Enhancement of a prime editing system via optimal recruitment of the pioneer transcription factor P65
Prime editing represents a great advance to the genome editing field but is currently limited by the editing efficiency. Here the authors look to improve the efficiency by recruiting target proteins and show that the transcription factor P65 could enhance the desired editing outcomes at different ge...
Main Authors: | Ronghao Chen, Yu Cao, Yajing Liu, Dongdong Zhao, Ju Li, Zhihui Cheng, Changhao Bi, Xueli Zhang |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-01-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-023-35919-0 |
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