Discharge protocol in acute pancreatitis: an international survey and cohort analysis
Abstract There are several overlapping clinical practice guidelines in acute pancreatitis (AP), however, none of them contains suggestions on patient discharge. The Hungarian Pancreatic Study Group (HPSG) has recently developed a laboratory data and symptom-based discharge protocol which needs to be...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-48480-z |
| _version_ | 1827581592289148928 |
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| author | Rita Nagy Klementina Ocskay Zoltán Sipos Andrea Szentesi Áron Vincze László Czakó Ferenc Izbéki Natalia V. Shirinskaya Vladimir L. Poluektov Alexandr N. Zolotov Yin Zhu Liang Xia Wenhua He Robert Sutton Peter Szatmary Rajarshi Mukherjee Isobel Saffron Burridge Emma Wauchope Elsa Francisco David Aparicio Bruno Pinto António Gomes Vitor Nunes Vasile Marcel Tantau Emanuela Denisa Sagau Alina Ioana Tantau Andra Iulia Suceveanu Cristina Tocia Andrei Dumitru Elizabeth Pando Piero Alberti Arturo Cirera Xavier Molero Hong Sik Lee Min Kyu Jung Eui Joo Kim Sanghyub Lee María Lourdes Ruiz Rebollo Reyes Busta Nistal Sandra Izquierdo Santervas Dusan Lesko Marek Soltes Jozef Radonak Hubert Zatorski Ewa Małecka-Panas Adam Fabisiak M. Susak Yaroslav V. Maksymenko Mykhailo A. Tkachenko Olekcandr Giedrius Barauskas Vytautas Simanaitis Povilas Ignatavicius Mariana Jinga Vasile-Daniel Balaban Cristina Patoni Liang Gong Kai Song Yunlong Li T. Cúrdia Gonçalves Marta Freitas Vítor Macedo Marlies Vornhuelz Sarah Klauss Georg Beyer Aydin Seref Koksal Mukaddes Tozlu Ahmet Tarik Eminler Nuria Torres Monclús Eva Pijoan Comas Juan Armando Rodriguez Oballe Łukasz Nawacki Stanisław Głuszek Alberto Rama-Fernández Marco Galego Daniel de la Iglesia Umut Emre Aykut Deniz Güney Duman Rahmi Aslan Adriana Gherbon Lihui Deng Wei Huang Qing Xia Goran Poropat Anja Radovan Luka Vranić Claudio Ricci Carlo Ingaldi Riccardo Casadei Ionut Negoi Cezar Ciubotaru Florin Mihail Iordache Gabriel Constantinescu Vasile Sandru Engin Altintas Hatice Rizaoglu Balci Júlio Constantino Débora Aveiro Jorge Pereira Suleyman Gunay Seda Misirlioglu Sucan Oleksiy Dronov Inna Kovalska Nikhil Bush Surinder Singh Rana Serge Chooklin Serhii Chuklin Ionut Adrian Saizu Cristian Gheorghe Philipp Göltl Michael Hirth Radu Bogdan Mateescu Geanina Papuc Georgi Angelov Minkov Emil Tihomirov Enchev Laura Mastrangelo Elio Jovine Weiwei Chen Quping Zhu Anita Gąsiorowska Natalia Fabisiak Mihailo Bezmarevic Andrey Litvin Martina Cattani Mottes Eun Kwang Choi Peter Bánovčin Lenka Nosáková Mila Dimitrova Kovacheva-Slavova Ali Kchaou Ahmed Tlili Marco V. Marino Katarzyna Kusnierz Artautas Mickevicius Marcus Hollenbach Pavol Molcan Orestis Ioannidis Mark Valerievich Tokarev Ali Tüzün Ince Ivan Albertovich Semenenko Shamil Galeev Elena Ramírez-Maldonado Ville Sallinen Petr Pencik Judit Bajor Patricia Sarlós Roland Hágendorn Szilárd Gódi Imre Szabó József Czimmer Gabriella Pár Anita Illés Nándor Faluhelyi Péter Kanizsai Tamás Nagy Alexandra Mikó Balázs Németh József Hamvas Barnabás Bod Márta Varga Imola Török János Novák Árpád Patai János Sümegi Csaba Góg Mária Papp Bálint Erőss Szilárd Váncsa Brigitta Teutsch Katalin Márta Péter Jenő Hegyi Tamás Tornai Balázs Lázár Tamás Hussein Dorottya Tarján Mónika Lipp Beáta Kovács Orsolya Urbán Emese Fürst Edina Tari Ibolya Kocsis Pál Maurovich-Horvát Balázs Tihanyi Orsolya Eperjesi Zita Kormos Pál Ákos Deák Andrea Párniczky Péter Hegyi |
