Protective effects against tumors and infection by interleukin-27 through promotion of expansion and differentiation of hematopoietic stem cells into myeloid progenitors
Interleukin (IL)-27 is a multifunctional cytokine that belongs to the IL-6/IL-12 family and has potent antitumor activity through various mechanisms. Our novel findings indicate that IL-27 directly acts on hematopoietic stem cells and promotes their expansion and differentiation into myeloid progeni...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2018-05-01
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| Series: | OncoImmunology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/2162402X.2017.1421892 |
| _version_ | 1818495018461036544 |
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| author | Naoko Orii Izuru Mizoguchi Yukino Chiba Hideaki Hasegawa Mio Ohashi Mingli Xu Taro Nagai Nakaba Ochiai Yuki Mochizuki Toshiyuki Owaki Takayuki Yoshimoto |
| author_facet | Naoko Orii Izuru Mizoguchi Yukino Chiba Hideaki Hasegawa Mio Ohashi Mingli Xu Taro Nagai Nakaba Ochiai Yuki Mochizuki Toshiyuki Owaki Takayuki Yoshimoto |
| author_sort | Naoko Orii |
| collection | DOAJ |
| description | Interleukin (IL)-27 is a multifunctional cytokine that belongs to the IL-6/IL-12 family and has potent antitumor activity through various mechanisms. Our novel findings indicate that IL-27 directly acts on hematopoietic stem cells and promotes their expansion and differentiation into myeloid progenitors to control infection and to eradicate tumors. |
| first_indexed | 2024-12-10T18:14:37Z |
| format | Article |
| id | doaj.art-a964effe11f54bc38921a60a6811dbcc |
| institution | Directory Open Access Journal |
| issn | 2162-402X |
| language | English |
| last_indexed | 2024-12-10T18:14:37Z |
| publishDate | 2018-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | OncoImmunology |
| spelling | doaj.art-a964effe11f54bc38921a60a6811dbcc2022-12-22T01:38:22ZengTaylor & Francis GroupOncoImmunology2162-402X2018-05-017510.1080/2162402X.2017.14218921421892Protective effects against tumors and infection by interleukin-27 through promotion of expansion and differentiation of hematopoietic stem cells into myeloid progenitorsNaoko Orii0Izuru Mizoguchi1Yukino Chiba2Hideaki Hasegawa3Mio Ohashi4Mingli Xu5Taro Nagai6Nakaba Ochiai7Yuki Mochizuki8Toshiyuki Owaki9Takayuki Yoshimoto10Institute of Medical Science, Tokyo Medical UniversityInstitute of Medical Science, Tokyo Medical UniversityInstitute of Medical Science, Tokyo Medical UniversityInstitute of Medical Science, Tokyo Medical UniversityInstitute of Medical Science, Tokyo Medical UniversityInstitute of Medical Science, Tokyo Medical UniversityTokyo Medical UniversityInstitute of Medical Science, Tokyo Medical UniversityInstitute of Medical Science, Tokyo Medical UniversityInstitute of Medical Science, Tokyo Medical UniversityInstitute of Medical Science, Tokyo Medical UniversityInterleukin (IL)-27 is a multifunctional cytokine that belongs to the IL-6/IL-12 family and has potent antitumor activity through various mechanisms. Our novel findings indicate that IL-27 directly acts on hematopoietic stem cells and promotes their expansion and differentiation into myeloid progenitors to control infection and to eradicate tumors.http://dx.doi.org/10.1080/2162402X.2017.1421892il-27hematopoietic stem cellsmyeloid progenitorsemergency myelopoiesisantitumor activity |
| spellingShingle | Naoko Orii Izuru Mizoguchi Yukino Chiba Hideaki Hasegawa Mio Ohashi Mingli Xu Taro Nagai Nakaba Ochiai Yuki Mochizuki Toshiyuki Owaki Takayuki Yoshimoto Protective effects against tumors and infection by interleukin-27 through promotion of expansion and differentiation of hematopoietic stem cells into myeloid progenitors OncoImmunology il-27 hematopoietic stem cells myeloid progenitors emergency myelopoiesis antitumor activity |
| title | Protective effects against tumors and infection by interleukin-27 through promotion of expansion and differentiation of hematopoietic stem cells into myeloid progenitors |
| title_full | Protective effects against tumors and infection by interleukin-27 through promotion of expansion and differentiation of hematopoietic stem cells into myeloid progenitors |
| title_fullStr | Protective effects against tumors and infection by interleukin-27 through promotion of expansion and differentiation of hematopoietic stem cells into myeloid progenitors |
| title_full_unstemmed | Protective effects against tumors and infection by interleukin-27 through promotion of expansion and differentiation of hematopoietic stem cells into myeloid progenitors |
| title_short | Protective effects against tumors and infection by interleukin-27 through promotion of expansion and differentiation of hematopoietic stem cells into myeloid progenitors |
| title_sort | protective effects against tumors and infection by interleukin 27 through promotion of expansion and differentiation of hematopoietic stem cells into myeloid progenitors |
| topic | il-27 hematopoietic stem cells myeloid progenitors emergency myelopoiesis antitumor activity |
| url | http://dx.doi.org/10.1080/2162402X.2017.1421892 |
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