Insulin receptor tyrosine kinase substrate enhances low levels of MDM2-mediated p53 ubiquitination.

Insulin receptor tyrosine kinase substrate enhances low levels of MDM2-mediated p53 ubiquitination.

The tumor suppressor p53 controls multiple cellular functions including DNA repair, cell cycle arrest and apoptosis. MDM2-mediated p53 ubiquitination affects both degradation and cytoplasmic localization of p53. Several cofactors are known to modulate MDM2-mediated p53 ubiquitination and proteasomal...

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Bibliographic Details
Main Authors: Ke-Sheng Wang, Gang Chen, Hai-Lian Shen, Ting-Ting Li, Fei Chen, Qin-Wan Wang, Zhi-Qin Wang, Ze-Guang Han, Xin Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3160901?pdf=render

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