Diabetic cardiomyopathy in Zucker diabetic fatty rats: the forgotten right ventricle
<p>Abstract</p> <p>Background</p> <p>In patients with myocardial infarction or heart failure, right ventricular (RV) dysfunction is associated with death, shock and arrhythmias. In patients with type 2 diabetes mellitus, structural and functional alterations of the left...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2010-06-01
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| Series: | Cardiovascular Diabetology |
| Online Access: | http://www.cardiab.com/content/9/1/25 |
| _version_ | 1818664843907956736 |
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| author | Lubberink Mark Huisman Marc C Handoko Louis M Vlasblom Ronald Bosmans Joanna WAM van den Brom Charissa E Molthoff Carla FM Lammertsma Adriaan A Ouwens Margriet D Diamant Michaela Boer Christa |
| author_facet | Lubberink Mark Huisman Marc C Handoko Louis M Vlasblom Ronald Bosmans Joanna WAM van den Brom Charissa E Molthoff Carla FM Lammertsma Adriaan A Ouwens Margriet D Diamant Michaela Boer Christa |
| author_sort | Lubberink Mark |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>In patients with myocardial infarction or heart failure, right ventricular (RV) dysfunction is associated with death, shock and arrhythmias. In patients with type 2 diabetes mellitus, structural and functional alterations of the left ventricle (LV) are highly prevalent, however, little is known about the impact of diabetes on RV characteristics. The purpose of the present study was to investigate whether LV changes are paralleled by RV alterations in a rat model of diabetes.</p> <p>Methods</p> <p>Zucker diabetic fatty (ZDF) and control (ZL) rats underwent echocardiography and positron emission tomography (PET) scanning using [<sup>18</sup>F]-2-fluoro-2-deoxy-D-glucose under hyperinsulinaemic euglycaemic clamp conditions. Glucose, insulin, triglycerides and fatty acids were assessed from trunk blood. Another group of rats received an insulin or saline injection to study RV insulin signaling.</p> <p>Results</p> <p>ZDF rats developed hyperglycaemia, hyperinsulinaemia and dyslipidaemia (all p < 0.05). Echocardiography revealed depressed LV fractional shortening and tricuspid annular plane systolic excursion (TAPSE) in ZDF vs. ZL rats (both p < 0.05). A decrease in LV and RV insulin-mediated glucose utilisation was found in ZDF vs. ZL rats (both p < 0.05). LV associated with RV with respect to systolic function (r = 0.86, p < 0.05) and glucose utilisation (r = 0.74, p < 0.05). TAPSE associated with RV MRglu (r = 0.92, p < 0.05) and <it>M</it>-value (r = 0.91, p < 0.0001) and RV MRglu associated with <it>M</it>-value (r = 0.77, p < 0.05). Finally, reduced RV insulin-stimulated phosphorylation of Akt was found in ZDF vs. ZL (p < 0.05).</p> <p>Conclusions</p> <p>LV changes were paralleled by RV alterations in insulin-stimulated glucose utilisation and RV systolic function in a rat model of diabetes, which may be attributed to ventricular interdependence as well as to the uniform effect of diabetes. Since diabetic patients are prone to develop diabetic cardiomyopathy and myocardial ischaemia, it might be suggested that RV dysfunction plays a central role in cardiac abnormalities in this population.</p> |
| first_indexed | 2024-12-17T05:39:11Z |
| format | Article |
| id | doaj.art-a9726acbb724438b9d250ad1af9d9fb7 |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-12-17T05:39:11Z |
| publishDate | 2010-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-a9726acbb724438b9d250ad1af9d9fb72022-12-21T22:01:31ZengBMCCardiovascular Diabetology1475-28402010-06-01912510.1186/1475-2840-9-25Diabetic cardiomyopathy in Zucker diabetic fatty rats: the forgotten right ventricleLubberink MarkHuisman Marc CHandoko Louis MVlasblom RonaldBosmans Joanna WAMvan den Brom Charissa EMolthoff Carla FMLammertsma Adriaan AOuwens Margriet DDiamant MichaelaBoer Christa<p>Abstract</p> <p>Background</p> <p>In patients with myocardial infarction or heart failure, right ventricular (RV) dysfunction is associated with death, shock and arrhythmias. In patients with type 2 diabetes mellitus, structural and functional alterations of the left ventricle (LV) are highly prevalent, however, little is known about the impact of diabetes on RV characteristics. The purpose of the present study was to investigate whether LV changes are paralleled by RV alterations in a rat model of diabetes.</p> <p>Methods</p> <p>Zucker diabetic fatty (ZDF) and control (ZL) rats underwent echocardiography and positron emission tomography (PET) scanning using [<sup>18</sup>F]-2-fluoro-2-deoxy-D-glucose under hyperinsulinaemic euglycaemic clamp conditions. Glucose, insulin, triglycerides and fatty acids were assessed from trunk blood. Another group of rats received an insulin or saline injection to study RV insulin signaling.</p> <p>Results</p> <p>ZDF rats developed hyperglycaemia, hyperinsulinaemia and dyslipidaemia (all p < 0.05). Echocardiography revealed depressed LV fractional shortening and tricuspid annular plane systolic excursion (TAPSE) in ZDF vs. ZL rats (both p < 0.05). A decrease in LV and RV insulin-mediated glucose utilisation was found in ZDF vs. ZL rats (both p < 0.05). LV associated with RV with respect to systolic function (r = 0.86, p < 0.05) and glucose utilisation (r = 0.74, p < 0.05). TAPSE associated with RV MRglu (r = 0.92, p < 0.05) and <it>M</it>-value (r = 0.91, p < 0.0001) and RV MRglu associated with <it>M</it>-value (r = 0.77, p < 0.05). Finally, reduced RV insulin-stimulated phosphorylation of Akt was found in ZDF vs. ZL (p < 0.05).</p> <p>Conclusions</p> <p>LV changes were paralleled by RV alterations in insulin-stimulated glucose utilisation and RV systolic function in a rat model of diabetes, which may be attributed to ventricular interdependence as well as to the uniform effect of diabetes. Since diabetic patients are prone to develop diabetic cardiomyopathy and myocardial ischaemia, it might be suggested that RV dysfunction plays a central role in cardiac abnormalities in this population.</p>http://www.cardiab.com/content/9/1/25 |
| spellingShingle | Lubberink Mark Huisman Marc C Handoko Louis M Vlasblom Ronald Bosmans Joanna WAM van den Brom Charissa E Molthoff Carla FM Lammertsma Adriaan A Ouwens Margriet D Diamant Michaela Boer Christa Diabetic cardiomyopathy in Zucker diabetic fatty rats: the forgotten right ventricle Cardiovascular Diabetology |
| title | Diabetic cardiomyopathy in Zucker diabetic fatty rats: the forgotten right ventricle |
| title_full | Diabetic cardiomyopathy in Zucker diabetic fatty rats: the forgotten right ventricle |
| title_fullStr | Diabetic cardiomyopathy in Zucker diabetic fatty rats: the forgotten right ventricle |
| title_full_unstemmed | Diabetic cardiomyopathy in Zucker diabetic fatty rats: the forgotten right ventricle |
| title_short | Diabetic cardiomyopathy in Zucker diabetic fatty rats: the forgotten right ventricle |
| title_sort | diabetic cardiomyopathy in zucker diabetic fatty rats the forgotten right ventricle |
| url | http://www.cardiab.com/content/9/1/25 |
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