Domestically-Produced Monoclonal-Antibody-Based Means of Diagnosing Particularly Dangerous Infections
Currently, great significance is attached to the preparation of diagnostic drugs based on specific immunoreagents, which include monoclonal antibodies produced by hybridomas. The use of monoclonal antibodies is one of the important approaches for the detection of pathogens of particularly dangerous...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”
2022-01-01
|
| Series: | Проблемы особо опасных инфекций |
| Subjects: | |
| Online Access: | https://journal.microbe.ru/jour/article/view/1588 |
| _version_ | 1797220749754236928 |
|---|---|
| author | O. F. Kretenchuk |
| author_facet | O. F. Kretenchuk |
| author_sort | O. F. Kretenchuk |
| collection | DOAJ |
| description | Currently, great significance is attached to the preparation of diagnostic drugs based on specific immunoreagents, which include monoclonal antibodies produced by hybridomas. The use of monoclonal antibodies is one of the important approaches for the detection of pathogens of particularly dangerous infections – anthrax, brucellosis, tularemia, plague, cholera, glanders, and melioidosis. The review presents the main achievements of Russian scientists on obtaining such experimental drugs, and also pays attention to those sets of monoclonal reagents that are authorized in the Russian Federation. To date, three sets of reagents for detecting the causative agent of anthrax (latex agglutination, immunochromatographic method, multiplex immunofluorescence analysis) have been registered in our country on the basis of monoclonal antibodies; four sets of reagents for identifying the causative agent of tularemia (latex agglutination, immunochromatographic method, multiplex immunofluorescence analysis, dot-variant of enzyme immunoassay); three sets for the detection of plague microbe (enzyme immunoassay and immune chromatographic tests); five sets for cholera vibrios (slide agglutination, immunofluorescence, immune chromatographic method and enzyme immunoassay); two sets for the diagnosis of glanders and melioidosis (immunofluorescence); kits for detecting brucella have not been registered, there are only singular experimental designs. The involvement of modern drugs based on monoclonal antibodies in the diagnosis of particularly dangerous infections will improve the quality and reliability of laboratory analysis. |
| first_indexed | 2024-03-08T13:41:34Z |
| format | Article |
| id | doaj.art-a96ac6dcb40f426da5bf9bcd8549ba4d |
| institution | Directory Open Access Journal |
| issn | 0370-1069 2658-719X |
| language | Russian |
| last_indexed | 2024-04-24T12:54:29Z |
| publishDate | 2022-01-01 |
| publisher | Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe” |
| record_format | Article |
| series | Проблемы особо опасных инфекций |
| spelling | doaj.art-a96ac6dcb40f426da5bf9bcd8549ba4d2024-04-05T16:47:16ZrusFederal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”Проблемы особо опасных инфекций0370-10692658-719X2022-01-0104354510.21055/0370-1069-2021-4-35-451327Domestically-Produced Monoclonal-Antibody-Based Means of Diagnosing Particularly Dangerous InfectionsO. F. Kretenchuk0Rostov-on-Don Research Anti-Plague InstituteCurrently, great significance is attached to the preparation of diagnostic drugs based on specific immunoreagents, which include monoclonal antibodies produced by hybridomas. The use of monoclonal antibodies is one of the important approaches for the detection of pathogens of particularly dangerous infections – anthrax, brucellosis, tularemia, plague, cholera, glanders, and melioidosis. The review presents the main achievements of Russian scientists on obtaining such experimental drugs, and also pays attention to those sets of monoclonal reagents that are authorized in the Russian Federation. To date, three sets of reagents for detecting the causative agent of anthrax (latex agglutination, immunochromatographic method, multiplex immunofluorescence analysis) have been registered in our country on the basis of monoclonal antibodies; four sets of reagents for identifying the causative agent of tularemia (latex agglutination, immunochromatographic method, multiplex immunofluorescence analysis, dot-variant of enzyme immunoassay); three sets for the detection of plague microbe (enzyme immunoassay and immune chromatographic tests); five sets for cholera vibrios (slide agglutination, immunofluorescence, immune chromatographic method and enzyme immunoassay); two sets for the diagnosis of glanders and melioidosis (immunofluorescence); kits for detecting brucella have not been registered, there are only singular experimental designs. The involvement of modern drugs based on monoclonal antibodies in the diagnosis of particularly dangerous infections will improve the quality and reliability of laboratory analysis.https://journal.microbe.ru/jour/article/view/1588monoclonal antibodiesreagent panelcholeraplaguetularemiaanthraxbrucellosisglandersand melioidosis |
| spellingShingle | O. F. Kretenchuk Domestically-Produced Monoclonal-Antibody-Based Means of Diagnosing Particularly Dangerous Infections Проблемы особо опасных инфекций monoclonal antibodies reagent panel cholera plague tularemia anthrax brucellosis glanders and melioidosis |
| title | Domestically-Produced Monoclonal-Antibody-Based Means of Diagnosing Particularly Dangerous Infections |
| title_full | Domestically-Produced Monoclonal-Antibody-Based Means of Diagnosing Particularly Dangerous Infections |
| title_fullStr | Domestically-Produced Monoclonal-Antibody-Based Means of Diagnosing Particularly Dangerous Infections |
| title_full_unstemmed | Domestically-Produced Monoclonal-Antibody-Based Means of Diagnosing Particularly Dangerous Infections |
| title_short | Domestically-Produced Monoclonal-Antibody-Based Means of Diagnosing Particularly Dangerous Infections |
| title_sort | domestically produced monoclonal antibody based means of diagnosing particularly dangerous infections |
| topic | monoclonal antibodies reagent panel cholera plague tularemia anthrax brucellosis glanders and melioidosis |
| url | https://journal.microbe.ru/jour/article/view/1588 |
| work_keys_str_mv | AT ofkretenchuk domesticallyproducedmonoclonalantibodybasedmeansofdiagnosingparticularlydangerousinfections |