p53 wild-type colorectal cancer cells that express a fetal gene signature are associated with metastasis and poor prognosis
The failure of chemotherapy in colorectal cancer is currently unclear. Here, the authors show that upon sub-lethal dose of chemotherapy wild-type p53 colorectal cancers acquire a quiescence-like phenotype and a YAP-dependent fetal-like intestinal stem cell state associated with a higher metastatic a...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30382-9 |
| _version_ | 1828794382603517952 |
|---|---|
| author | Laura Solé Teresa Lobo-Jarne Daniel Álvarez-Villanueva Josune Alonso-Marañón Yolanda Guillén Marta Guix Irene Sangrador Catalina Rozalén Anna Vert Antonio Barbachano Joan Lop Marta Salido Beatriz Bellosillo Raquel García-Romero Marta Garrido Jessica González María Martínez-Iniesta Erika López-Arribillaga Ramón Salazar Clara Montagut Ferrán Torres Mar Iglesias Toni Celià-Terrassa Alberto Muñoz Alberto Villanueva Anna Bigas Lluís Espinosa |
| author_facet | Laura Solé Teresa Lobo-Jarne Daniel Álvarez-Villanueva Josune Alonso-Marañón Yolanda Guillén Marta Guix Irene Sangrador Catalina Rozalén Anna Vert Antonio Barbachano Joan Lop Marta Salido Beatriz Bellosillo Raquel García-Romero Marta Garrido Jessica González María Martínez-Iniesta Erika López-Arribillaga Ramón Salazar Clara Montagut Ferrán Torres Mar Iglesias Toni Celià-Terrassa Alberto Muñoz Alberto Villanueva Anna Bigas Lluís Espinosa |
| author_sort | Laura Solé |
| collection | DOAJ |
| description | The failure of chemotherapy in colorectal cancer is currently unclear. Here, the authors show that upon sub-lethal dose of chemotherapy wild-type p53 colorectal cancers acquire a quiescence-like phenotype and a YAP-dependent fetal-like intestinal stem cell state associated with a higher metastatic activity and poor prognosis in patients. |
| first_indexed | 2024-12-12T03:44:23Z |
| format | Article |
| id | doaj.art-a95e4335e7804b569fac9baa390c372b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-12T03:44:23Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a95e4335e7804b569fac9baa390c372b2022-12-22T00:39:36ZengNature PortfolioNature Communications2041-17232022-05-0113111510.1038/s41467-022-30382-9p53 wild-type colorectal cancer cells that express a fetal gene signature are associated with metastasis and poor prognosisLaura Solé0Teresa Lobo-Jarne1Daniel Álvarez-Villanueva2Josune Alonso-Marañón3Yolanda Guillén4Marta Guix5Irene Sangrador6Catalina Rozalén7Anna Vert8Antonio Barbachano9Joan Lop10Marta Salido11Beatriz Bellosillo12Raquel García-Romero13Marta Garrido14Jessica González15María Martínez-Iniesta16Erika López-Arribillaga17Ramón Salazar18Clara Montagut19Ferrán Torres20Mar Iglesias21Toni Celià-Terrassa22Alberto Muñoz23Alberto Villanueva24Anna Bigas25Lluís Espinosa26Cancer Research Program, Institut Mar d’Investigacions Mèdiques, CIBERONC, Hospital del MarCancer Research Program, Institut Mar d’Investigacions Mèdiques, CIBERONC, Hospital del MarCancer Research Program, Institut Mar d’Investigacions Mèdiques, CIBERONC, Hospital del MarCancer Research Program, Institut Mar d’Investigacions Mèdiques, CIBERONC, Hospital del MarCancer Research Program, Institut Mar d’Investigacions Mèdiques, CIBERONC, Hospital del MarDepartment of Oncology, Institut Mar d’Investigacions Mèdiques, CIBERONC, Universitat Pompeu FabraCancer Research Program, Institut Mar d’Investigacions