A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entry
The serine protease TMPRSS2 primes SARS-CoV-2 glycoprotein for cell entry. Here, the authors perform a screen to identify drugs that reduce TMPRSS2 expression and find that halofuginone modulates proteasome-mediated degradation of TMPRSS2 and reduces entry of SARS-CoV-2.
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-24156-y |
| _version_ | 1818839224415158272 |
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| author | Yanwen Chen Travis B. Lear John W. Evankovich Mads B. Larsen Bo Lin Irene Alfaras Jason R. Kennerdell Laura Salminen Daniel P. Camarco Karina C. Lockwood Ferhan Tuncer Jie Liu Michael M. Myerburg John F. McDyer Yuan Liu Toren Finkel Bill B. Chen |
| author_facet | Yanwen Chen Travis B. Lear John W. Evankovich Mads B. Larsen Bo Lin Irene Alfaras Jason R. Kennerdell Laura Salminen Daniel P. Camarco Karina C. Lockwood Ferhan Tuncer Jie Liu Michael M. Myerburg John F. McDyer Yuan Liu Toren Finkel Bill B. Chen |
| author_sort | Yanwen Chen |
| collection | DOAJ |
| description | The serine protease TMPRSS2 primes SARS-CoV-2 glycoprotein for cell entry. Here, the authors perform a screen to identify drugs that reduce TMPRSS2 expression and find that halofuginone modulates proteasome-mediated degradation of TMPRSS2 and reduces entry of SARS-CoV-2. |
| first_indexed | 2024-12-19T03:50:53Z |
| format | Article |
| id | doaj.art-a96a0ab6494b4682a6b6f2fb49128893 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T03:50:53Z |
| publishDate | 2021-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a96a0ab6494b4682a6b6f2fb491288932022-12-21T20:37:00ZengNature PortfolioNature Communications2041-17232021-06-0112111510.1038/s41467-021-24156-yA high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entryYanwen Chen0Travis B. Lear1John W. Evankovich2Mads B. Larsen3Bo Lin4Irene Alfaras5Jason R. Kennerdell6Laura Salminen7Daniel P. Camarco8Karina C. Lockwood9Ferhan Tuncer10Jie Liu11Michael M. Myerburg12John F. McDyer13Yuan Liu14Toren Finkel15Bill B. Chen16Aging Institute, University of Pittsburgh/UPMCAging Institute, University of Pittsburgh/UPMCAging Institute, University of Pittsburgh/UPMCAging Institute, University of Pittsburgh/UPMCAging Institute, University of Pittsburgh/UPMCAging Institute, University of Pittsburgh/UPMCAging Institute, University of Pittsburgh/UPMCAging Institute, University of Pittsburgh/UPMCAging Institute, University of Pittsburgh/UPMCAging Institute, University of Pittsburgh/UPMCAging Institute, University of Pittsburgh/UPMCAging Institute, University of Pittsburgh/UPMCDepartment of Medicine, Acute Lung Injury Center of Excellence, University of PittsburghDepartment of Medicine, Acute Lung Injury Center of Excellence, University of PittsburghAging Institute, University of Pittsburgh/UPMCAging Institute, University of Pittsburgh/UPMCAging Institute, University of Pittsburgh/UPMCThe serine protease TMPRSS2 primes SARS-CoV-2 glycoprotein for cell entry. Here, the authors perform a screen to identify drugs that reduce TMPRSS2 expression and find that halofuginone modulates proteasome-mediated degradation of TMPRSS2 and reduces entry of SARS-CoV-2.https://doi.org/10.1038/s41467-021-24156-y |
| spellingShingle | Yanwen Chen Travis B. Lear John W. Evankovich Mads B. Larsen Bo Lin Irene Alfaras Jason R. Kennerdell Laura Salminen Daniel P. Camarco Karina C. Lockwood Ferhan Tuncer Jie Liu Michael M. Myerburg John F. McDyer Yuan Liu Toren Finkel Bill B. Chen A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entry Nature Communications |
| title | A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entry |
| title_full | A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entry |
| title_fullStr | A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entry |
| title_full_unstemmed | A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entry |
| title_short | A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entry |
| title_sort | high throughput screen for tmprss2 expression identifies fda approved compounds that can limit sars cov 2 entry |
| url | https://doi.org/10.1038/s41467-021-24156-y |
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