Personalized alpha-tACS targeting left posterior parietal cortex modulates visuo-spatial attention and posterior evoked EEG activity
Background: Covert visuo-spatial attention is marked by the anticipatory lateralization of neuronal alpha activity in the posterior parietal cortex. Previous applications of transcranial alternating current stimulation (tACS) at the alpha frequency, however, were inconclusive regarding the causal co...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-07-01
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| Series: | Brain Stimulation |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1935861X23018090 |
| _version_ | 1797738000170352640 |
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| author | Jan-Ole Radecke Marina Fiene Jonas Misselhorn Christoph S. Herrmann Andreas K. Engel Carsten H. Wolters Till R. Schneider |
| author_facet | Jan-Ole Radecke Marina Fiene Jonas Misselhorn Christoph S. Herrmann Andreas K. Engel Carsten H. Wolters Till R. Schneider |
| author_sort | Jan-Ole Radecke |
| collection | DOAJ |
| description | Background: Covert visuo-spatial attention is marked by the anticipatory lateralization of neuronal alpha activity in the posterior parietal cortex. Previous applications of transcranial alternating current stimulation (tACS) at the alpha frequency, however, were inconclusive regarding the causal contribution of oscillatory activity during visuo-spatial attention. Objective: Attentional shifts of behavior and electroencephalography (EEG) after-effects were assessed in a cued visuo-spatial attention paradigm. We hypothesized that parietal alpha-tACS shifts attention relative to the ipsilateral visual hemifield. Furthermore, we assumed that modulations of behavior and neurophysiology are related to individual electric field simulations. Methods: We applied personalized tACS at alpha and gamma frequencies to elucidate the role of oscillatory neuronal activity for visuo-spatial attention. Personalized tACS montages were algorithmically optimized to target individual left and right parietal regions that were defined by an EEG localizer. Results: Behavioral performance in the left hemifield was specifically increased by alpha-tACS compared to gamma-tACS targeting the left parietal cortex. This hemisphere-specific effect was observed despite the symmetry of simulated electric fields. In addition, visual event-related potential (ERP) amplitudes showed a reduced lateralization over posterior sites induced by left alpha-tACS. Neuronal sources of this effect were localized in the left premotor cortex. Interestingly, accuracy modulations induced by left parietal alpha-tACS were directly related to electric field magnitudes in the left premotor cortex. Conclusion: Overall, results corroborate the notion that alpha lateralization plays a causal role in covert visuo-spatial attention and indicate an increased susceptibility of parietal and premotor brain regions of the left dorsal attention network to subtle tACS-neuromodulation. |
| first_indexed | 2024-03-12T13:36:35Z |
| format | Article |
| id | doaj.art-a962b50c452a46a8a708e9e5589ec28a |
| institution | Directory Open Access Journal |
| issn | 1935-861X |
| language | English |
| last_indexed | 2024-03-12T13:36:35Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Stimulation |
| spelling | doaj.art-a962b50c452a46a8a708e9e5589ec28a2023-08-24T04:34:47ZengElsevierBrain Stimulation1935-861X2023-07-0116410471061Personalized alpha-tACS targeting left posterior parietal cortex modulates visuo-spatial attention and posterior evoked EEG activityJan-Ole Radecke0Marina Fiene1Jonas Misselhorn2Christoph S. Herrmann3Andreas K. Engel4Carsten H. Wolters5Till R. Schneider6Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany; Corresponding author. Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20251, Hamburg, Germany.Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, GermanyDepartment of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, GermanyExperimental Psychology Lab, Department of Psychology, University of Oldenburg, 26111, Oldenburg, Germany; Research Center Neurosensory Science, University of Oldenburg, 26111, Oldenburg, Germany; Cluster of Excellence “Hearing4all'', GermanyDepartment of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, GermanyInstitute for Biomagnetism and Biosignalanalysis, University of Münster, 48149, Münster, Germany; Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of Münster, 48149, Münster, GermanyDepartment of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, GermanyBackground: Covert visuo-spatial attention is marked by the anticipatory lateralization of neuronal alpha activity in the posterior parietal cortex. Previous applications of transcranial alternating current stimulation (tACS) at the alpha frequency, however, were inconclusive regarding the causal contribution of oscillatory activity during visuo-spatial attention. Objective: Attentional shifts of behavior and electroencephalography (EEG) after-effects were assessed in a cued visuo-spatial attention paradigm. We hypothesized that parietal alpha-tACS shifts attention relative to the ipsilateral visual hemifield. Furthermore, we assumed that modulations of behavior and neurophysiology are related to individual electric field simulations. Methods: We applied personalized tACS at alpha and gamma frequencies to elucidate the role of oscillatory neuronal activity for visuo-spatial attention. Personalized tACS montages were algorithmically optimized to target individual left and right parietal regions that were defined by an EEG localizer. Results: Behavioral performance in the left hemifield was specifically increased by alpha-tACS compared to gamma-tACS targeting the left parietal cortex. This hemisphere-specific effect was observed despite the symmetry of simulated electric fields. In addition, visual event-related potential (ERP) amplitudes showed a reduced lateralization over posterior sites induced by left alpha-tACS. Neuronal sources of this effect were localized in the left premotor cortex. Interestingly, accuracy modulations induced by left parietal alpha-tACS were directly related to electric field magnitudes in the left premotor cortex. Conclusion: Overall, results corroborate the notion that alpha lateralization plays a causal role in covert visuo-spatial attention and indicate an increased susceptibility of parietal and premotor brain regions of the left dorsal attention network to subtle tACS-neuromodulation.http://www.sciencedirect.com/science/article/pii/S1935861X23018090Visuo-spatial attentionElectroencephalographyPersonalized tESNon-invasive brain stimulationFinite element methodElectric field simulation |
| spellingShingle | Jan-Ole Radecke Marina Fiene Jonas Misselhorn Christoph S. Herrmann Andreas K. Engel Carsten H. Wolters Till R. Schneider Personalized alpha-tACS targeting left posterior parietal cortex modulates visuo-spatial attention and posterior evoked EEG activity Brain Stimulation Visuo-spatial attention Electroencephalography Personalized tES Non-invasive brain stimulation Finite element method Electric field simulation |
| title | Personalized alpha-tACS targeting left posterior parietal cortex modulates visuo-spatial attention and posterior evoked EEG activity |
| title_full | Personalized alpha-tACS targeting left posterior parietal cortex modulates visuo-spatial attention and posterior evoked EEG activity |
| title_fullStr | Personalized alpha-tACS targeting left posterior parietal cortex modulates visuo-spatial attention and posterior evoked EEG activity |
| title_full_unstemmed | Personalized alpha-tACS targeting left posterior parietal cortex modulates visuo-spatial attention and posterior evoked EEG activity |
| title_short | Personalized alpha-tACS targeting left posterior parietal cortex modulates visuo-spatial attention and posterior evoked EEG activity |
| title_sort | personalized alpha tacs targeting left posterior parietal cortex modulates visuo spatial attention and posterior evoked eeg activity |
| topic | Visuo-spatial attention Electroencephalography Personalized tES Non-invasive brain stimulation Finite element method Electric field simulation |
| url | http://www.sciencedirect.com/science/article/pii/S1935861X23018090 |
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