Protective effects against tumors and infection by interleukin-27 through promotion of expansion and differentiation of hematopoietic stem cells into myeloid progenitors
Interleukin (IL)-27 is a multifunctional cytokine that belongs to the IL-6/IL-12 family and has potent antitumor activity through various mechanisms. Our novel findings indicate that IL-27 directly acts on hematopoietic stem cells and promotes their expansion and differentiation into myeloid progeni...
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Bibliographic Details
| Main Authors: |
Naoko Orii,
Izuru Mizoguchi,
Yukino Chiba,
Hideaki Hasegawa,
Mio Ohashi,
Mingli Xu,
Taro Nagai,
Nakaba Ochiai,
Yuki Mochizuki,
Toshiyuki Owaki,
Takayuki Yoshimoto |
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| Format: | Article
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| Language: | English |
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| Published: |
Taylor & Francis Group
2018-05-01
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| Series: | OncoImmunology
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| Subjects: | |
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| Online Access: | http://dx.doi.org/10.1080/2162402X.2017.1421892
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