Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine
The ERK signalling pathway regulates homeostasis of the intestinal epithelium. Here the authors identify two modes of ERK activity generated independently from EGFR and ErbB2 receptor and whose balance in cancer is shifted by Wnt pathway activation, resulting in enhanced sensitivity to EGFR inhibito...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-04527-8 |
| _version_ | 1818682492003024896 |
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| author | Yu Muta Yoshihisa Fujita Kenta Sumiyama Atsuro Sakurai M. Mark Taketo Tsutomu Chiba Hiroshi Seno Kazuhiro Aoki Michiyuki Matsuda Masamichi Imajo |
| author_facet | Yu Muta Yoshihisa Fujita Kenta Sumiyama Atsuro Sakurai M. Mark Taketo Tsutomu Chiba Hiroshi Seno Kazuhiro Aoki Michiyuki Matsuda Masamichi Imajo |
| author_sort | Yu Muta |
| collection | DOAJ |
| description | The ERK signalling pathway regulates homeostasis of the intestinal epithelium. Here the authors identify two modes of ERK activity generated independently from EGFR and ErbB2 receptor and whose balance in cancer is shifted by Wnt pathway activation, resulting in enhanced sensitivity to EGFR inhibitors. |
| first_indexed | 2024-12-17T10:19:42Z |
| format | Article |
| id | doaj.art-a9728e66391f48928bceb937aa59748e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T10:19:42Z |
| publishDate | 2018-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a9728e66391f48928bceb937aa59748e2022-12-21T21:52:50ZengNature PortfolioNature Communications2041-17232018-06-019111610.1038/s41467-018-04527-8Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestineYu Muta0Yoshihisa Fujita1Kenta Sumiyama2Atsuro Sakurai3M. Mark Taketo4Tsutomu Chiba5Hiroshi Seno6Kazuhiro Aoki7Michiyuki Matsuda8Masamichi Imajo9Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto UniversityDepartment of Systems Science, Graduate School of Informatics, Kyoto UniversityLaboratory for Mouse Genetic Engineering, Quantitative Biology Center, RIKENLaboratory of Bioimaging and Cell Signaling, Graduate School of Biostudies, Kyoto UniversityDivision of Experimental Therapeutics, Graduate School of Medicine, Kyoto UniversityDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto UniversityDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto UniversityDivision of Quantitative Biology, Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural SciencesDepartment of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto UniversityLaboratory of Bioimaging and Cell Signaling, Graduate School of Biostudies, Kyoto UniversityThe ERK signalling pathway regulates homeostasis of the intestinal epithelium. Here the authors identify two modes of ERK activity generated independently from EGFR and ErbB2 receptor and whose balance in cancer is shifted by Wnt pathway activation, resulting in enhanced sensitivity to EGFR inhibitors.https://doi.org/10.1038/s41467-018-04527-8 |
| spellingShingle | Yu Muta Yoshihisa Fujita Kenta Sumiyama Atsuro Sakurai M. Mark Taketo Tsutomu Chiba Hiroshi Seno Kazuhiro Aoki Michiyuki Matsuda Masamichi Imajo Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine Nature Communications |
| title | Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine |
| title_full | Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine |
| title_fullStr | Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine |
| title_full_unstemmed | Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine |
| title_short | Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine |
| title_sort | composite regulation of erk activity dynamics underlying tumour specific traits in the intestine |
| url | https://doi.org/10.1038/s41467-018-04527-8 |
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