Circulating tumor cells participate in the formation of microvascular invasion and impact on clinical outcomes in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a common malignant tumor worldwide. Although the treatment strategies have been improved in recent years, the long-term prognosis of HCC is far from satisfactory mainly due to high postoperative recurrence and metastasis rate. Vascular tumor thrombus, including micr...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-11-01
|
| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2023.1265866/full |
| _version_ | 1797640146530598912 |
|---|---|
| author | Bin Sun Wei-Dan Ji Wen-Chao Wang Lei Chen Jun-Yong Ma Er-Jiang Tang Mou-Bin Lin Xiao-Feng Zhang |
| author_facet | Bin Sun Wei-Dan Ji Wen-Chao Wang Lei Chen Jun-Yong Ma Er-Jiang Tang Mou-Bin Lin Xiao-Feng Zhang |
| author_sort | Bin Sun |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) is a common malignant tumor worldwide. Although the treatment strategies have been improved in recent years, the long-term prognosis of HCC is far from satisfactory mainly due to high postoperative recurrence and metastasis rate. Vascular tumor thrombus, including microvascular invasion (MVI) and portal vein tumor thrombus (PVTT), affects the outcome of hepatectomy and liver transplantation. If vascular invasion could be found preoperatively, especially the risk of MVI, more reasonable surgical selection will be chosen to reduce the risk of postoperative recurrence and metastasis. However, there is a lack of reliable prediction methods, and the formation mechanism of MVI/PVTT is still unclear. At present, there is no study to explore the possibility of tumor thrombus formation from a single circulating tumor cell (CTC) of HCC, nor any related study to describe the possible leading role and molecular mechanism of HCC CTCs as an important component of MVI/PVTT. In this study, we review the current understanding of MVI and possible mechanisms, discuss the function of CTCs in the formation of MVI and interaction with immune cells in the circulation. In conclusion, we discuss implications for potential therapeutic targets and the prospect of clinical treatment of HCC. |
| first_indexed | 2024-03-11T13:27:43Z |
| format | Article |
| id | doaj.art-a971196182904e7298071966395caa2c |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-03-11T13:27:43Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-a971196182904e7298071966395caa2c2023-11-03T05:51:50ZengFrontiers Media S.A.Frontiers in Genetics1664-80212023-11-011410.3389/fgene.2023.12658661265866Circulating tumor cells participate in the formation of microvascular invasion and impact on clinical outcomes in hepatocellular carcinomaBin Sun0Wei-Dan Ji1Wen-Chao Wang2Lei Chen3Jun-Yong Ma4Er-Jiang Tang5Mou-Bin Lin6Xiao-Feng Zhang7Center for Clinical Research and Translational Medicine, Yangpu Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Molecular Oncology, Eastern Hepatobiliary Surgical Hospital and National Center for Liver Cancer, Navy Military Medical University, Shanghai, ChinaDepartment of General Surgery, Yangpu Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of General Surgery, Yangpu Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Navy Military Medical University, Shanghai, ChinaCenter for Clinical Research and Translational Medicine, Yangpu Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of General Surgery, Yangpu Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Navy Military Medical University, Shanghai, ChinaHepatocellular carcinoma (HCC) is a common malignant tumor worldwide. Although the treatment strategies have been improved in recent years, the long-term prognosis of HCC is far from satisfactory mainly due to high postoperative recurrence and metastasis rate. Vascular tumor thrombus, including microvascular invasion (MVI) and portal vein tumor thrombus (PVTT), affects the outcome of hepatectomy and liver transplantation. If vascular invasion could be found preoperatively, especially the risk of MVI, more reasonable surgical selection will be chosen to reduce the risk of postoperative recurrence and metastasis. However, there is a lack of reliable prediction methods, and the formation mechanism of MVI/PVTT is still unclear. At present, there is no study to explore the possibility of tumor thrombus formation from a single circulating tumor cell (CTC) of HCC, nor any related study to describe the possible leading role and molecular mechanism of HCC CTCs as an important component of MVI/PVTT. In this study, we review the current understanding of MVI and possible mechanisms, discuss the function of CTCs in the formation of MVI and interaction with immune cells in the circulation. In conclusion, we discuss implications for potential therapeutic targets and the prospect of clinical treatment of HCC.https://www.frontiersin.org/articles/10.3389/fgene.2023.1265866/fullcirculating tumor cellsmicrovascular invasionrecurrence and metastasisclinical treatmenthepatocellular carcinoma |
| spellingShingle | Bin Sun Wei-Dan Ji Wen-Chao Wang Lei Chen Jun-Yong Ma Er-Jiang Tang Mou-Bin Lin Xiao-Feng Zhang Circulating tumor cells participate in the formation of microvascular invasion and impact on clinical outcomes in hepatocellular carcinoma Frontiers in Genetics circulating tumor cells microvascular invasion recurrence and metastasis clinical treatment hepatocellular carcinoma |
| title | Circulating tumor cells participate in the formation of microvascular invasion and impact on clinical outcomes in hepatocellular carcinoma |
| title_full | Circulating tumor cells participate in the formation of microvascular invasion and impact on clinical outcomes in hepatocellular carcinoma |
| title_fullStr | Circulating tumor cells participate in the formation of microvascular invasion and impact on clinical outcomes in hepatocellular carcinoma |
| title_full_unstemmed | Circulating tumor cells participate in the formation of microvascular invasion and impact on clinical outcomes in hepatocellular carcinoma |
| title_short | Circulating tumor cells participate in the formation of microvascular invasion and impact on clinical outcomes in hepatocellular carcinoma |
| title_sort | circulating tumor cells participate in the formation of microvascular invasion and impact on clinical outcomes in hepatocellular carcinoma |
| topic | circulating tumor cells microvascular invasion recurrence and metastasis clinical treatment hepatocellular carcinoma |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2023.1265866/full |
| work_keys_str_mv | AT binsun circulatingtumorcellsparticipateintheformationofmicrovascularinvasionandimpactonclinicaloutcomesinhepatocellularcarcinoma AT weidanji circulatingtumorcellsparticipateintheformationofmicrovascularinvasionandimpactonclinicaloutcomesinhepatocellularcarcinoma AT wenchaowang circulatingtumorcellsparticipateintheformationofmicrovascularinvasionandimpactonclinicaloutcomesinhepatocellularcarcinoma AT leichen circulatingtumorcellsparticipateintheformationofmicrovascularinvasionandimpactonclinicaloutcomesinhepatocellularcarcinoma AT junyongma circulatingtumorcellsparticipateintheformationofmicrovascularinvasionandimpactonclinicaloutcomesinhepatocellularcarcinoma AT erjiangtang circulatingtumorcellsparticipateintheformationofmicrovascularinvasionandimpactonclinicaloutcomesinhepatocellularcarcinoma AT moubinlin circulatingtumorcellsparticipateintheformationofmicrovascularinvasionandimpactonclinicaloutcomesinhepatocellularcarcinoma AT xiaofengzhang circulatingtumorcellsparticipateintheformationofmicrovascularinvasionandimpactonclinicaloutcomesinhepatocellularcarcinoma |