laure-Emmanuelle Zaragosi Stephane Audebert Sabrina Pisano Valerie Grandjean Claire Mauduit Mohamed Benahmed Pascal Barbry Emanuela Repetto Michele Trabucchi |
| author_facet | Silvia Bottini Nedra Hamouda-Tekaya Raphael Mategot Laure-Emmanuelle Zaragosi Stephane Audebert Sabrina Pisano Valerie Grandjean Claire Mauduit Mohamed Benahmed Pascal Barbry Emanuela Repetto Michele Trabucchi |
| author_sort | Silvia Bottini |
| collection | DOAJ |
| description | MicroRNAs have been best characterized for their functions in the cytoplasm; however, there is growing evidence of a nuclear localized role. Here, the authors identify Sfpq as an Ago2-interacting protein that modulates miRNA activity in both the nucleus and cytoplasm. |
| first_indexed | 2024-12-20T21:27:30Z |
| format | Article |
| id | doaj.art-a9569527816747cead945fe23c5ab98f |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T21:27:30Z |
| publishDate | 2017-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a9569527816747cead945fe23c5ab98f2022-12-21T19:26:08ZengNature PortfolioNature Communications2041-17232017-10-018111610.1038/s41467-017-01126-xPost-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic SfpqSilvia Bottini0Nedra Hamouda-Tekaya1Raphael Mategot2Laure-Emmanuelle Zaragosi3Stephane Audebert4Sabrina Pisano5Valerie Grandjean6Claire Mauduit7Mohamed Benahmed8Pascal Barbry9Emanuela Repetto10Michele Trabucchi11INSERM U1065, C3M, Team Control of Gene Expression (10)INSERM U1065, C3M, Team Control of Gene Expression (10)INSERM U1065, C3M, Team Control of Gene Expression (10)Université Côte d’Azur, CNRS, IPMCCRCM, Marseille Protéomique, Institut Paoli-Calmettes, Aix Marseille University, INSERM, CNRSUniversité Côte d’Azur, CNRS, INSERM, IRCANINSERM U1065, C3M, Team Control of Gene Expression (10)INSERM U1065, C3M, Team Control of Gene Expression (10)Université Côte d’Azur, INSERM, C3MUniversité Côte d’Azur, CNRS, IPMCINSERM U1065, C3M, Team Control of Gene Expression (10)INSERM U1065, C3M, Team Control of Gene Expression (10)MicroRNAs have been best characterized for their functions in the cytoplasm; however, there is growing evidence of a nuclear localized role. Here, the authors identify Sfpq as an Ago2-interacting protein that modulates miRNA activity in both the nucleus and cytoplasm.https://doi.org/10.1038/s41467-017-01126-x |
| spellingShingle | Silvia Bottini Nedra Hamouda-Tekaya Raphael Mategot Laure-Emmanuelle Zaragosi Stephane Audebert Sabrina Pisano Valerie Grandjean Claire Mauduit Mohamed Benahmed Pascal Barbry Emanuela Repetto Michele Trabucchi Post-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq Nature Communications |
| title | Post-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq |
| title_full | Post-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq |
| title_fullStr | Post-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq |
| title_full_unstemmed | Post-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq |
| title_short | Post-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq |
| title_sort | post transcriptional gene silencing mediated by micrornas is controlled by nucleoplasmic sfpq |
| url | https://doi.org/10.1038/s41467-017-01126-x |
| work_keys_str_mv | AT silviabottini posttranscriptionalgenesilencingmediatedbymicrornasiscontrolledbynucleoplasmicsfpq AT nedrahamoudatekaya posttranscriptionalgenesilencingmediatedbymicrornasiscontrolledbynucleoplasmicsfpq AT raphaelmategot posttranscriptionalgenesilencingmediatedbymicrornasiscontrolledbynucleoplasmicsfpq AT laureemmanuellezaragosi posttranscriptionalgenesilencingmediatedbymicrornasiscontrolledbynucleoplasmicsfpq AT stephaneaudebert posttranscriptionalgenesilencingmediatedbymicrornasiscontrolledbynucleoplasmicsfpq AT sabrinapisano posttranscriptionalgenesilencingmediatedbymicrornasiscontrolledbynucleoplasmicsfpq AT valeriegrandjean posttranscriptionalgenesilencingmediatedbymicrornasiscontrolledbynucleoplasmicsfpq AT clairemauduit posttranscriptionalgenesilencingmediatedbymicrornasiscontrolledbynucleoplasmicsfpq AT mohamedbenahmed posttranscriptionalgenesilencingmediatedbymicrornasiscontrolledbynucleoplasmicsfpq AT pascalbarbry posttranscriptionalgenesilencingmediatedbymicrornasiscontrolledbynucleoplasmicsfpq AT emanuelarepetto posttranscriptionalgenesilencingmediatedbymicrornasiscontrolledbynucleoplasmicsfpq AT micheletrabucchi posttranscriptionalgenesilencingmediatedbymicrornasiscontrolledbynucleoplasmicsfpq |