Establishment of wMel Wolbachia in Aedes aegypti mosquitoes and reduction of local dengue transmission in Cairns and surrounding locations in northern Queensland, Australia [version 2; peer review: 2 approved]
Background: The wMel strain of Wolbachia has been successfully introduced into Aedes aegypti mosquitoes and subsequently shown in laboratory studies to reduce transmission of a range of viruses including dengue, Zika, chikungunya, yellow fever, and Mayaro viruses that cause human disease. Here we re...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2020-04-01
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| Series: | Gates Open Research |
| Online Access: | https://gatesopenresearch.org/articles/3-1547/v2 |
| _version_ | 1818991752557625344 |
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| author | Peter A. Ryan Andrew P. Turley Geoff Wilson Tim P. Hurst Kate Retzki Jack Brown-Kenyon Lauren Hodgson Nichola Kenny Helen Cook Brian L. Montgomery Christopher J. Paton Scott A. Ritchie Ary A. Hoffmann Nicholas P. Jewell Stephanie K. Tanamas Katherine L. Anders Cameron P. Simmons Scott L. O’Neill |
| author_facet | Peter A. Ryan Andrew P. Turley Geoff Wilson Tim P. Hurst Kate Retzki Jack Brown-Kenyon Lauren Hodgson Nichola Kenny Helen Cook Brian L. Montgomery Christopher J. Paton Scott A. Ritchie Ary A. Hoffmann Nicholas P. Jewell Stephanie K. Tanamas Katherine L. Anders Cameron P. Simmons Scott L. O’Neill |
| author_sort | Peter A. Ryan |
| collection | DOAJ |
| description | Background: The wMel strain of Wolbachia has been successfully introduced into Aedes aegypti mosquitoes and subsequently shown in laboratory studies to reduce transmission of a range of viruses including dengue, Zika, chikungunya, yellow fever, and Mayaro viruses that cause human disease. Here we report the entomological and epidemiological outcomes of staged deployment of Wolbachia across nearly all significant dengue transmission risk areas in Australia. Methods: The wMel strain of Wolbachia was backcrossed into the local Aedes aegypti genotype (Cairns and Townsville backgrounds) and mosquitoes were released in the field by staff or via community assisted methods. Mosquito monitoring was undertaken and mosquitoes were screened for the presence of Wolbachia. Dengue case notifications were used to track dengue incidence in each location before and after releases. Results: Empirical analyses of the Wolbachia mosquito releases, including data on the density, frequency and duration of Wolbachia mosquito releases, indicate that Wolbachia can be readily established in local mosquito populations, using a variety of deployment options and over short release durations (mean release period 11 weeks, range 2-22 weeks). Importantly, Wolbachia frequencies have remained stable in mosquito populations since releases for up to 8 years. Analysis of dengue case notifications data demonstrates near-elimination of local dengue transmission for the past five years in locations where Wolbachia has been established. The regression model estimate of Wolbachia intervention effect from interrupted time series analyses of case notifications data prior to and after releases, indicated a 96% reduction in dengue incidence in Wolbachia treated populations (95% confidence interval: 84 – 99%). Conclusion: Deployment of the wMel strain of Wolbachia into local Ae. aegypti populations across the Australian regional cities of Cairns and most smaller regional communities with a past history of dengue has resulted in the reduction of local dengue transmission across all deployment areas. |
| first_indexed | 2024-12-20T20:15:16Z |
| format | Article |
| id | doaj.art-a95e41f91b89408aa0b25e52189d3f4a |
| institution | Directory Open Access Journal |
| issn | 2572-4754 |
| language | English |
| last_indexed | 2024-12-20T20:15:16Z |
| publishDate | 2020-04-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | Gates Open Research |
| spelling | doaj.art-a95e41f91b89408aa0b25e52189d3f4a2022-12-21T19:27:43ZengF1000 Research LtdGates Open Research2572-47542020-04-01310.12688/gatesopenres.13061.214275Establishment of wMel Wolbachia in Aedes aegypti mosquitoes and reduction of local dengue transmission in Cairns and surrounding locations in northern Queensland, Australia [version 2; peer review: 2 approved]Peter A. Ryan0Andrew P. Turley1Geoff Wilson2Tim P. Hurst3Kate Retzki4Jack Brown-Kenyon5Lauren Hodgson6Nichola Kenny7Helen Cook8Brian L. Montgomery9Christopher J. Paton10Scott A. Ritchie11Ary A. Hoffmann12Nicholas P. Jewell13Stephanie K. Tanamas14Katherine L. Anders15Cameron P. Simmons16Scott L. O’Neill17Institute of Vector-Borne Disease, Monash University, Clayton, Victoria, 3800, AustraliaInstitute of Vector-Borne Disease, Monash University, Clayton, Victoria, 3800, AustraliaInstitute of Vector-Borne Disease, Monash University, Clayton, Victoria, 3800, AustraliaInstitute of Vector-Borne Disease, Monash University, Clayton, Victoria, 3800, AustraliaInstitute of Vector-Borne Disease, Monash University, Clayton, Victoria, 3800, AustraliaInstitute of Vector-Borne Disease, Monash University, Clayton, Victoria, 3800, AustraliaInstitute of Vector-Borne Disease, Monash University, Clayton, Victoria, 