A Systematic Review of Studies Published between 2016 and 2019 on the Effectiveness and Efficacy of Pneumococcal Vaccination on Pneumonia and Invasive Pneumococcal Disease in an Elderly Population
Adult vaccination is high on the agenda in many countries. Two different vaccines are available for the prevention of pneumococcal disease in adults: a 23-valent polysaccharide vaccine (PPV23), and a 13-valent conjugated vaccine (PCV13). The objective of this review is to update the evidence base fo...
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MDPI AG
2020-04-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/9/4/259 |
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| author | Jacob Dag Berild Brita Askeland Winje Didrik Frimann Vestrheim Hans-Christian Slotved Palle Valentiner-Branth Adam Roth Jann Storsäter |
| author_facet | Jacob Dag Berild Brita Askeland Winje Didrik Frimann Vestrheim Hans-Christian Slotved Palle Valentiner-Branth Adam Roth Jann Storsäter |
| author_sort | Jacob Dag Berild |
| collection | DOAJ |
| description | Adult vaccination is high on the agenda in many countries. Two different vaccines are available for the prevention of pneumococcal disease in adults: a 23-valent polysaccharide vaccine (PPV23), and a 13-valent conjugated vaccine (PCV13). The objective of this review is to update the evidence base for vaccine efficacy and effectiveness of PPV23 and PCV13 against invasive pneumococcal disease and pneumonia among an unselected elderly population. We systematically searched for clinical trials and observational studies published between January 1 2016 and April 17 2019 in Pubmed, Embase, Cinahl, Web of Science, Epistemonikos and Cochrane databases. Risk of bias was assessed using Cochrane Risk of Bias tool for and the Newcastle–Ottawa Scale. Results were stratified by vaccine type and outcome. We identified nine studies on PCV13 and six on PPV23. No new randomized clinical trials were identified. Due to different outcomes, it was not possible to do a meta-analysis. New high-quality observational studies indicate protective vaccine effectiveness for both vaccines against vaccine type pneumonia. Our estimates for the protective vaccine efficacy and effectiveness (VE) of PPV23 on pneumonia and pneumococcal pneumonia overlap with results from previously published reviews. Some of the results indicate that the effectiveness of the PPV23 is best in younger age groups, and that it decreases over time. |
| first_indexed | 2024-03-10T20:42:15Z |
| format | Article |
| id | doaj.art-a95a8342b96b4882b96e82cb5a4d9094 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T20:42:15Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-a95a8342b96b4882b96e82cb5a4d90942023-11-19T20:36:43ZengMDPI AGPathogens2076-08172020-04-019425910.3390/pathogens9040259A Systematic Review of Studies Published between 2016 and 2019 on the Effectiveness and Efficacy of Pneumococcal Vaccination on Pneumonia and Invasive Pneumococcal Disease in an Elderly PopulationJacob Dag Berild0Brita Askeland Winje1Didrik Frimann Vestrheim2Hans-Christian Slotved3Palle Valentiner-Branth4Adam Roth5Jann Storsäter6Department of Vaccine Preventable Diseases, Division of Infection Control and Environmental Health, Norwegian Institute of Public Health, 0213 Oslo, NorwayDepartment of Vaccine Preventable Diseases, Division of Infection Control and Environmental Health, Norwegian Institute of Public Health, 0213 Oslo, NorwayDepartment of Vaccine Preventable Diseases, Division of Infection Control and Environmental Health, Norwegian Institute of Public Health, 0213 Oslo, NorwayDepartment of Bacteria, Parasites and Fungi, Statens Serum Institute, 2300 Copenhagen, DenmarkInfectious Disease Epidemiology & Prevention, Statens Serum Institute, 2300 Copenhagen, DenmarkUnit for Vaccination Programmes, Public Health Agency of Sweden, 171 82 Solna, SwedenUnit for Vaccination Programmes, Public Health Agency of Sweden, 171 82 Solna, SwedenAdult vaccination is high on the agenda in many countries. Two different vaccines are available for the prevention of pneumococcal disease in adults: a 23-valent polysaccharide vaccine (PPV23), and a 13-valent conjugated vaccine (PCV13). The objective of this review is to update the evidence base for vaccine efficacy and effectiveness of PPV23 and PCV13 against invasive pneumococcal disease and pneumonia among an unselected elderly population. We systematically searched for clinical trials and observational studies published between January 1 2016 and April 17 2019 in Pubmed, Embase, Cinahl, Web of Science, Epistemonikos and Cochrane databases. Risk of bias was assessed using Cochrane Risk of Bias tool for and the Newcastle–Ottawa Scale. Results were stratified by vaccine type and outcome. We identified nine studies on PCV13 and six on PPV23. No new randomized clinical trials were identified. Due to different outcomes, it was not possible to do a meta-analysis. New high-quality observational studies indicate protective vaccine effectiveness for both vaccines against vaccine type pneumonia. Our estimates for the protective vaccine efficacy and effectiveness (VE) of PPV23 on pneumonia and pneumococcal pneumonia overlap with results from previously published reviews. Some of the results indicate that the effectiveness of the PPV23 is best in younger age groups, and that it decreases over time.https://www.mdpi.com/2076-0817/9/4/259pneumococcal vaccinesreviewinvasive pneumococcal diseasepneumoniaelderly |
| spellingShingle | Jacob Dag Berild Brita Askeland Winje Didrik Frimann Vestrheim Hans-Christian Slotved Palle Valentiner-Branth Adam Roth Jann Storsäter A Systematic Review of Studies Published between 2016 and 2019 on the Effectiveness and Efficacy of Pneumococcal Vaccination on Pneumonia and Invasive Pneumococcal Disease in an Elderly Population Pathogens pneumococcal vaccines review invasive pneumococcal disease pneumonia elderly |
| title | A Systematic Review of Studies Published between 2016 and 2019 on the Effectiveness and Efficacy of Pneumococcal Vaccination on Pneumonia and Invasive Pneumococcal Disease in an Elderly Population |
| title_full | A Systematic Review of Studies Published between 2016 and 2019 on the Effectiveness and Efficacy of Pneumococcal Vaccination on Pneumonia and Invasive Pneumococcal Disease in an Elderly Population |
| title_fullStr | A Systematic Review of Studies Published between 2016 and 2019 on the Effectiveness and Efficacy of Pneumococcal Vaccination on Pneumonia and Invasive Pneumococcal Disease in an Elderly Population |
| title_full_unstemmed | A Systematic Review of Studies Published between 2016 and 2019 on the Effectiveness and Efficacy of Pneumococcal Vaccination on Pneumonia and Invasive Pneumococcal Disease in an Elderly Population |
| title_short | A Systematic Review of Studies Published between 2016 and 2019 on the Effectiveness and Efficacy of Pneumococcal Vaccination on Pneumonia and Invasive Pneumococcal Disease in an Elderly Population |
| title_sort | systematic review of studies published between 2016 and 2019 on the effectiveness and efficacy of pneumococcal vaccination on pneumonia and invasive pneumococcal disease in an elderly population |
| topic | pneumococcal vaccines review invasive pneumococcal disease pneumonia elderly |
| url | https://www.mdpi.com/2076-0817/9/4/259 |
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