Sterile inflammation and the NLRP3 inflammasome in cardiometabolic disease
Inflammation plays an important role in the pathophysiology of cardiometabolic diseases. Sterile inflammation, a non-infectious and damage-associated molecular pattern (DAMP)-induced innate response, is now well-established to be closely associated with development and progression of cardiometabolic...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Biomedical Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2319417023000616 |
| _version_ | 1827776245262188544 |
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| author | Sungji Cho Fan Ying Gary Sweeney |
| author_facet | Sungji Cho Fan Ying Gary Sweeney |
| author_sort | Sungji Cho |
| collection | DOAJ |
| description | Inflammation plays an important role in the pathophysiology of cardiometabolic diseases. Sterile inflammation, a non-infectious and damage-associated molecular pattern (DAMP)-induced innate response, is now well-established to be closely associated with development and progression of cardiometabolic diseases. The NOD-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) inflammasome is well-established as a major player in sterile inflammatory responses. It is a multimeric cytosolic protein complex which regulates the activation of caspase-1 and subsequently promotes cleavage and release of interleukin (IL)-1 family cytokines, which have a deleterious impact on the development of cardiometabolic diseases. Therefore, targeting NLRP3 itself or the downstream consequences of NLRP3 activation represent excellent potential therapeutic targets in inflammatory cardiometabolic diseases. Here, we review our current understanding of the role which NLRP3 inflammasome regulation plays in cardiometabolic diseases such as obesity, diabetes, non-alcoholic steatohepatitis (NASH), atherosclerosis, ischemic heart disease and cardiomyopathy. Finally, we highlight the potential of targeting NLPR3 or related signaling molecules as a therapeutic approach. |
| first_indexed | 2024-03-11T14:02:18Z |
| format | Article |
| id | doaj.art-a95f357c65714e21b6e18846b4226d6f |
| institution | Directory Open Access Journal |
| issn | 2319-4170 |
| language | English |
| last_indexed | 2024-03-11T14:02:18Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedical Journal |
| spelling | doaj.art-a95f357c65714e21b6e18846b4226d6f2023-11-02T04:13:35ZengElsevierBiomedical Journal2319-41702023-10-01465100624Sterile inflammation and the NLRP3 inflammasome in cardiometabolic diseaseSungji Cho0Fan Ying1Gary Sweeney2Department of Biology, York University, Toronto, Ontario, CanadaDepartment of Biology, York University, Toronto, Ontario, CanadaCorresponding author. Department of Biology, York University, 4700 Keele Str., Toronto, Ontario, Canada.; Department of Biology, York University, Toronto, Ontario, CanadaInflammation plays an important role in the pathophysiology of cardiometabolic diseases. Sterile inflammation, a non-infectious and damage-associated molecular pattern (DAMP)-induced innate response, is now well-established to be closely associated with development and progression of cardiometabolic diseases. The NOD-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) inflammasome is well-established as a major player in sterile inflammatory responses. It is a multimeric cytosolic protein complex which regulates the activation of caspase-1 and subsequently promotes cleavage and release of interleukin (IL)-1 family cytokines, which have a deleterious impact on the development of cardiometabolic diseases. Therefore, targeting NLRP3 itself or the downstream consequences of NLRP3 activation represent excellent potential therapeutic targets in inflammatory cardiometabolic diseases. Here, we review our current understanding of the role which NLRP3 inflammasome regulation plays in cardiometabolic diseases such as obesity, diabetes, non-alcoholic steatohepatitis (NASH), atherosclerosis, ischemic heart disease and cardiomyopathy. Finally, we highlight the potential of targeting NLPR3 or related signaling molecules as a therapeutic approach.http://www.sciencedirect.com/science/article/pii/S2319417023000616Sterile inflammationNLRP3 inflammasomeCardiometabolic diseases |
| spellingShingle | Sungji Cho Fan Ying Gary Sweeney Sterile inflammation and the NLRP3 inflammasome in cardiometabolic disease Biomedical Journal Sterile inflammation NLRP3 inflammasome Cardiometabolic diseases |
| title | Sterile inflammation and the NLRP3 inflammasome in cardiometabolic disease |
| title_full | Sterile inflammation and the NLRP3 inflammasome in cardiometabolic disease |
| title_fullStr | Sterile inflammation and the NLRP3 inflammasome in cardiometabolic disease |
| title_full_unstemmed | Sterile inflammation and the NLRP3 inflammasome in cardiometabolic disease |
| title_short | Sterile inflammation and the NLRP3 inflammasome in cardiometabolic disease |
| title_sort | sterile inflammation and the nlrp3 inflammasome in cardiometabolic disease |
| topic | Sterile inflammation NLRP3 inflammasome Cardiometabolic diseases |
| url | http://www.sciencedirect.com/science/article/pii/S2319417023000616 |
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