ELF5: A Molecular Clock for Breast Aging and Cancer Susceptibility
Breast cancer is predominantly an age-related disease, with aging serving as the most significant risk factor, compounded by germline mutations in high-risk genes like <i>BRCA1</i>/<i>2</i>. Aging induces architectural changes in breast tissue, particularly affecting luminal...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-01-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/16/2/431 |
| _version_ | 1797344438568091648 |
|---|---|
| author | Masaru Miyano Mark A. LaBarge |
| author_facet | Masaru Miyano Mark A. LaBarge |
| author_sort | Masaru Miyano |
| collection | DOAJ |
| description | Breast cancer is predominantly an age-related disease, with aging serving as the most significant risk factor, compounded by germline mutations in high-risk genes like <i>BRCA1</i>/<i>2</i>. Aging induces architectural changes in breast tissue, particularly affecting luminal epithelial cells by diminishing lineage-specific molecular profiles and adopting myoepithelial-like characteristics. ELF5 is an important transcription factor for both normal breast and breast cancer development. This review focuses on the role of ELF5 in normal breast development, its altered expression throughout aging, and its implications in cancer. It discusses the lineage-specific expression of ELF5, its regulatory mechanisms, and its potential as a biomarker for breast-specific biological age and cancer risk. |
| first_indexed | 2024-03-08T11:02:24Z |
| format | Article |
| id | doaj.art-a96269118cd943e582ca2ccfdfc4d94d |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-08T11:02:24Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-a96269118cd943e582ca2ccfdfc4d94d2024-01-26T15:38:31ZengMDPI AGCancers2072-66942024-01-0116243110.3390/cancers16020431ELF5: A Molecular Clock for Breast Aging and Cancer SusceptibilityMasaru Miyano0Mark A. LaBarge1Department of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA 91010, USADepartment of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA 91010, USABreast cancer is predominantly an age-related disease, with aging serving as the most significant risk factor, compounded by germline mutations in high-risk genes like <i>BRCA1</i>/<i>2</i>. Aging induces architectural changes in breast tissue, particularly affecting luminal epithelial cells by diminishing lineage-specific molecular profiles and adopting myoepithelial-like characteristics. ELF5 is an important transcription factor for both normal breast and breast cancer development. This review focuses on the role of ELF5 in normal breast development, its altered expression throughout aging, and its implications in cancer. It discusses the lineage-specific expression of ELF5, its regulatory mechanisms, and its potential as a biomarker for breast-specific biological age and cancer risk.https://www.mdpi.com/2072-6694/16/2/431ELF5mammary epitheliaagingbreast cancerbreast-specific biomarkerearly detection biomarker |
| spellingShingle | Masaru Miyano Mark A. LaBarge ELF5: A Molecular Clock for Breast Aging and Cancer Susceptibility Cancers ELF5 mammary epithelia aging breast cancer breast-specific biomarker early detection biomarker |
| title | ELF5: A Molecular Clock for Breast Aging and Cancer Susceptibility |
| title_full | ELF5: A Molecular Clock for Breast Aging and Cancer Susceptibility |
| title_fullStr | ELF5: A Molecular Clock for Breast Aging and Cancer Susceptibility |
| title_full_unstemmed | ELF5: A Molecular Clock for Breast Aging and Cancer Susceptibility |
| title_short | ELF5: A Molecular Clock for Breast Aging and Cancer Susceptibility |
| title_sort | elf5 a molecular clock for breast aging and cancer susceptibility |
| topic | ELF5 mammary epithelia aging breast cancer breast-specific biomarker early detection biomarker |
| url | https://www.mdpi.com/2072-6694/16/2/431 |
| work_keys_str_mv | AT masarumiyano elf5amolecularclockforbreastagingandcancersusceptibility AT markalabarge elf5amolecularclockforbreastagingandcancersusceptibility |