Ménétrier’s Disease: Its Mimickers and Pathogenesis

Ménétrier’s disease is a rare protein-losing hypertrophic gastropathy. Histologically, it can be mistaken for other disorders showing hypertrophic gastropathy. The pathogenesis of Ménétrier’s disease is not fully understood; however, it appears that the epidermal growth factor receptor (EGFR) ligand...

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Main Authors: Won Jae Huh, Robert J. Coffey, Mary Kay Washington
Format: Article
Language:English
Published: Korean Society of Pathologists & the Korean Society for Cytopathology 2016-01-01
Series:Journal of Pathology and Translational Medicine
Subjects:
Online Access:http://www.jpatholtm.org/upload/pdf/jptm-2015-09-15.pdf
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author Won Jae Huh
Robert J. Coffey
Mary Kay Washington
author_facet Won Jae Huh
Robert J. Coffey
Mary Kay Washington
author_sort Won Jae Huh
collection DOAJ
description Ménétrier’s disease is a rare protein-losing hypertrophic gastropathy. Histologically, it can be mistaken for other disorders showing hypertrophic gastropathy. The pathogenesis of Ménétrier’s disease is not fully understood; however, it appears that the epidermal growth factor receptor (EGFR) ligand, transforming growth factor alpha, contributes to the pathogenesis of this disorder. In this review, we will discuss disease entities that can mimic Ménétrier’s disease and the role of EGFR signaling in Ménétrier’s disease.
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spelling doaj.art-a957b9f85eea4293bf3283172b3f0d072022-12-22T01:42:42ZengKorean Society of Pathologists & the Korean Society for CytopathologyJournal of Pathology and Translational Medicine2383-78372383-78452016-01-01501101610.4132/jptm.2015.09.1516580Ménétrier’s Disease: Its Mimickers and PathogenesisWon Jae Huh0Robert J. Coffey1Mary Kay Washington2 Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USAMénétrier’s disease is a rare protein-losing hypertrophic gastropathy. Histologically, it can be mistaken for other disorders showing hypertrophic gastropathy. The pathogenesis of Ménétrier’s disease is not fully understood; however, it appears that the epidermal growth factor receptor (EGFR) ligand, transforming growth factor alpha, contributes to the pathogenesis of this disorder. In this review, we will discuss disease entities that can mimic Ménétrier’s disease and the role of EGFR signaling in Ménétrier’s disease.http://www.jpatholtm.org/upload/pdf/jptm-2015-09-15.pdfMénétrier’s diseaseGastric polypTransforming growth factor alpha
spellingShingle Won Jae Huh
Robert J. Coffey
Mary Kay Washington
Ménétrier’s Disease: Its Mimickers and Pathogenesis
Journal of Pathology and Translational Medicine
Ménétrier’s disease
Gastric polyp
Transforming growth factor alpha
title Ménétrier’s Disease: Its Mimickers and Pathogenesis
title_full Ménétrier’s Disease: Its Mimickers and Pathogenesis
title_fullStr Ménétrier’s Disease: Its Mimickers and Pathogenesis
title_full_unstemmed Ménétrier’s Disease: Its Mimickers and Pathogenesis
title_short Ménétrier’s Disease: Its Mimickers and Pathogenesis
title_sort menetrier s disease its mimickers and pathogenesis
topic Ménétrier’s disease
Gastric polyp
Transforming growth factor alpha
url http://www.jpatholtm.org/upload/pdf/jptm-2015-09-15.pdf
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AT robertjcoffey menetriersdiseaseitsmimickersandpathogenesis
AT marykaywashington menetriersdiseaseitsmimickersandpathogenesis