Immunomodulators and microRNAs as neurorestorative therapy for ischemic stroke
Most of all strokes are ischemic due to occlusion of a vessel, and comprise two main types, thrombotic and embolic. Inflammation and immune response play an important role in the outcome of ischemic stroke. Pharmaceutical and cell-based therapies with immunomodulatory properties could be of benefit...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=6;spage=865;epage=874;aulast=Martinez |
| _version_ | 1818305868642385920 |
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| author | Bridget Martinez Philip V Peplow |
| author_facet | Bridget Martinez Philip V Peplow |
| author_sort | Bridget Martinez |
| collection | DOAJ |
| description | Most of all strokes are ischemic due to occlusion of a vessel, and comprise two main types, thrombotic and embolic. Inflammation and immune response play an important role in the outcome of ischemic stroke. Pharmaceutical and cell-based therapies with immunomodulatory properties could be of benefit in treating ischemic stroke. Possible changes in microRNAs brought about by immunomodulatory treatments may be important. The pharmaceutical studies described in this review have identified several differentially regulated miRNAs associated with disregulation of mRNA targets or the upregulation of several neuroprotective genes, thereby highlighting the potential neuroprotective roles of specific miRNAs such as miR-762, -1892, -200a, -145. MiR-124, -711, -145 are the strongly associated miRNAs predicted to mediate anti-inflammatory pathways and microglia/macrophage M2-like activation phenotype. The cell-based therapy studies reviewed have mainly utilized mesenchymal stem cells or human umbilical cord blood cells and shown to improve functional and neurological outcomes in stroke animals. MiR-145 and miR-133b were implicated in nerve cell remodeling and functional recovery after stroke. Human umbilical cord blood cells decreased proinflammatory factors and promoted M2 macrophage polarization in stroke diabetic animals. |
| first_indexed | 2024-12-13T06:33:26Z |
| format | Article |
| id | doaj.art-a9618308c7ce4d9084908da36c4267de |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-13T06:33:26Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-a9618308c7ce4d9084908da36c4267de2022-12-21T23:56:33ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742017-01-0112686587410.4103/1673-5374.208540Immunomodulators and microRNAs as neurorestorative therapy for ischemic strokeBridget MartinezPhilip V PeplowMost of all strokes are ischemic due to occlusion of a vessel, and comprise two main types, thrombotic and embolic. Inflammation and immune response play an important role in the outcome of ischemic stroke. Pharmaceutical and cell-based therapies with immunomodulatory properties could be of benefit in treating ischemic stroke. Possible changes in microRNAs brought about by immunomodulatory treatments may be important. The pharmaceutical studies described in this review have identified several differentially regulated miRNAs associated with disregulation of mRNA targets or the upregulation of several neuroprotective genes, thereby highlighting the potential neuroprotective roles of specific miRNAs such as miR-762, -1892, -200a, -145. MiR-124, -711, -145 are the strongly associated miRNAs predicted to mediate anti-inflammatory pathways and microglia/macrophage M2-like activation phenotype. The cell-based therapy studies reviewed have mainly utilized mesenchymal stem cells or human umbilical cord blood cells and shown to improve functional and neurological outcomes in stroke animals. MiR-145 and miR-133b were implicated in nerve cell remodeling and functional recovery after stroke. Human umbilical cord blood cells decreased proinflammatory factors and promoted M2 macrophage polarization in stroke diabetic animals.http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=6;spage=865;epage=874;aulast=Martinezischemic stroke; immunomodulators; pharmaceutical therapies; cell-based therapies; microRNAs; animal models |
| spellingShingle | Bridget Martinez Philip V Peplow Immunomodulators and microRNAs as neurorestorative therapy for ischemic stroke Neural Regeneration Research ischemic stroke; immunomodulators; pharmaceutical therapies; cell-based therapies; microRNAs; animal models |
| title | Immunomodulators and microRNAs as neurorestorative therapy for ischemic stroke |
| title_full | Immunomodulators and microRNAs as neurorestorative therapy for ischemic stroke |
| title_fullStr | Immunomodulators and microRNAs as neurorestorative therapy for ischemic stroke |
| title_full_unstemmed | Immunomodulators and microRNAs as neurorestorative therapy for ischemic stroke |
| title_short | Immunomodulators and microRNAs as neurorestorative therapy for ischemic stroke |
| title_sort | immunomodulators and micrornas as neurorestorative therapy for ischemic stroke |
| topic | ischemic stroke; immunomodulators; pharmaceutical therapies; cell-based therapies; microRNAs; animal models |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=6;spage=865;epage=874;aulast=Martinez |
| work_keys_str_mv | AT bridgetmartinez immunomodulatorsandmicrornasasneurorestorativetherapyforischemicstroke AT philipvpeplow immunomodulatorsandmicrornasasneurorestorativetherapyforischemicstroke |