Impact of Solute Carrier Transporters in Glioma Pathology: A Comprehensive Review
Solute carriers (SLCs) are essential for brain physiology and homeostasis due to their role in transporting necessary substances across cell membranes. There is an increasing need to further unravel their pathophysiological implications since they have been proposed to play a pivotal role in brain t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/11/9393 |
| _version_ | 1797597425617076224 |
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| author | Filippos Anagnostakis Michail Kokkorakis Mariam Markouli Christina Piperi |
| author_facet | Filippos Anagnostakis Michail Kokkorakis Mariam Markouli Christina Piperi |
| author_sort | Filippos Anagnostakis |
| collection | DOAJ |
| description | Solute carriers (SLCs) are essential for brain physiology and homeostasis due to their role in transporting necessary substances across cell membranes. There is an increasing need to further unravel their pathophysiological implications since they have been proposed to play a pivotal role in brain tumor development, progression, and the formation of the tumor microenvironment (TME) through the upregulation and downregulation of various amino acid transporters. Due to their implication in malignancy and tumor progression, SLCs are currently positioned at the center of novel pharmacological targeting strategies and drug development. In this review, we discuss the key structural and functional characteristics of the main SLC family members involved in glioma pathogenesis, along with their potential targeting options to provide new opportunities for CNS drug design and more effective glioma management. |
| first_indexed | 2024-03-11T03:05:54Z |
| format | Article |
| id | doaj.art-a95b4ad1e68141f8b9cdd74a2d7c19f6 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T03:05:54Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-a95b4ad1e68141f8b9cdd74a2d7c19f62023-11-18T07:58:24ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-05-012411939310.3390/ijms24119393Impact of Solute Carrier Transporters in Glioma Pathology: A Comprehensive ReviewFilippos Anagnostakis0Michail Kokkorakis1Mariam Markouli2Christina Piperi3Department of Medical and Surgical Sciences, University of Bologna, 40126 Bologna, ItalyDepartment of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, 9700 RB Groningen, The NetherlandsDepartment of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118, USADepartment of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceSolute carriers (SLCs) are essential for brain physiology and homeostasis due to their role in transporting necessary substances across cell membranes. There is an increasing need to further unravel their pathophysiological implications since they have been proposed to play a pivotal role in brain tumor development, progression, and the formation of the tumor microenvironment (TME) through the upregulation and downregulation of various amino acid transporters. Due to their implication in malignancy and tumor progression, SLCs are currently positioned at the center of novel pharmacological targeting strategies and drug development. In this review, we discuss the key structural and functional characteristics of the main SLC family members involved in glioma pathogenesis, along with their potential targeting options to provide new opportunities for CNS drug design and more effective glioma management.https://www.mdpi.com/1422-0067/24/11/9393solute carrierstransportersSLCbrain tumorsgliomastumor microenvironment |
| spellingShingle | Filippos Anagnostakis Michail Kokkorakis Mariam Markouli Christina Piperi Impact of Solute Carrier Transporters in Glioma Pathology: A Comprehensive Review International Journal of Molecular Sciences solute carriers transporters SLC brain tumors gliomas tumor microenvironment |
| title | Impact of Solute Carrier Transporters in Glioma Pathology: A Comprehensive Review |
| title_full | Impact of Solute Carrier Transporters in Glioma Pathology: A Comprehensive Review |
| title_fullStr | Impact of Solute Carrier Transporters in Glioma Pathology: A Comprehensive Review |
| title_full_unstemmed | Impact of Solute Carrier Transporters in Glioma Pathology: A Comprehensive Review |
| title_short | Impact of Solute Carrier Transporters in Glioma Pathology: A Comprehensive Review |
| title_sort | impact of solute carrier transporters in glioma pathology a comprehensive review |
| topic | solute carriers transporters SLC brain tumors gliomas tumor microenvironment |
| url | https://www.mdpi.com/1422-0067/24/11/9393 |
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