Enhancement of a prime editing system via optimal recruitment of the pioneer transcription factor P65
Prime editing represents a great advance to the genome editing field but is currently limited by the editing efficiency. Here the authors look to improve the efficiency by recruiting target proteins and show that the transcription factor P65 could enhance the desired editing outcomes at different ge...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-35919-0 |
| _version_ | 1811177022449254400 |
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| author | Ronghao Chen Yu Cao Yajing Liu Dongdong Zhao Ju Li Zhihui Cheng Changhao Bi Xueli Zhang |
| author_facet | Ronghao Chen Yu Cao Yajing Liu Dongdong Zhao Ju Li Zhihui Cheng Changhao Bi Xueli Zhang |
| author_sort | Ronghao Chen |
| collection | DOAJ |
| description | Prime editing represents a great advance to the genome editing field but is currently limited by the editing efficiency. Here the authors look to improve the efficiency by recruiting target proteins and show that the transcription factor P65 could enhance the desired editing outcomes at different gene loci. |
| first_indexed | 2024-04-10T21:01:14Z |
| format | Article |
| id | doaj.art-a9653fd8e62547feadfa9b23d852884b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-10T21:01:14Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a9653fd8e62547feadfa9b23d852884b2023-01-22T12:18:18ZengNature PortfolioNature Communications2041-17232023-01-011411810.1038/s41467-023-35919-0Enhancement of a prime editing system via optimal recruitment of the pioneer transcription factor P65Ronghao Chen0Yu Cao1Yajing Liu2Dongdong Zhao3Ju Li4Zhihui Cheng5Changhao Bi6Xueli Zhang7College of Life Science, Nankai UniversityCollege of Life Science, Nankai UniversityCollege of Life Science, Nankai UniversityTianjin Institute of Industrial Biotechnology, Chinese Academy of SciencesCollege of Life Science, Tianjin Normal UniversityCollege of Life Science, Nankai UniversityTianjin Institute of Industrial Biotechnology, Chinese Academy of SciencesTianjin Institute of Industrial Biotechnology, Chinese Academy of SciencesPrime editing represents a great advance to the genome editing field but is currently limited by the editing efficiency. Here the authors look to improve the efficiency by recruiting target proteins and show that the transcription factor P65 could enhance the desired editing outcomes at different gene loci.https://doi.org/10.1038/s41467-023-35919-0 |
| spellingShingle | Ronghao Chen Yu Cao Yajing Liu Dongdong Zhao Ju Li Zhihui Cheng Changhao Bi Xueli Zhang Enhancement of a prime editing system via optimal recruitment of the pioneer transcription factor P65 Nature Communications |
| title | Enhancement of a prime editing system via optimal recruitment of the pioneer transcription factor P65 |
| title_full | Enhancement of a prime editing system via optimal recruitment of the pioneer transcription factor P65 |
| title_fullStr | Enhancement of a prime editing system via optimal recruitment of the pioneer transcription factor P65 |
| title_full_unstemmed | Enhancement of a prime editing system via optimal recruitment of the pioneer transcription factor P65 |
| title_short | Enhancement of a prime editing system via optimal recruitment of the pioneer transcription factor P65 |
| title_sort | enhancement of a prime editing system via optimal recruitment of the pioneer transcription factor p65 |
| url | https://doi.org/10.1038/s41467-023-35919-0 |
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