| author_facet | Rita Nagy Klementina Ocskay Zoltán Sipos Andrea Szentesi Áron Vincze László Czakó Ferenc Izbéki Natalia V. Shirinskaya Vladimir L. Poluektov Alexandr N. Zolotov Yin Zhu Liang Xia Wenhua He Robert Sutton Peter Szatmary Rajarshi Mukherjee Isobel Saffron Burridge Emma Wauchope Elsa Francisco David Aparicio Bruno Pinto António Gomes Vitor Nunes Vasile Marcel Tantau Emanuela Denisa Sagau Alina Ioana Tantau Andra Iulia Suceveanu Cristina Tocia Andrei Dumitru Elizabeth Pando Piero Alberti Arturo Cirera Xavier Molero Hong Sik Lee Min Kyu Jung Eui Joo Kim Sanghyub Lee María Lourdes Ruiz Rebollo Reyes Busta Nistal Sandra Izquierdo Santervas Dusan Lesko Marek Soltes Jozef Radonak Hubert Zatorski Ewa Małecka-Panas Adam Fabisiak M. Susak Yaroslav V. Maksymenko Mykhailo A. Tkachenko Olekcandr Giedrius Barauskas Vytautas Simanaitis Povilas Ignatavicius Mariana Jinga Vasile-Daniel Balaban Cristina Patoni Liang Gong Kai Song Yunlong Li T. Cúrdia Gonçalves Marta Freitas Vítor Macedo Marlies Vornhuelz Sarah Klauss Georg Beyer Aydin Seref Koksal Mukaddes Tozlu Ahmet Tarik Eminler Nuria Torres Monclús Eva Pijoan Comas Juan Armando Rodriguez Oballe Łukasz Nawacki Stanisław Głuszek Alberto Rama-Fernández Marco Galego Daniel de la Iglesia Umut Emre Aykut Deniz Güney Duman Rahmi Aslan Adriana Gherbon Lihui Deng Wei Huang Qing Xia Goran Poropat Anja Radovan Luka Vranić Claudio Ricci Carlo Ingaldi Riccardo Casadei Ionut Negoi Cezar Ciubotaru Florin Mihail Iordache Gabriel Constantinescu Vasile Sandru Engin Altintas Hatice Rizaoglu Balci Júlio Constantino Débora Aveiro Jorge Pereira Suleyman Gunay Seda Misirlioglu Sucan Oleksiy Dronov Inna Kovalska Nikhil Bush Surinder Singh Rana Serge Chooklin Serhii Chuklin Ionut Adrian Saizu Cristian Gheorghe Philipp Göltl Michael Hirth Radu Bogdan Mateescu Geanina Papuc Georgi Angelov Minkov Emil Tihomirov Enchev Laura Mastrangelo Elio Jovine Weiwei Chen Quping Zhu Anita Gąsiorowska Natalia Fabisiak Mihailo Bezmarevic Andrey Litvin Martina Cattani Mottes Eun Kwang Choi Peter Bánovčin Lenka Nosáková Mila Dimitrova Kovacheva-Slavova Ali Kchaou Ahmed Tlili Marco V. Marino Katarzyna Kusnierz Artautas Mickevicius Marcus Hollenbach Pavol Molcan Orestis Ioannidis Mark Valerievich Tokarev Ali Tüzün Ince Ivan Albertovich Semenenko Shamil Galeev Elena Ramírez-Maldonado Ville Sallinen Petr Pencik Judit Bajor Patricia Sarlós Roland Hágendorn Szilárd Gódi Imre Szabó József Czimmer Gabriella Pár Anita Illés Nándor Faluhelyi Péter Kanizsai Tamás Nagy Alexandra Mikó Balázs Németh József Hamvas Barnabás Bod Márta Varga Imola Török János Novák Árpád Patai János Sümegi Csaba Góg Mária Papp Bálint Erőss Szilárd Váncsa Brigitta Teutsch Katalin Márta Péter Jenő Hegyi Tamás Tornai Balázs Lázár Tamás Hussein Dorottya Tarján Mónika Lipp Beáta Kovács Orsolya Urbán Emese Fürst Edina Tari Ibolya Kocsis Pál Maurovich-Horvát Balázs Tihanyi Orsolya Eperjesi Zita Kormos Pál Ákos Deák Andrea Párniczky Péter Hegyi |
| author_sort | Rita Nagy |
| collection | DOAJ |
| description | Abstract There are several overlapping clinical practice guidelines in acute pancreatitis (AP), however, none of them contains suggestions on patient discharge. The Hungarian Pancreatic Study Group (HPSG) has recently developed a laboratory data and symptom-based discharge protocol which needs to be validated. (1) A survey was conducted involving all members of the International Association of Pancreatology (IAP) to understand the characteristics of international discharge protocols. (2) We investigated the safety and effectiveness of the HPSG-discharge protocol. According to our international survey, 87.5% (49/56) of the centres had no discharge protocol. Patients discharged based on protocols have a significantly shorter median length of hospitalization (LOH) (7 (5;10) days vs. 8 (5;12) days) p < 0.001), and a lower rate of readmission due to recurrent AP episodes (p = 0.005). There was no difference in median discharge CRP level among the international cohorts (p = 0.586). HPSG-protocol resulted in the shortest LOH (6 (5;9) days) and highest median CRP (35.40 (13.78; 68.40) mg/l). Safety was confirmed by the low rate of readmittance (n = 35; 5%). Discharge protocol is necessary in AP. The discharge protocol used in this study is the first clinically proven protocol. Developing and testifying further protocols are needed to better standardize patients’ care. |
