Muc2-dependent microbial colonization of the jejunal mucus layer is diet sensitive and confers local resistance to enteric pathogen infection

Muc2-dependent microbial colonization of the jejunal mucus layer is diet sensitive and confers local resistance to enteric pathogen infection

Summary: Intestinal mucus barriers normally prevent microbial infections but are sensitive to diet-dependent changes in the luminal environment. Here we demonstrate that mice fed a Western-style diet (WSD) suffer regiospecific failure of the mucus barrier in the small intestinal jejunum caused by di...

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Bibliographic Details
Main Authors: George M.H. Birchenough, Bjoern O. Schroeder, Sinan Sharba, Liisa Arike, Christian V. Recktenwald, Fabiola Puértolas-Balint, Mahadevan V. Subramani, Karl T. Hansson, Bahtiyar Yilmaz, Sara K. Lindén, Fredrik Bäckhed, Gunnar C. Hansson
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Cell Reports
Subjects:
CP: Microbiology
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723000955

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http://www.sciencedirect.com/science/article/pii/S2211124723000955

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