Ferroptosis in Cardiovascular Diseases: Current Status, Challenges, and Future Perspectives
Cardiovascular diseases (CVDs) are still a major cause of global mortality and disability, seriously affecting people’s lives. Due to the severity and complexity of these diseases, it is important to find new regulatory mechanisms to treat CVDs. Ferroptosis is a new kind of regulatory cell death cur...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-03-01
|
| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/12/3/390 |
| _version_ | 1797472708614684672 |
|---|---|
| author | Yi Guo Chanjun Lu Ke Hu Chuanqi Cai Weici Wang |
| author_facet | Yi Guo Chanjun Lu Ke Hu Chuanqi Cai Weici Wang |
| author_sort | Yi Guo |
| collection | DOAJ |
| description | Cardiovascular diseases (CVDs) are still a major cause of global mortality and disability, seriously affecting people’s lives. Due to the severity and complexity of these diseases, it is important to find new regulatory mechanisms to treat CVDs. Ferroptosis is a new kind of regulatory cell death currently being investigated. Increasing evidence showed that ferroptosis plays an important role in CVDs, such as in ischemia/reperfusion injury, heart failure, cardiomyopathy, and atherosclerosis. Protecting against CVDs by targeting ferroptosis is a promising approach; therefore, in this review, we summarized the latest regulatory mechanism of ferroptosis and the current studies related to each CVD, followed by critical perspectives on the ferroptotic treatment of CVDs and the future direction of this intriguing biology. |
| first_indexed | 2024-03-09T20:05:04Z |
| format | Article |
| id | doaj.art-a96c3d9f7e87421383b573e04c005422 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T20:05:04Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-a96c3d9f7e87421383b573e04c0054222023-11-24T00:35:15ZengMDPI AGBiomolecules2218-273X2022-03-0112339010.3390/biom12030390Ferroptosis in Cardiovascular Diseases: Current Status, Challenges, and Future PerspectivesYi Guo0Chanjun Lu1Ke Hu2Chuanqi Cai3Weici Wang4Clinic Center of Human Gene Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaCardiovascular diseases (CVDs) are still a major cause of global mortality and disability, seriously affecting people’s lives. Due to the severity and complexity of these diseases, it is important to find new regulatory mechanisms to treat CVDs. Ferroptosis is a new kind of regulatory cell death currently being investigated. Increasing evidence showed that ferroptosis plays an important role in CVDs, such as in ischemia/reperfusion injury, heart failure, cardiomyopathy, and atherosclerosis. Protecting against CVDs by targeting ferroptosis is a promising approach; therefore, in this review, we summarized the latest regulatory mechanism of ferroptosis and the current studies related to each CVD, followed by critical perspectives on the ferroptotic treatment of CVDs and the future direction of this intriguing biology.https://www.mdpi.com/2218-273X/12/3/390ferroptosiscardiovascular diseasesischemia/reperfusion injuryheart failurecardiomyopathyatherosclerosis |
| spellingShingle | Yi Guo Chanjun Lu Ke Hu Chuanqi Cai Weici Wang Ferroptosis in Cardiovascular Diseases: Current Status, Challenges, and Future Perspectives Biomolecules ferroptosis cardiovascular diseases ischemia/reperfusion injury heart failure cardiomyopathy atherosclerosis |
| title | Ferroptosis in Cardiovascular Diseases: Current Status, Challenges, and Future Perspectives |
| title_full | Ferroptosis in Cardiovascular Diseases: Current Status, Challenges, and Future Perspectives |
| title_fullStr | Ferroptosis in Cardiovascular Diseases: Current Status, Challenges, and Future Perspectives |
| title_full_unstemmed | Ferroptosis in Cardiovascular Diseases: Current Status, Challenges, and Future Perspectives |
| title_short | Ferroptosis in Cardiovascular Diseases: Current Status, Challenges, and Future Perspectives |
| title_sort | ferroptosis in cardiovascular diseases current status challenges and future perspectives |
| topic | ferroptosis cardiovascular diseases ischemia/reperfusion injury heart failure cardiomyopathy atherosclerosis |
| url | https://www.mdpi.com/2218-273X/12/3/390 |
| work_keys_str_mv | AT yiguo ferroptosisincardiovasculardiseasescurrentstatuschallengesandfutureperspectives AT chanjunlu ferroptosisincardiovasculardiseasescurrentstatuschallengesandfutureperspectives AT kehu ferroptosisincardiovasculardiseasescurrentstatuschallengesandfutureperspectives AT chuanqicai ferroptosisincardiovasculardiseasescurrentstatuschallengesandfutureperspectives AT weiciwang ferroptosisincardiovasculardiseasescurrentstatuschallengesandfutureperspectives |