| first_indexed | 2024-03-08T22:38:37Z |
| format | Article |
| id | doaj.art-a96a78ca9d3d48939bfd1f29c8bb783a |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-08T22:38:37Z |
| publishDate | 2023-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-a96a78ca9d3d48939bfd1f29c8bb783a2023-12-17T12:18:19ZengNature PortfolioScientific Reports2045-23222023-12-0113111010.1038/s41598-023-48480-zDischarge protocol in acute pancreatitis: an international survey and cohort analysisRita Nagy0Klementina Ocskay1Zoltán Sipos2Andrea Szentesi3Áron Vincze4László Czakó5Ferenc Izbéki6Natalia V. Shirinskaya7Vladimir L. Poluektov8Alexandr N. Zolotov9Yin Zhu10Liang Xia11Wenhua He12Robert Sutton13Peter Szatmary14Rajarshi Mukherjee15Isobel Saffron Burridge16Emma Wauchope17Elsa Francisco18David Aparicio19Bruno Pinto20António Gomes21Vitor Nunes22Vasile Marcel Tantau23Emanuela Denisa Sagau24Alina Ioana Tantau25Andra Iulia Suceveanu26Cristina Tocia27Andrei Dumitru28Elizabeth Pando29Piero Alberti30Arturo Cirera31Xavier Molero32Hong Sik Lee33Min Kyu Jung34Eui Joo Kim35Sanghyub Lee36María Lourdes Ruiz Rebollo37Reyes Busta Nistal38Sandra Izquierdo Santervas39Dusan Lesko40Marek Soltes41Jozef Radonak42Hubert Zatorski43Ewa Małecka-Panas44Adam Fabisiak45M. Susak Yaroslav46V. Maksymenko Mykhailo47A. Tkachenko Olekcandr48Giedrius Barauskas49Vytautas Simanaitis50Povilas Ignatavicius51Mariana Jinga52Vasile-Daniel Balaban53Cristina Patoni54Liang Gong55Kai Song56Yunlong Li57T. Cúrdia Gonçalves58Marta Freitas59Vítor Macedo60Marlies Vornhuelz61Sarah Klauss62Georg Beyer63Aydin Seref Koksal64Mukaddes Tozlu65Ahmet Tarik Eminler66Nuria Torres Monclús67Eva Pijoan Comas68Juan Armando Rodriguez Oballe69Łukasz Nawacki70Stanisław Głuszek71Alberto Rama-Fernández72Marco Galego73Daniel de la Iglesia74Umut Emre Aykut75Deniz Güney Duman76Rahmi Aslan77Adriana Gherbon78Lihui Deng79Wei Huang80Qing Xia81Goran Poropat82Anja Radovan83Luka Vranić84Claudio Ricci85Carlo Ingaldi86Riccardo Casadei87Ionut Negoi88Cezar Ciubotaru89Florin Mihail Iordache90Gabriel Constantinescu91Vasile Sandru92Engin Altintas93Hatice Rizaoglu Balci94Júlio Constantino95Débora Aveiro96Jorge Pereira97Suleyman Gunay98Seda Misirlioglu Sucan99Oleksiy Dronov100Inna Kovalska101Nikhil Bush102Surinder Singh Rana103Serge Chooklin104Serhii Chuklin105Ionut Adrian Saizu106Cristian Gheorghe107Philipp Göltl108Michael Hirth109Radu Bogdan Mateescu110Geanina Papuc111Georgi Angelov Minkov112Emil Tihomirov Enchev113Laura Mastrangelo114Elio Jovine115Weiwei Chen116Quping Zhu117Anita Gąsiorowska118Natalia Fabisiak119Mihailo Bezmarevic120Andrey Litvin121Martina Cattani Mottes122Eun Kwang Choi123Peter Bánovčin124Lenka Nosáková125Mila Dimitrova Kovacheva-Slavova126Ali Kchaou127Ahmed Tlili128Marco V. Marino129Katarzyna Kusnierz130Artautas Mickevicius131Marcus Hollenbach132Pavol Molcan133Orestis Ioannidis134Mark Valerievich Tokarev135Ali Tüzün Ince136Ivan Albertovich Semenenko137Shamil Galeev138Elena Ramírez-Maldonado139Ville Sallinen140Petr Pencik141Judit Bajor142Patricia Sarlós143Roland Hágendorn144Szilárd Gódi145Imre Szabó146József Czimmer147Gabriella Pár148Anita Illés149Nándor Faluhelyi150Péter Kanizsai151Tamás Nagy152Alexandra Mikó153Balázs Németh154József Hamvas155Barnabás Bod156Márta Varga157Imola Török158János Novák159Árpád Patai160János Sümegi161Csaba Góg162Mária Papp163Bálint Erőss164Szilárd Váncsa165Brigitta Teutsch166Katalin Márta167Péter Jenő Hegyi168Tamás Tornai169Balázs Lázár170Tamás