Expanding the Topological Space of Bioactive Peptides
Naturally occurring peptides and proteins consist almost exclusively of linear or cyclic polypeptide chains. Our group explores the chemical space of peptides by redesigning their topology through the introduction of branching points in the peptide chain. Branched peptides are generally re...
| Main Authors: | , |
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| Format: | Article |
| Language: | deu |
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Swiss Chemical Society
2013-12-01
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| Series: | CHIMIA |
| Subjects: | |
| Online Access: | https://www.chimia.ch/chimia/article/view/5484 |
| _version_ | 1818294764801359872 |
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| author | Jean-Louis Reymond Tamis Darbre |
| author_facet | Jean-Louis Reymond Tamis Darbre |
| author_sort | Jean-Louis Reymond |
| collection | DOAJ |
| description |
Naturally occurring peptides and proteins consist almost exclusively of linear or cyclic polypeptide chains. Our group explores the chemical space of peptides by redesigning their topology through the introduction of branching points in the peptide chain. Branched peptides are generally
resistant to proteolysis and display remarkable biological properties by multivalency effects (peptide dendrimers) and conformational rigidity (polycyclic peptides). We review our recent progress in peptide dendrimers as enzyme models, biofilm inhibitors, antimicrobials, DNA transfection and
cell-penetrating agents, and in the synthesis and characterization of bicyclic peptides as new scaffolds for drug design.
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| first_indexed | 2024-12-13T03:36:56Z |
| format | Article |
| id | doaj.art-a9729641226f4200802a3950a1d52581 |
| institution | Directory Open Access Journal |
| issn | 0009-4293 2673-2424 |
| language | deu |
| last_indexed | 2024-12-13T03:36:56Z |
| publishDate | 2013-12-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj.art-a9729641226f4200802a3950a1d525812022-12-22T00:01:01ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24242013-12-01671210.2533/chimia.2013.864Expanding the Topological Space of Bioactive PeptidesJean-Louis Reymond0Tamis DarbreDepartment of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH-3012 Bern, Switzerland Naturally occurring peptides and proteins consist almost exclusively of linear or cyclic polypeptide chains. Our group explores the chemical space of peptides by redesigning their topology through the introduction of branching points in the peptide chain. Branched peptides are generally resistant to proteolysis and display remarkable biological properties by multivalency effects (peptide dendrimers) and conformational rigidity (polycyclic peptides). We review our recent progress in peptide dendrimers as enzyme models, biofilm inhibitors, antimicrobials, DNA transfection and cell-penetrating agents, and in the synthesis and characterization of bicyclic peptides as new scaffolds for drug design. https://www.chimia.ch/chimia/article/view/5484Bioactive peptides |
| spellingShingle | Jean-Louis Reymond Tamis Darbre Expanding the Topological Space of Bioactive Peptides CHIMIA Bioactive peptides |
| title | Expanding the Topological Space of Bioactive Peptides |
| title_full | Expanding the Topological Space of Bioactive Peptides |
| title_fullStr | Expanding the Topological Space of Bioactive Peptides |
| title_full_unstemmed | Expanding the Topological Space of Bioactive Peptides |
| title_short | Expanding the Topological Space of Bioactive Peptides |
| title_sort | expanding the topological space of bioactive peptides |
| topic | Bioactive peptides |
| url | https://www.chimia.ch/chimia/article/view/5484 |
| work_keys_str_mv | AT jeanlouisreymond expandingthetopologicalspaceofbioactivepeptides AT tamisdarbre expandingthetopologicalspaceofbioactivepeptides |