Effect of different post-partum therapeutic protocols with intrauterine oxytetracycline, oxytocin and/or GnRH injection in post-kidding goats on oxytetracyclines residues in goat milk and postpartum ovarian resumption with referring to clinical and haematological pictures
Abstract Background The post-parturient period in goat had marked changes in an animal’s endocrine and metabolic status as well as by reduction in feed intake when the nutrient demand for impending lactogenesis was increasing. The current study aimed to monitor the residues of oxytetracycline in Bal...
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| Format: | Article |
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BMC
2023-09-01
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| Series: | BMC Veterinary Research |
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| Online Access: | https://doi.org/10.1186/s12917-023-03706-0 |
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| author | Asem M. Zakaria Taher Al-Daek Enas Elmeligy Ragab H. Mohamed Eman M. Abu El-Naga Haitham H. Mohammed Abdulrahman Abdulkarim Mohammed Abdelhadi Ali Khaled. A. Khesruf Arafat Khalphallah |
| author_facet | Asem M. Zakaria Taher Al-Daek Enas Elmeligy Ragab H. Mohamed Eman M. Abu El-Naga Haitham H. Mohammed Abdulrahman Abdulkarim Mohammed Abdelhadi Ali Khaled. A. Khesruf Arafat Khalphallah |
| author_sort | Asem M. Zakaria |
| collection | DOAJ |
| description | Abstract Background The post-parturient period in goat had marked changes in an animal’s endocrine and metabolic status as well as by reduction in feed intake when the nutrient demand for impending lactogenesis was increasing. The current study aimed to monitor the residues of oxytetracycline in Baladi goat milk and their hazards on public health as well as the time required until complete disappearance of this medicament from milk through following up periods included 0, 12, 24, 36, 48, 60, 72, 84, 96 and 120 h in post-kidding goat following intrauterine application of oxytetracycline. The study also compared between the efficacy of oxytetracycline only, oxytetracycline with oxytocin, or oxytetracycline with GnRH, through monitoring the clinical findings and haematological pictures at days 0, 5 and 7 post-partum as well as studying the changes in numbers and size of follicles at days 15, 30 and 45 postpartum after different treatments strategies in different groups i.e. Control healthy goat (Contgr), Oxytetracycline treated goat (Oxytetgr), Oxytetracycline-oxytocin treated goat (Oxytet-Oxytogr) and Oxytetracycline-GnRH treated goat (Oxytet-GnRHgr). The study was carried out on clinically healthy Baladi goats (n = 40) that gave birth recently. They were divided into 4 equal groups (n = 10 goats for each); Contgr which received no medication after birth, Oxytetgr which administrated oxytetracycline tablets intrauterine at day of birth, Oxytet-Oxytogr which treated by oxytetracycline tablets intrauterine at day of birth followed by oxytocin injection at 3rd day after birth, and Oxytet-GnRHgr which treated by oxytetracycline tablets intrauterine at day of birth followed by GNRH injection at 3rd day after birth. Results and Conclusions The study concluded the highest oxytetracyclines residues in goats’ milk were reported after 36 h following intrauterine oxytetracycline application where complete disappearance of oxytetracyclines residues in goats’ milk required 120 h elapsed after intrauterine oxytetracycline application in which the goats milk became safe for human consumption. The study also reported powerful influence of the applied variable therapeutic regimens on post-partum ovarian resumption through clear significant variations in numbers and sizes of follicles either between different goats’ groups within the same day, or between days 15, 30 and 45 post-partum within each independent goat group. |
| first_indexed | 2024-03-09T15:06:12Z |
| format | Article |
| id | doaj.art-a97209a990df4863a94d9dfd5c8600c1 |
| institution | Directory Open Access Journal |
| issn | 1746-6148 |
| language | English |
| last_indexed | 2024-03-09T15:06:12Z |
| publishDate | 2023-09-01 |
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| series | BMC Veterinary Research |
| spelling | doaj.art-a97209a990df4863a94d9dfd5c8600c12023-11-26T13:38:24ZengBMCBMC Veterinary Research1746-61482023-09-0119111210.1186/s12917-023-03706-0Effect of different post-partum therapeutic protocols with intrauterine oxytetracycline, oxytocin and/or GnRH injection in post-kidding goats on oxytetracyclines residues in goat milk and postpartum ovarian resumption with referring to clinical and haematological picturesAsem M. Zakaria0Taher Al-Daek1Enas Elmeligy2Ragab H. Mohamed3Eman M. Abu El-Naga4Haitham H. Mohammed5Abdulrahman Abdulkarim6Mohammed Abdelhadi Ali7Khaled. A. Khesruf8Arafat Khalphallah9Department of Food Hygiene, Faculty of Veterinary Medicine, Aswan UniversityFaculty of Veterinary Medicine, Omar Al- Mukhtar UniversityVeterinary Teaching Hospital, Faculty of Veterinary Medicine, Assiut UniversityDepartment of Theriogenology, Obstetrics, and Artificial Insemination, Faculty of Veterinary Medicine, Aswan UniversityDepartment of Theriogenology, Obstetrics, and Artificial Insemination, Faculty of Veterinary Medicine, Aswan UniversityDepartment of Rangeland, Wildlife and Fisheries Management, Texas A&M UniversityFaculty of