Hussein171Dorottya Tarján172Mónika Lipp173Beáta Kovács174Orsolya Urbán175Emese Fürst176Edina Tari177Ibolya Kocsis178Pál Maurovich-Horvát179Balázs Tihanyi180Orsolya Eperjesi181Zita Kormos182Pál Ákos Deák183Andrea Párniczky184Péter Hegyi185Centre for Translational Medicine, Semmelweis UniversityHeim Pál National Pediatric InstituteInstitute for Translational Medicine, Medical School, University of PécsInstitute for Translational Medicine, Medical School, University of PécsDivision of Gastroenterology, First Department of Medicine, Medical School, University of PécsDepartment of Medicine, University of SzegedSzent György University Teaching Hospital of Fejér CountyOmsk State Medical Information-Analytical Centre, Omsk State Medical UniversityDepartment of Surgery and Urology, Omsk State Medical UniversityDepartment of Pathophysiology, Clinical Pathophysiology, Omsk State Medical UniversityDepartment of Gastroenterology, First Affiliated Hospital of Nanchang UniversityDepartment of Gastroenterology, First Affiliated Hospital of Nanchang UniversityDepartment of Gastroenterology, First Affiliated Hospital of Nanchang UniversityUniversity of Liverpool, Liverpool University Hospitals NHS Foundation TrustUniversity of Liverpool, Liverpool University Hospitals NHS Foundation TrustUniversity of Liverpool, Liverpool University Hospitals NHS Foundation TrustLiverpool University Hospitals NHS Foundation TrustLiverpool University Hospitals NHS Foundation TrustSurgery Department, Hospital Prof. Ferndo FonsecaSurgery Department, Hospital Prof. Ferndo FonsecaSurgery Department, Hospital Prof. Ferndo FonsecaSurgery Department, Hospital Prof. Ferndo FonsecaSurgery Department, Hospital Prof. Ferndo Fonseca“Octavin Fodor” Institute of Gastroenterology and Hepartology, “Iuliu Hatieganu” University of Medicine and Pharmacy“Octavin Fodor” Institute of Gastroenterology and Hepartology, “Iuliu Hatieganu” University of Medicine and PharmacyGastroenterology Department, 4th Medical Clinic, “Iuliu Hatieganu” University of Medicine and PharmacyFaculty of Medicine, Ovidius University of ConstantaFaculty of Medicine, Ovidius University of ConstantaFaculty of Medicine, Ovidius University of ConstantaDepartment of Hepato-Pancreato-Biliary and Transplant Surgery, Hospital Universitari Vall d’Hebron, Universitat Autònoma de BarcelonaDepartment of Hepato-Pancreato-Biliary and Transplant Surgery, Hospital Universitari Vall d’Hebron, Universitat Autònoma de BarcelonaDepartment of Hepato-Pancreato-Biliary and Transplant Surgery, Hospital Universitari Vall d’Hebron, Universitat Autònoma de BarcelonaExocrine Pancreas Research Unit, Hospital Universitari Vall d’Hebron, Institut de Recerca, Universitat Autònoma de Barcelona, CIBEREHDDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University Anam HospitalDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University Anam HospitalDivision of Gastroenterology, Department of Internal Medicine, Gachon University Gil Medical Center, Gachon University College of MedicineDepartment of Internal Medicine and Liver Research Institute, Seoul National University HospitalServicio de Aparato Digestivo Hospital Clínico Universitario ValladolidServicio de Aparato Digestivo Hospital Clínico Universitario ValladolidServicio de Aparato Digestivo Hospital Clínico Universitario Valladolid1st Department of Surgery, University Hospital of L. Pasteur1st Department of Surgery, University Hospital of L. Pasteur1st Department of Surgery, University Hospital of L. PasteurDepartment of Digestive Tract Diseases, Medical University of LodzDepartment of Digestive Tract Diseases, Medical University of LodzDepartment of Digestive Tract Diseases, Medical University of LodzDepartment of Surgery With a Course of Emergency and Vascular