3800, AustraliaInstitute of Vector-Borne Disease, Monash University, Clayton, Victoria, 3800, AustraliaInstitute of Vector-Borne Disease, Monash University, Clayton, Victoria, 3800, AustraliaInstitute of Vector-Borne Disease, Monash University, Clayton, Victoria, 3800, AustraliaCollege of Public Health, Medical and Veterinary Sciences, James Cook University, Cairns, Queensland, AustraliaInstitute of Vector-Borne Disease, Monash University, Clayton, Victoria, 3800, AustraliaSchool of Biosciences, Bio21 Institute, University of Melbourne, Parkville, Victoria, AustraliaDivision of Epidemiology and Biostatistics, School of Public Health, University of California, Berkeley, California, USAInstitute of Vector-Borne Disease, Monash University, Clayton, Victoria, 3800, AustraliaInstitute of Vector-Borne Disease, Monash University, Clayton, Victoria, 3800, AustraliaInstitute of Vector-Borne Disease, Monash University, Clayton, Victoria, 3800, AustraliaInstitute of Vector-Borne Disease, Monash University, Clayton, Victoria, 3800, AustraliaBackground: The wMel strain of Wolbachia has been successfully introduced into Aedes aegypti mosquitoes and subsequently shown in laboratory studies to reduce transmission of a range of viruses including dengue, Zika, chikungunya, yellow fever, and Mayaro viruses that cause human disease. Here we report the entomological and epidemiological outcomes of staged deployment of Wolbachia across nearly all significant dengue transmission risk areas in Australia. Methods: The wMel strain of Wolbachia was backcrossed into the local Aedes aegypti genotype (Cairns and Townsville backgrounds) and mosquitoes were released in the field by staff or via community assisted methods. Mosquito monitoring was undertaken and mosquitoes were screened for the presence of Wolbachia. Dengue case notifications were used to track dengue incidence in each location before and after releases. Results: Empirical analyses of the Wolbachia mosquito releases, including data on the density, frequency and duration of Wolbachia mosquito releases, indicate that Wolbachia can be readily established in local mosquito populations, using a variety of deployment options and over short release durations (mean release period 11 weeks, range 2-22 weeks). Importantly, Wolbachia frequencies have remained stable in mosquito populations since releases for up to 8 years. Analysis of dengue case notifications data demonstrates near-elimination of local dengue transmission for the past five years in locations where Wolbachia has been established. The regression model estimate of Wolbachia intervention effect from interrupted time series analyses of case notifications data prior to and after releases, indicated a 96% reduction in dengue incidence in Wolbachia treated populations (95% confidence interval: 84 – 99%). Conclusion: Deployment of the wMel strain of Wolbachia into local Ae. aegypti populations across the Australian regional cities of Cairns and most smaller regional communities with a past history of dengue has resulted in the reduction of local dengue transmission across all deployment areas.https://gatesopenresearch.org/articles/3-1547/v2 |
| spellingShingle | Peter A. Ryan Andrew P. Turley Geoff Wilson Tim P. Hurst Kate Retzki Jack Brown-Kenyon Lauren Hodgson Nichola Kenny Helen Cook Brian L. Montgomery Christopher J. Paton Scott A. Ritchie Ary A. Hoffmann Nicholas P. Jewell Stephanie K. Tanamas Katherine L. Anders Cameron P. Simmons Scott L. O’Neill Establishment of wMel Wolbachia in Aedes aegypti mosquitoes and reduction of local dengue transmission in Cairns and surrounding locations in northern Queensland, Australia [version 2; peer review: 2 approved] Gates Open Research |
| title | Establishment of wMel Wolbachia in Aedes aegypti mosquitoes and reduction of local dengue transmission in Cairns and surrounding locations in northern Queensland, Australia [version 2; peer review: 2 approved] |
| title_full | Establishment of wMel Wolbachia in Aedes aegypti mosquitoes and reduction of local dengue transmission in Cairns and surrounding locations in northern Queensland, Australia [version 2; peer review: 2 approved] |
| title_fullStr | Establishment of wMel Wolbachia in Aedes aegypti mosquitoes and reduction of local dengue transmission in Cairns and surrounding locations in northern Queensland, Australia [version 2; peer review: 2 approved] |
| title_full_unstemmed | Establishment of wMel Wolbachia in Aedes aegypti mosquitoes and reduction of local dengue transmission in Cairns and surrounding locations in northern Queensland, Australia [version 2; peer review: 2 approved] |
| title_short | Establishment of wMel Wolbachia in Aedes aegypti mosquitoes and reduction of local dengue transmission in Cairns and surrounding locations in northern Queensland, Australia [version 2; peer review: 2 approved] |
| title_sort | establishment of wmel wolbachia in aedes aegypti mosquitoes and reduction of local dengue transmission in cairns and surrounding locations in northern queensland australia version 2 peer review 2 approved |
| url | https://gatesopenresearch.org/articles/3-1547/v2 |
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