An HSP90 Inhibitor Overcomes FLT3 Inhibitor Resistance in FLT3/ITD-Positive Leukemia Cells with an N676K Mutation

An HSP90 Inhibitor Overcomes FLT3 Inhibitor Resistance in FLT3/ITD-Positive Leukemia Cells with an N676K Mutation

<i>FLT3</i> mutations are frequently identified in acute myeloid leukemia (AML). In particular, FLT3-ITD is known to be an indicator of a poor prognosis. FLT3 inhibitors have improved the treatment outcomes of AML patients with mutated FLT3. However, several drug-resistance mechanisms ha...

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Bibliographic Details
Main Authors: Hiraku Ogata, Yosuke Minami
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:International Journal of Translational Medicine
Subjects:
acute myeloid leukemia
FLT3 mutation
heat shock protein 90
Online Access:https://www.mdpi.com/2673-8937/3/3/27

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