Mèdiques, CIBERONC, Hospital del MarCancer Research Program, Institut Mar d’Investigacions Mèdiques, CIBERONC, Hospital del MarCancer Research Program, Institut Mar d’Investigacions Mèdiques, CIBERONC, Hospital del MarCIBERONC, Instituto de Salud Carlos IIIDepartment of Pathology, Institut Mar d’Investigacions Mèdiques, Universitat Autònoma de BarcelonaDepartment of Pathology, Institut Mar d’Investigacions Mèdiques, Universitat Autònoma de BarcelonaCIBERONC, Instituto de Salud Carlos IIICancer Research Program, Institut Mar d’Investigacions Mèdiques, CIBERONC, Hospital del MarCancer Research Program, Institut Mar d’Investigacions Mèdiques, CIBERONC, Hospital del MarCancer Research Program, Institut Mar d’Investigacions Mèdiques, CIBERONC, Hospital del MarChemoresistance and Predictive Factors Group, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet del LlobregatCancer Research Program, Institut Mar d’Investigacions Mèdiques, CIBERONC, Hospital del MarCIBERONC, Instituto de Salud Carlos IIICIBERONC, Instituto de Salud Carlos IIIBiostatistics Unit, Medical School, Universitat Autònoma de BarcelonaCIBERONC, Instituto de Salud Carlos IIICancer Research Program, Institut Mar d’Investigacions Mèdiques, CIBERONC, Hospital del MarCIBERONC, Instituto de Salud Carlos IIIChemoresistance and Predictive Factors Group, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet del LlobregatCancer Research Program, Institut Mar d’Investigacions Mèdiques, CIBERONC, Hospital del MarCancer Research Program, Institut Mar d’Investigacions Mèdiques, CIBERONC, Hospital del MarThe failure of chemotherapy in colorectal cancer is currently unclear. Here, the authors show that upon sub-lethal dose of chemotherapy wild-type p53 colorectal cancers acquire a quiescence-like phenotype and a YAP-dependent fetal-like intestinal stem cell state associated with a higher metastatic activity and poor prognosis in patients.https://doi.org/10.1038/s41467-022-30382-9 |
| spellingShingle | Laura Solé Teresa Lobo-Jarne Daniel Álvarez-Villanueva Josune Alonso-Marañón Yolanda Guillén Marta Guix Irene Sangrador Catalina Rozalén Anna Vert Antonio Barbachano Joan Lop Marta Salido Beatriz Bellosillo Raquel García-Romero Marta Garrido Jessica González María Martínez-Iniesta Erika López-Arribillaga Ramón Salazar Clara Montagut Ferrán Torres Mar Iglesias Toni Celià-Terrassa Alberto Muñoz Alberto Villanueva Anna Bigas Lluís Espinosa p53 wild-type colorectal cancer cells that express a fetal gene signature are associated with metastasis and poor prognosis Nature Communications |
| title | p53 wild-type colorectal cancer cells that express a fetal gene signature are associated with metastasis and poor prognosis |
| title_full | p53 wild-type colorectal cancer cells that express a fetal gene signature are associated with metastasis and poor prognosis |
| title_fullStr | p53 wild-type colorectal cancer cells that express a fetal gene signature are associated with metastasis and poor prognosis |
| title_full_unstemmed | p53 wild-type colorectal cancer cells that express a fetal gene signature are associated with metastasis and poor prognosis |
| title_short | p53 wild-type colorectal cancer cells that express a fetal gene signature are associated with metastasis and poor prognosis |
| title_sort | p53 wild type colorectal cancer cells that express a fetal gene signature are associated with metastasis and poor prognosis |
