Neuroprotective Effect of Ketone Metabolism on Inhibiting Inflammatory Response by Regulating Macrophage Polarization After Acute Cervical Spinal Cord Injury in Rats

Neuroprotective Effect of Ketone Metabolism on Inhibiting Inflammatory Response by Regulating Macrophage Polarization After Acute Cervical Spinal Cord Injury in Rats

ObjectiveTo investigate the effects of ketogenic metabolism on macrophage polarization, inflammation inhibition, and function recovery after acute spinal cord injury (SCI) in rats.MethodsSixty-four adult male Sprague–Dawley rats were randomly and equally divided into sham, standard diet (SD), ketone...

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Bibliographic Details
Main Authors: Junyu Lin, Zucheng Huang, Junhao Liu, Zhiping Huang, Yapu Liu, Qi Liu, Zhou Yang, Ruoyao Li, Xiuhua Wu, Zhe Shi, Qingan Zhu, Xiaoliang Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Neuroscience
Subjects:
spinal cord injury
ketone metabolism
ketogenic diet
inflammation
macrophage
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2020.583611/full

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