Surgery, Bogomolet National Medical UniversityDepartment of Surgery With a Course of Emergency and Vascular Surgery, Bogomolet National Medical UniversityKyiv City Clinical Emergency HospitalDepartment of Surgery, Lithuanian University of Health SciencesDepartment of Surgery, Lithuanian University of Health SciencesKyiv City Clinical Emergency HospitalDepartment of Surgery, Lithuanian University of Health SciencesDepartment of Surgery, Lithuanian University of Health Sciences“Carol Davila” University of Medicine and Pharmacy“Carol Davila” University of Medicine and Pharmacy“Carol Davila” University of Medicine and Pharmacy“Carol Davila” University of Medicine and PharmacyGastroenterology Department, Hospital da Senhora da OliveiraDepartment of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical CollegeDepartment of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical CollegeLMU University Hospital, LMU MunichLMU University Hospital, LMU MunichLMU University Hospital, LMU MunichDepartment of Gastroenterology, Faculty of Medicine, Sakarya UniversityDepartment of Gastroenterology, Faculty of Medicine, Sakarya UniversityDepartment of Gastroenterology, Faculty of Medicine, Sakarya UniversityUniversity Hospital Arnau de Vilanova, Hospital University Santa MariaUniversity Hospital Arnau de Vilanova, Hospital University Santa MariaUniversity Hospital Arnau de Vilanova, Hospital University Santa MariaCollegium Medicum, The Jan Kochanowski University in KielceCollegium Medicum, The Jan Kochanowski University in KielceGastroenterology Department, University Hospital of Santiago de CompostelaGastroenterology Department, University Hospital of Santiago de CompostelaGastroenterology Department, University Hospital of Santiago de CompostelaMarmara University Education and Training HospitalMarmara University Education and Training HospitalMarmara University Education and Training HospitalDiscipline of Internal Medicine: Diabetes, Nutrition, Metabolic Diseases and Systemic Rheumatology, Victor Babeş University of Medicine and Pharmacy TimisoaraDepartment of Integrated Traditional Chinese and Western Medicine, Sichuan Provincial Pancreatitis Center and West China-Liverpool Biomedical Research Center, West China Hospital, Sichuan UniversityDepartment of Integrated Traditional Chinese and Western Medicine, Sichuan Provincial Pancreatitis Center and West China-Liverpool Biomedical Research Center, West China Hospital, Sichuan UniversityDepartment of Integrated Traditional Chinese and Western Medicine, Sichuan Provincial Pancreatitis Center and West China-Liverpool Biomedical Research Center, West China Hospital, Sichuan UniversityDepartment of Gastroenterology, Clinical Hospital Center Rijeka, University of RijekaDepartment of Gastroenterology, Clinical Hospital Center Rijeka, University of RijekaDepartment of Gastroenterology, Clinical Hospital Center Rijeka, University of RijekaDivision of Pancreatic Surgery, IRCCS, Azienda Ospedaliero Universitaria di BolognaDivision of Pancreatic Surgery, IRCCS, Azienda Ospedaliero Universitaria di BolognaDivision of Pancreatic Surgery, IRCCS, Azienda Ospedaliero Universitaria di BolognaEmergency Hospital of Bucharest, Carol Davila University of Medicine and Pharmacy BucharestEmergency Hospital of Bucharest, Carol Davila University of Medicine and Pharmacy BucharestEmergency Hospital of Bucharest, Carol Davila University of Medicine and Pharmacy BucharestEmergency Hospital of Bucharest, Carol Davila University of Medicine and Pharmacy BucharestEmergency Hospital of Bucharest, Carol Davila University of Medicine and Pharmacy BucharestGastroenterology Department, Faculty of Medicine, Mersin UniversityGastroenterology Department, Faculty of Medicine, Mersin UniversityUnidade HBP, Serviço de