| url | https://doi.org/10.1038/s41467-022-30382-9 |
| work_keys_str_mv | AT laurasole p53wildtypecolorectalcancercellsthatexpressafetalgenesignatureareassociatedwithmetastasisandpoorprognosis AT teresalobojarne p53wildtypecolorectalcancercellsthatexpressafetalgenesignatureareassociatedwithmetastasisandpoorprognosis AT danielalvarezvillanueva p53wildtypecolorectalcancercellsthatexpressafetalgenesignatureareassociatedwithmetastasisandpoorprognosis AT josunealonsomaranon p53wildtypecolorectalcancercellsthatexpressafetalgenesignatureareassociatedwithmetastasisandpoorprognosis AT yolandaguillen p53wildtypecolorectalcancercellsthatexpressafetalgenesignatureareassociatedwithmetastasisandpoorprognosis AT martaguix p53wildtypecolorectalcancercellsthatexpressafetalgenesignatureareassociatedwithmetastasisandpoorprognosis AT irenesangrador p53wildtypecolorectalcancercellsthatexpressafetalgenesignatureareassociatedwithmetastasisandpoorprognosis AT catalinarozalen p53wildtypecolorectalcancercellsthatexpressafetalgenesignatureareassociatedwithmetastasisandpoorprognosis AT annavert p53wildtypecolorectalcancercellsthatexpressafetalgenesignatureareassociatedwithmetastasisandpoorprognosis AT antoniobarbachano p53wildtypecolorectalcancercellsthatexpressafetalgenesignatureareassociatedwithmetastasisandpoorprognosis AT joanlop p53wildtypecolorectalcancercellsthatexpressafetalgenesignatureareassociatedwithmetastasisandpoorprognosis AT martasalido p53wildtypecolorectalcancercellsthatexpressafetalgenesignatureareassociatedwithmetastasisandpoorprognosis AT beatrizbellosillo p53wildtypecolorectalcancercellsthatexpressafetalgenesignatureareassociatedwithmetastasisandpoorprognosis AT raquelgarciaromero p53wildtypecolorectalcancercellsthatexpressafetalgenesignatureareassociatedwithmetastasisandpoorprognosis AT martagarrido p53wildtypecolorectalcancercellsthatexpressafetalgenesignatureareassociatedwithmetastasisandpoorprognosis AT jessicagonzalez p53wildtypecolorectalcancercellsthatexpressafetalgenesignatureareassociatedwithmetastasisandpoorprognosis AT mariamartineziniesta p53wildtypecolorectalcancercellsthatexpressafetalgenesignatureareassociatedwithmetastasisandpoorprognosis AT erikalopezarribillaga p53wildtypecolorectalcancercellsthatexpressafetalgenesignatureareassociatedwithmetastasisandpoorprognosis AT ramonsalazar p53wildtypecolorectalcancercellsthatexpressafetalgenesignatureareassociatedwithmetastasisandpoorprognosis AT claramontagut p53wildtypecolorectalcancercellsthatexpressafetalgenesignatureareassociatedwithmetastasisandpoorprognosis AT ferrantorres p53wildtypecolorectalcancercellsthatexpressafetalgenesignatureareassociatedwithmetastasisandpoorprognosis AT mariglesias p53wildtypecolorectalcancercellsthatexpressafetalgenesignatureareassociatedwithmetastasisandpoorprognosis AT toniceliaterrassa p53wildtypecolorectalcancercellsthatexpressafetalgenesignatureareassociatedwithmetastasisandpoorprognosis AT albertomunoz p53wildtypecolorectalcancercellsthatexpressafetalgenesignatureareassociatedwithmetastasisandpoorprognosis AT albertovillanueva p53wildtypecolorectalcancercellsthatexpressafetalgenesignatureareassociatedwithmetastasisandpoorprognosis AT annabigas p53wildtypecolorectalcancercellsthatexpressafetalgenesignatureareassociatedwithmetastasisandpoorprognosis AT lluisespinosa p53wildtypecolorectalcancercellsthatexpressafetalgenesignatureareassociatedwithmetastasisandpoorprognosis |