NIR-II Absorbing Conjugated Polymer Nanotheranostics for Thermal Initiated NO Enhanced Photothermal Therapy
Photothermal therapy (PTT) has received constant attention as a promising cancer treatment. However, PTT-induced inflammation can limit its effectiveness. To address this shortcoming, we developed second near-infrared (NIR-II) light-activated nanotheranostics (CPNPBs), which include a thermosensitiv...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/13/6/642 |
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| author | Kaiwen Chang Xiaolin Sun Qiaofang Qi Mingying Fu Bing Han Yang Zhang Wei Zhao Tianjun Ni Qiong Li Zhijun Yang Chunpo Ge |
| author_facet | Kaiwen Chang Xiaolin Sun Qiaofang Qi Mingying Fu Bing Han Yang Zhang Wei Zhao Tianjun Ni Qiong Li Zhijun Yang Chunpo Ge |
| author_sort | Kaiwen Chang |
| collection | DOAJ |
| description | Photothermal therapy (PTT) has received constant attention as a promising cancer treatment. However, PTT-induced inflammation can limit its effectiveness. To address this shortcoming, we developed second near-infrared (NIR-II) light-activated nanotheranostics (CPNPBs), which include a thermosensitive nitric oxide (NO) donor (BNN6) to enhance PTT. Under a 1064 nm laser irradiation, the conjugated polymer in CPNPBs serves as a photothermal agent for photothermal conversion, and the generated heat triggers the decomposition of BNN6 to release NO. The combination of hyperthermia and NO generation under single NIR-II laser irradiation allows enhanced thermal ablation of tumors. Consequently, CPNPBs can be exploited as potential candidates for NO-enhanced PTT, holding great promise for their clinical translational development. |
| first_indexed | 2024-03-11T02:42:03Z |
| format | Article |
| id | doaj.art-a9618fe815164f07bffcf4122ba62592 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-11T02:42:03Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-a9618fe815164f07bffcf4122ba625922023-11-18T09:33:06ZengMDPI AGBiosensors2079-63742023-06-0113664210.3390/bios13060642NIR-II Absorbing Conjugated Polymer Nanotheranostics for Thermal Initiated NO Enhanced Photothermal TherapyKaiwen Chang0Xiaolin Sun1Qiaofang Qi2Mingying Fu3Bing Han4Yang Zhang5Wei Zhao6Tianjun Ni7Qiong Li8Zhijun Yang9Chunpo Ge10Key Laboratory of Medical Molecular Probes, Department of Medical Chemistry, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, ChinaKey Laboratory of Medical Molecular Probes, Department of Medical Chemistry, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, ChinaKey Laboratory of Medical Molecular Probes, Department of Medical Chemistry, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, ChinaKey Laboratory of Medical Molecular Probes, Department of Medical Chemistry, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, ChinaKey Laboratory of Medical Molecular Probes, Department of Medical Chemistry, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, ChinaKey Laboratory of Medical Molecular Probes, Department of Medical Chemistry, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, ChinaKey Laboratory of Medical Molecular Probes, Department of Medical Chemistry, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, ChinaKey Laboratory of Medical Molecular Probes, Department of Medical Chemistry, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, ChinaShandong Provincial Key Laboratory of Detection Technology for Tumor Markers, College of Medicine, Linyi University, Linyi 276005, ChinaKey Laboratory of Medical Molecular Probes, Department of Medical Chemistry, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, ChinaKey Laboratory of Medical Molecular Probes, Department of Medical Chemistry, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, ChinaPhotothermal therapy (PTT) has received constant attention as a promising cancer treatment. However, PTT-induced inflammation can limit its effectiveness. To address this shortcoming, we developed second near-infrared (NIR-II) light-activated nanotheranostics (CPNPBs), which include a thermosensitive nitric oxide (NO) donor (BNN6) to enhance PTT. Under a 1064 nm laser irradiation, the conjugated polymer in CPNPBs serves as a photothermal agent for photothermal conversion, and the generated heat triggers the decomposition of BNN6 to release NO. The combination of hyperthermia and NO generation under single NIR-II laser irradiation allows enhanced thermal ablation of tumors. Consequently, CPNPBs can be exploited as potential candidates for NO-enhanced PTT, holding great promise for their clinical translational development.https://www.mdpi.com/2079-6374/13/6/642conjugated polymernanotheranosticsphotothermal therapyNIR-IInitric oxide |
| spellingShingle | Kaiwen Chang Xiaolin Sun Qiaofang Qi Mingying Fu Bing Han Yang Zhang Wei Zhao Tianjun Ni Qiong Li Zhijun Yang Chunpo Ge NIR-II Absorbing Conjugated Polymer Nanotheranostics for Thermal Initiated NO Enhanced Photothermal Therapy Biosensors conjugated polymer nanotheranostics photothermal therapy NIR-II nitric oxide |
| title | NIR-II Absorbing Conjugated Polymer Nanotheranostics for Thermal Initiated NO Enhanced Photothermal Therapy |
| title_full | NIR-II Absorbing Conjugated Polymer Nanotheranostics for Thermal Initiated NO Enhanced Photothermal Therapy |
| title_fullStr | NIR-II Absorbing Conjugated Polymer Nanotheranostics for Thermal Initiated NO Enhanced Photothermal Therapy |
| title_full_unstemmed | NIR-II Absorbing Conjugated Polymer Nanotheranostics for Thermal Initiated NO Enhanced Photothermal Therapy |
| title_short | NIR-II Absorbing Conjugated Polymer Nanotheranostics for Thermal Initiated NO Enhanced Photothermal Therapy |
| title_sort | nir ii absorbing conjugated polymer nanotheranostics for thermal initiated no enhanced photothermal therapy |
| topic | conjugated polymer nanotheranostics photothermal therapy NIR-II nitric oxide |
| url | https://www.mdpi.com/2079-6374/13/6/642 |
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