Cirurgia Geral, Centro Hospitalar Tondela-ViseuUnidade HBP, Serviço de Cirurgia Geral, Centro Hospitalar Tondela-ViseuUnidade HBP, Serviço de Cirurgia Geral, Centro Hospitalar Tondela-Viseuİzmir Katip Çelebi University Atatürk Training and Research Hospitalİzmir Katip Çelebi University Atatürk Training and Research HospitalGeneral Surgery #1, Bogomolets National Medical UniversityGeneral Surgery #1, Bogomolets National Medical UniversityDepartment of Gastroenterology, Postgraduate Institute of Medical Education and Research (PGIMER)Department of Gastroenterology, Postgraduate Institute of Medical Education and Research (PGIMER)Lviv Regional Clinical HospitalLviv Regional Clinical HospitalClinical Institute Fundeni“Carol Davila” University of Medicine and PharmacyDepartment of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg UniversityDepartment of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University“Carol Davila” University of Medicine and PharmacyGastroenterology Department, Colentina Clinical Hospital BucharestDepartment of Surgery, University HospitalDepartment of Surgery, University HospitalDepartment of Surgery, AOU Sant’Orsola Malpighi, IRCCS Azienda Ospedaliera UniversitariaDepartment of Surgery, AOU Sant’Orsola Malpighi, IRCCS Azienda Ospedaliera UniversitariaDepartment of Gastroenterology, Clinical Medical College, Yangzhou UniversityDepartment of Gastroenterology, Clinical Medical College, Yangzhou UniversityDepartment of Gastroenterology Medical, University of LodzDepartment of Gastroenterology Medical, University of LodzDepartment for Hepatobiliary and Pancreatic Surgery, Clinic for General Surgery, Military Medical Academy, University of DefenseGomel State Medical UniversityDepartment of Medicine, Gastroenterology, The Pancreas Institute, G.B. Rossi University HospitalDepartment of Internal Medicine, Jeju National University College of MedicineClinic of Internal Medicine - Gastroenterology, JFM CU, Jessenius Faculty of Medicine in Martin (JFM CU), Comenius University in BratislavaClinic of Internal Medicine - Gastroenterology, JFM CU, Jessenius Faculty of Medicine in Martin (JFM CU), Comenius University in BratislavaDepartment of Gastroenterology, Queen Yoanna University Hospital, Medical University of SofiaHabib Bourguiba University HospitalMohamed Ben Sassi HospitalGeneral Surgery Department, Azienda Ospedaliera Ospedali Riuniti Villa Sofia-CervelloVilnius University Hospital Santariskiu KlinikosVilnius University Hospital Santariskiu KlinikosDivision of Gastroenterology, University of Leipzig Medical CenterHepatology and Gastroenterology Department of Roosevelt Hospital4th Department of Surgery, Medical School, Aristotle University of Thessaloniki, General Hospital “George Papanikolaou”Sklifosovsky Institute for Clinical Medicine, Sechenov First Moscow State Medical UniversityHospital of Bezmialem Vakif University, School of MedicineSechenov UniversitySaint Luke Clinical HospitalGeneral Surgery, Consorci Sanitari del Garraf, Sant Pere de RibesDepartment of Transplantation and Liver Surgery, Helsinki University Hospital and University of HelsinkiCentrum péče o zažívací trakt, Vítkovická Nemocnice a.s.Division of Gastroenterology, First Department of Medicine, Medical School, University of PécsDivision of Gastroenterology, First Department of Medicine, Medical School, University of PécsDivision of Gastroenterology, First Department of Medicine, Medical School, University of PécsDivision of Gastroenterology, First Department of Medicine, Medical School, University of PécsDivision of Gastroenterology, First Department of Medicine, Medical School, University of PécsDivision of Gastroenterology, First Department of Medicine, Medical School, University of PécsDivision of Gastroenterology, First