SIRT1 ameliorates age-related senescence of mesenchymal stem cells via modulating telomere shelterin

SIRT1 ameliorates age-related senescence of mesenchymal stem cells via modulating telomere shelterin

Age-related mesenchymal stem cells (MSCs) senescence, which impairs its tissue repair capacity in vivo and hence compromises the effects of MSCs-based therapy in clinical applications, is closely related to aging and aging-related diseases. Here, we demonstrated the effect of SIRT1, a NAD+-dependent...

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Bibliographic Details
Main Authors: Huiqiang eChen, Xianbao eLiu, Wei eZhu, Han eChen, Xinyang eHu, Zhi eJiang, Yinchuan eXu, Lihan eWang, Yu eZhou, Panpan eChen, Na eZhang, Dexing eHu, Ling eZhang, Yaping eWang, Qiyuan eXu, Rongrong eWu, Hong eYu, Jian-an eWang
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Aging Neuroscience
Subjects:
Aging
Mesenchymal Stem Cells
Telomerase
senescence
SIRT1
Shelterin
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00103/full

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