The Transcriptomic Profile of Monocytes from Patients With Sjögren’s Syndrome Is Associated With Inflammatory Parameters and Is Mimicked by Circulating Mediators

The Transcriptomic Profile of Monocytes from Patients With Sjögren’s Syndrome Is Associated With Inflammatory Parameters and Is Mimicked by Circulating Mediators

Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease characterized by infiltration of the exocrine glands and prominent B cell hyperactivity. Considering the key role of monocytes in promoting B cell hyperactivity, we performed RNA-sequencing analysis of CD14+ monocytes from patients wi...

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Bibliographic Details
Main Authors: Ana P. Lopes, Cornelis P. J. Bekker, Maarten R. Hillen, Sofie L. M. Blokland, Anneline C. Hinrichs, Aridaman Pandit, Aike A. Kruize, Timothy R. D. J. Radstake, Joel A. G. van Roon
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
Sjögren’s syndrome
monocytes
transcriptome
WGCNA
type-I interferons
systemic mediators
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.701656/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.701656/full

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