Department of Medicine, Medical School, University of PécsDivision of Gastroenterology, First Department of Medicine, Medical School, University of PécsDepartment of Medical Imaging, Medical School, University of PécsDepartment of Emergency Medicine, Medical School, University of PécsDepartment of Laboratory Medicine, Medical School, University of PécsInstitute for Translational Medicine, Medical School, University of PécsDepartment of Medicine, University of SzegedPeterfy HospitalDr. Bugyi István HospitalDepartment of Gastroenterology, BMKK Dr Rethy Pal HospitalCounty Emergency Clinical Hospital of Târgu Mures - Gastroenterology Clinic and University of Medicine, Pharmacy, Sciences and Technology “George Emil Palade”Pándy Kálmán Hospital of Békés CountyMarkusovszky University Teaching HospitalBorsod-Abaúj-Zemplén County Hospital and University Teaching HospitalHealthcare Center of County CsongrádDepartment of Gastroenterology, Institute of Internal Medicine, Faculty of Medicine, University of DebrecenInstitute for Translational Medicine, Medical School, University of PécsInstitute for Translational Medicine, Medical School, University of PécsInstitute for Translational Medicine, Medical School, University of PécsInstitute of Pancreatic Diseases, Semmelweis UniversityInstitute of Pancreatic Diseases, Semmelweis UniversityInstitute of Pancreatic Diseases, Semmelweis UniversityInstitute of Pancreatic Diseases, Semmelweis UniversityInstitute of Pancreatic Diseases, Semmelweis UniversityInstitute of Pancreatic Diseases, Semmelweis UniversityInstitute of Pancreatic Diseases, Semmelweis UniversityInstitute of Pancreatic Diseases, Semmelweis UniversityInstitute of Pancreatic Diseases, Semmelweis UniversityInstitute of Pancreatic Diseases, Semmelweis UniversityInstitute of Pancreatic Diseases, Semmelweis UniversityDepartment of Laboratory Medicine, Semmelweis UniversityMTA-SE Cardiovascular Imaging Research Group, Medical Imaging Centre, Semmelweis UniversityDepartment for Surgery, Hungarian Defence Forces - Medical CentreInstitute of Pancreatic Diseases, Semmelweis UniversityInstitute of Pancreatic Diseases, Semmelweis UniversityMedical Imaging Centre, Department of Radiology, Semmelweis UniversityCentre for Translational Medicine, Semmelweis UniversityCentre for Translational Medicine, Semmelweis UniversityAbstract There are several overlapping clinical practice guidelines in acute pancreatitis (AP), however, none of them contains suggestions on patient discharge. The Hungarian Pancreatic Study Group (HPSG) has recently developed a laboratory data and symptom-based discharge protocol which needs to be validated. (1) A survey was conducted involving all members of the International Association of Pancreatology (IAP) to understand the characteristics of international discharge protocols. (2) We investigated the safety and effectiveness of the HPSG-discharge protocol. According to our international survey, 87.5% (49/56) of the centres had no discharge protocol. Patients discharged based on protocols have a significantly shorter median length of hospitalization (LOH) (7 (5;10) days vs. 8 (5;12) days) p < 0.001), and a lower rate of readmission due to recurrent AP episodes (p = 0.005). There was no difference in median discharge CRP level among the international cohorts (p = 0.586). HPSG-protocol resulted in the shortest LOH (6 (5;9) days) and highest median CRP (35.40 (13.78; 68.40) mg/l). Safety was confirmed by the low rate of readmittance (n = 35; 5%). Discharge protocol is necessary in AP. The discharge protocol used in this study is the first clinically proven protocol. Developing and testifying further protocols are needed to better standardize patients’ care.https://doi.org/10.1038/s41598-023-48480-z |
