Genetic characterisation of 19 autosomal STR loci in a population sample from the Southeastern Anatolia Region of Turkey

Background: Southeastern Anatolia is the smallest, yet the most densely populated region among the seven major geographic constituents of Turkey. Situated in the Upper Mesopotamia, Southeastern Anatolia was also the northernmost extension of the Fertile Crescent, which is often considered as the ear...

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Main Authors: Nazli Bozman, Cemal Gurkan, Huseyin Sevay, Damla Kanliada Demirdov, Filiz Ozbas-Gerceker
Format: Article
Language:English
Published: Taylor & Francis Group 2018-02-01
Series:Annals of Human Biology
Subjects:
Online Access:http://dx.doi.org/10.1080/03014460.2018.1444202
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author Nazli Bozman
Cemal Gurkan
Huseyin Sevay
Damla Kanliada Demirdov
Filiz Ozbas-Gerceker
author_facet Nazli Bozman
Cemal Gurkan
Huseyin Sevay
Damla Kanliada Demirdov
Filiz Ozbas-Gerceker
author_sort Nazli Bozman
collection DOAJ
description Background: Southeastern Anatolia is the smallest, yet the most densely populated region among the seven major geographic constituents of Turkey. Situated in the Upper Mesopotamia, Southeastern Anatolia was also the northernmost extension of the Fertile Crescent, which is often considered as the earliest cradle of civilisation. Aim: To investigate the autosomal STR polymorphisms associated with a truly representative population sample pool from Southeastern Anatolia. Subjects and methods: Samples from a total of 257 volunteers were analysed by 19-loci autosomal STRs using the commercially available COrDIS Plus Kit. Allele frequencies, statistical parameters of forensic interest and Nei’s DA distances with respect to the nearby and distant populations were calculated, besides performing exact tests of population differentiation with the same populations. Results: A combined matching probability of 1.49978 × 10−23 and a combined power of exclusion of 0.999999961 were obtained for the novel Southeastern Anatolian autosomal STR dataset. Furthermore, the Southeastern Anatolia population was found to have close genetic affinities with the other regional populations from Turkey, along with those from an apparent genetic continuum extending from the Near East to Southeastern Europe. Conclusions: The novel Southeastern Anatolian dataset is expected to be useful in regional forensic genetics investigations and molecular anthropology applications.
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spelling doaj.art-a97463f780f14283959b48c76c37fc922023-09-14T15:36:09ZengTaylor & Francis GroupAnnals of Human Biology0301-44601464-50332018-02-0145214815910.1080/03014460.2018.14442021444202Genetic characterisation of 19 autosomal STR loci in a population sample from the Southeastern Anatolia Region of TurkeyNazli Bozman0Cemal Gurkan1Huseyin Sevay2Damla Kanliada Demirdov3Filiz Ozbas-Gerceker4University of GaziantepCommittee on Missing Persons in Cyprus Turkish Cypriot Member OfficeNear East UniversityCommittee on Missing Persons in Cyprus Turkish Cypriot Member OfficeUniversity of GaziantepBackground: Southeastern Anatolia is the smallest, yet the most densely populated region among the seven major geographic constituents of Turkey. Situated in the Upper Mesopotamia, Southeastern Anatolia was also the northernmost extension of the Fertile Crescent, which is often considered as the earliest cradle of civilisation. Aim: To investigate the autosomal STR polymorphisms associated with a truly representative population sample pool from Southeastern Anatolia. Subjects and methods: Samples from a total of 257 volunteers were analysed by 19-loci autosomal STRs using the commercially available COrDIS Plus Kit. Allele frequencies, statistical parameters of forensic interest and Nei’s DA distances with respect to the nearby and distant populations were calculated, besides performing exact tests of population differentiation with the same populations. Results: A combined matching probability of 1.49978 × 10−23 and a combined power of exclusion of 0.999999961 were obtained for the novel Southeastern Anatolian autosomal STR dataset. Furthermore, the Southeastern Anatolia population was found to have close genetic affinities with the other regional populations from Turkey, along with those from an apparent genetic continuum extending from the Near East to Southeastern Europe. Conclusions: The novel Southeastern Anatolian dataset is expected to be useful in regional forensic genetics investigations and molecular anthropology applications.http://dx.doi.org/10.1080/03014460.2018.1444202upper mesopotamiacordis plusturkishforensicpopulation genetics
spellingShingle Nazli Bozman
Cemal Gurkan
Huseyin Sevay
Damla Kanliada Demirdov
Filiz Ozbas-Gerceker
Genetic characterisation of 19 autosomal STR loci in a population sample from the Southeastern Anatolia Region of Turkey
Annals of Human Biology
upper mesopotamia
cordis plus
turkish
forensic
population genetics
title Genetic characterisation of 19 autosomal STR loci in a population sample from the Southeastern Anatolia Region of Turkey
title_full Genetic characterisation of 19 autosomal STR loci in a population sample from the Southeastern Anatolia Region of Turkey
title_fullStr Genetic characterisation of 19 autosomal STR loci in a population sample from the Southeastern Anatolia Region of Turkey
title_full_unstemmed Genetic characterisation of 19 autosomal STR loci in a population sample from the Southeastern Anatolia Region of Turkey
title_short Genetic characterisation of 19 autosomal STR loci in a population sample from the Southeastern Anatolia Region of Turkey
title_sort genetic characterisation of 19 autosomal str loci in a population sample from the southeastern anatolia region of turkey
topic upper mesopotamia
cordis plus
turkish
forensic
population genetics
url http://dx.doi.org/10.1080/03014460.2018.1444202
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