Veterinary Medicine, Omar Al- Mukhtar UniversityDepartment of Forensic medicine and Toxicology, Faculty of Veterinary Medicine, Assiut UniversityDepartment of Animal diseases, Faculty of Veterinary Medicine, Aleppo UniversityDivision of Internal Medicine, Department of Animal Medicine, Faculty of Veterinary Medicine, Assiut UniversityAbstract Background The post-parturient period in goat had marked changes in an animal’s endocrine and metabolic status as well as by reduction in feed intake when the nutrient demand for impending lactogenesis was increasing. The current study aimed to monitor the residues of oxytetracycline in Baladi goat milk and their hazards on public health as well as the time required until complete disappearance of this medicament from milk through following up periods included 0, 12, 24, 36, 48, 60, 72, 84, 96 and 120 h in post-kidding goat following intrauterine application of oxytetracycline. The study also compared between the efficacy of oxytetracycline only, oxytetracycline with oxytocin, or oxytetracycline with GnRH, through monitoring the clinical findings and haematological pictures at days 0, 5 and 7 post-partum as well as studying the changes in numbers and size of follicles at days 15, 30 and 45 postpartum after different treatments strategies in different groups i.e. Control healthy goat (Contgr), Oxytetracycline treated goat (Oxytetgr), Oxytetracycline-oxytocin treated goat (Oxytet-Oxytogr) and Oxytetracycline-GnRH treated goat (Oxytet-GnRHgr). The study was carried out on clinically healthy Baladi goats (n = 40) that gave birth recently. They were divided into 4 equal groups (n = 10 goats for each); Contgr which received no medication after birth, Oxytetgr which administrated oxytetracycline tablets intrauterine at day of birth, Oxytet-Oxytogr which treated by oxytetracycline tablets intrauterine at day of birth followed by oxytocin injection at 3rd day after birth, and Oxytet-GnRHgr which treated by oxytetracycline tablets intrauterine at day of birth followed by GNRH injection at 3rd day after birth. Results and Conclusions The study concluded the highest oxytetracyclines residues in goats’ milk were reported after 36 h following intrauterine oxytetracycline application where complete disappearance of oxytetracyclines residues in goats’ milk required 120 h elapsed after intrauterine oxytetracycline application in which the goats milk became safe for human consumption. The study also reported powerful influence of the applied variable therapeutic regimens on post-partum ovarian resumption through clear significant variations in numbers and sizes of follicles either between different goats’ groups within the same day, or between days 15, 30 and 45 post-partum within each independent goat group.https://doi.org/10.1186/s12917-023-03706-0Clinical findingsGoatGnRHMilk oxytetracyclines residuesOxytocinFollicles |
| spellingShingle | Asem M. Zakaria Taher Al-Daek Enas Elmeligy Ragab H. Mohamed Eman M. Abu El-Naga Haitham H. Mohammed Abdulrahman Abdulkarim Mohammed Abdelhadi Ali Khaled. A. Khesruf Arafat Khalphallah Effect of different post-partum therapeutic protocols with intrauterine oxytetracycline, oxytocin and/or GnRH injection in post-kidding goats on oxytetracyclines residues in goat milk and postpartum ovarian resumption with referring to clinical and haematological pictures BMC Veterinary Research Clinical findings Goat GnRH Milk oxytetracyclines residues Oxytocin Follicles |
| title | Effect of different post-partum therapeutic protocols with intrauterine oxytetracycline, oxytocin and/or GnRH injection in post-kidding goats on oxytetracyclines residues in goat milk and postpartum ovarian resumption with referring to clinical and haematological pictures |
| title_full | Effect of different post-partum therapeutic protocols with intrauterine oxytetracycline, oxytocin and/or GnRH injection in post-kidding goats on oxytetracyclines residues in goat milk and postpartum ovarian resumption with referring to clinical and haematological pictures |
| title_fullStr | Effect of different post-partum therapeutic protocols with intrauterine oxytetracycline, oxytocin and/or GnRH injection in post-kidding goats on oxytetracyclines residues in goat milk and postpartum ovarian resumption with referring to clinical and haematological pictures |
| title_full_unstemmed | Effect of different post-partum therapeutic protocols with intrauterine oxytetracycline, oxytocin and/or GnRH injection in post-kidding goats on oxytetracyclines residues in goat milk and postpartum ovarian resumption with referring to clinical and haematological pictures |
| title_short | Effect of different post-partum therapeutic protocols with intrauterine oxytetracycline, oxytocin and/or GnRH injection in post-kidding goats on oxytetracyclines residues in goat milk and postpartum ovarian resumption with referring to clinical and haematological pictures |
| title_sort | effect of different post partum therapeutic protocols with intrauterine oxytetracycline oxytocin and or gnrh injection in post kidding goats on oxytetracyclines residues in goat milk and postpartum ovarian resumption with referring to clinical and haematological pictures |
| topic | Clinical findings Goat GnRH Milk oxytetracyclines residues Oxytocin Follicles |
| url | https://doi.org/10.1186/s12917-023-03706-0 |
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