| spellingShingle | Rita Nagy Klementina Ocskay Zoltán Sipos Andrea Szentesi Áron Vincze László Czakó Ferenc Izbéki Natalia V. Shirinskaya Vladimir L. Poluektov Alexandr N. Zolotov Yin Zhu Liang Xia Wenhua He Robert Sutton Peter Szatmary Rajarshi Mukherjee Isobel Saffron Burridge Emma Wauchope Elsa Francisco David Aparicio Bruno Pinto António Gomes Vitor Nunes Vasile Marcel Tantau Emanuela Denisa Sagau Alina Ioana Tantau Andra Iulia Suceveanu Cristina Tocia Andrei Dumitru Elizabeth Pando Piero Alberti Arturo Cirera Xavier Molero Hong Sik Lee Min Kyu Jung Eui Joo Kim Sanghyub Lee María Lourdes Ruiz Rebollo Reyes Busta Nistal Sandra Izquierdo Santervas Dusan Lesko Marek Soltes Jozef Radonak Hubert Zatorski Ewa Małecka-Panas Adam Fabisiak M. Susak Yaroslav V. Maksymenko Mykhailo A. Tkachenko Olekcandr Giedrius Barauskas Vytautas Simanaitis Povilas Ignatavicius Mariana Jinga Vasile-Daniel Balaban Cristina Patoni Liang Gong Kai Song Yunlong Li T. Cúrdia Gonçalves Marta Freitas Vítor Macedo Marlies Vornhuelz Sarah Klauss Georg Beyer Aydin Seref Koksal Mukaddes Tozlu Ahmet Tarik Eminler Nuria Torres Monclús Eva Pijoan Comas Juan Armando Rodriguez Oballe Łukasz Nawacki Stanisław Głuszek Alberto Rama-Fernández Marco Galego Daniel de la Iglesia Umut Emre Aykut Deniz Güney Duman Rahmi Aslan Adriana Gherbon Lihui Deng Wei Huang Qing Xia Goran Poropat Anja Radovan Luka Vranić Claudio Ricci Carlo Ingaldi Riccardo Casadei Ionut Negoi Cezar Ciubotaru Florin Mihail Iordache Gabriel Constantinescu Vasile Sandru Engin Altintas Hatice Rizaoglu Balci Júlio Constantino Débora Aveiro Jorge Pereira Suleyman Gunay Seda Misirlioglu Sucan Oleksiy Dronov Inna Kovalska Nikhil Bush Surinder Singh Rana Serge Chooklin Serhii Chuklin Ionut Adrian Saizu Cristian Gheorghe Philipp Göltl Michael Hirth Radu Bogdan Mateescu Geanina Papuc Georgi Angelov Minkov Emil Tihomirov Enchev Laura Mastrangelo Elio Jovine Weiwei Chen Quping Zhu Anita Gąsiorowska Natalia Fabisiak Mihailo Bezmarevic Andrey Litvin Martina Cattani Mottes Eun Kwang Choi Peter Bánovčin Lenka Nosáková Mila Dimitrova Kovacheva-Slavova Ali Kchaou Ahmed Tlili Marco V. Marino Katarzyna Kusnierz Artautas Mickevicius Marcus Hollenbach Pavol Molcan Orestis Ioannidis Mark Valerievich Tokarev Ali Tüzün Ince Ivan Albertovich Semenenko Shamil Galeev Elena Ramírez-Maldonado Ville Sallinen Petr Pencik Judit Bajor Patricia Sarlós Roland Hágendorn Szilárd Gódi Imre Szabó József Czimmer Gabriella Pár Anita Illés Nándor Faluhelyi Péter Kanizsai Tamás Nagy Alexandra Mikó Balázs Németh József Hamvas Barnabás Bod Márta Varga Imola Török János Novák Árpád Patai János Sümegi Csaba Góg Mária Papp Bálint Erőss Szilárd Váncsa Brigitta Teutsch Katalin Márta Péter Jenő Hegyi Tamás Tornai Balázs Lázár Tamás Hussein Dorottya Tarján Mónika Lipp Beáta Kovács Orsolya Urbán Emese Fürst Edina Tari Ibolya Kocsis Pál Maurovich-Horvát Balázs Tihanyi Orsolya Eperjesi Zita Kormos Pál Ákos Deák Andrea Párniczky Péter Hegyi Discharge protocol in acute pancreatitis: an international survey and cohort analysis Scientific Reports |
| title | Discharge protocol in acute pancreatitis: an international survey and cohort analysis |
| title_full | Discharge protocol in acute pancreatitis: an international survey and cohort analysis |
| title_fullStr | Discharge protocol in acute pancreatitis: an international survey and cohort analysis |
| title_full_unstemmed | Discharge protocol in acute pancreatitis: an international survey and cohort analysis |
| title_short | Discharge protocol in acute pancreatitis: an international survey and cohort analysis |
| title_sort | discharge protocol in acute pancreatitis an international survey and cohort analysis |
| url | https://doi.org/10.1038/s41598-023-48480-z |
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