Circulating Neurofilament Light Predicts Cognitive Decline in Patients With Post-stroke Subjective Cognitive Impairment
BackgroundSubjective cognitive impairment (SCI) is common after acute ischemic stroke and adversely affects the quality of life. SCI is associated with an increased risk of developing mild cognitive impairment and dementia. Identifying biomarkers which could predict long-term cognitive outcomes of p...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-05-01
|
| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2021.665981/full |
| _version_ | 1818455400793505792 |
|---|---|
| author | Jian-Hong Wang Jie Huang Fu-Qiang Guo Fang Wang Shu Yang Neng-Wei Yu Bo Zheng Jian Wang |
| author_facet | Jian-Hong Wang Jie Huang Fu-Qiang Guo Fang Wang Shu Yang Neng-Wei Yu Bo Zheng Jian Wang |
| author_sort | Jian-Hong Wang |
| collection | DOAJ |
| description | BackgroundSubjective cognitive impairment (SCI) is common after acute ischemic stroke and adversely affects the quality of life. SCI is associated with an increased risk of developing mild cognitive impairment and dementia. Identifying biomarkers which could predict long-term cognitive outcomes of post-stroke SCI is of importance for early intervention. This study aims to investigate the association between circulating neurofilament light (NfL) and long-term cognitive function in patients with post-stroke SCI.MethodsThis longitudinal study recruited 304 patients with post-stroke SCI, and serum NfL levels were determined at baseline. These patients were followed up for 12 months for the observation of cognitive change. Cognitive performances were assessed by a Chinese version of the Telephone Interview of Cognitive Status-40 (TICS-40) scale.ResultsThe patients were divided into a progression group (as determined by decreased TICS-40 scores) and a stable group (as determined by increased or unchanged TICS-40 scores). The progression group had significantly higher serum NfL levels than the stable group at baseline. Serum NfL levels were predictive for longitudinal cognitive decline during follow-up.ConclusionThese findings imply that circulating NfL could predict the long-term cognitive change of patients with post-stroke SCI. |
| first_indexed | 2024-12-14T22:10:11Z |
| format | Article |
| id | doaj.art-a97512fd96364539ad96cc15c4c3e6d5 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-14T22:10:11Z |
| publishDate | 2021-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-a97512fd96364539ad96cc15c4c3e6d52022-12-21T22:45:46ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652021-05-011310.3389/fnagi.2021.665981665981Circulating Neurofilament Light Predicts Cognitive Decline in Patients With Post-stroke Subjective Cognitive ImpairmentJian-Hong Wang0Jie Huang1Fu-Qiang Guo2Fang Wang3Shu Yang4Neng-Wei Yu5Bo Zheng6Jian Wang7Department of Neurology, The Affiliated Hospital of University of Electronic Science and Technology, Sichuan Provincial People’s Hospital, Chengdu, ChinaDepartment of Neurology, The Affiliated Hospital of University of Electronic Science and Technology, Sichuan Provincial People’s Hospital, Chengdu, ChinaDepartment of Neurology, The Affiliated Hospital of University of Electronic Science and Technology, Sichuan Provincial People’s Hospital, Chengdu, ChinaInnovation Center of Nursing Research, West China Hospital, Nursing Key Laboratory of Sichuan Province, Sichuan University, Chengdu, ChinaDepartment of Neurology, The Affiliated Hospital of University of Electronic Science and Technology, Sichuan Provincial People’s Hospital, Chengdu, ChinaDepartment of Neurology, The Affiliated Hospital of University of Electronic Science and Technology, Sichuan Provincial People’s Hospital, Chengdu, ChinaDepartment of Neurology, Ya’an People’s Hospital, Ya’an, ChinaDepartment of Neurology, Ya’an People’s Hospital, Ya’an, ChinaBackgroundSubjective cognitive impairment (SCI) is common after acute ischemic stroke and adversely affects the quality of life. SCI is associated with an increased risk of developing mild cognitive impairment and dementia. Identifying biomarkers which could predict long-term cognitive outcomes of post-stroke SCI is of importance for early intervention. This study aims to investigate the association between circulating neurofilament light (NfL) and long-term cognitive function in patients with post-stroke SCI.MethodsThis longitudinal study recruited 304 patients with post-stroke SCI, and serum NfL levels were determined at baseline. These patients were followed up for 12 months for the observation of cognitive change. Cognitive performances were assessed by a Chinese version of the Telephone Interview of Cognitive Status-40 (TICS-40) scale.ResultsThe patients were divided into a progression group (as determined by decreased TICS-40 scores) and a stable group (as determined by increased or unchanged TICS-40 scores). The progression group had significantly higher serum NfL levels than the stable group at baseline. Serum NfL levels were predictive for longitudinal cognitive decline during follow-up.ConclusionThese findings imply that circulating NfL could predict the long-term cognitive change of patients with post-stroke SCI.https://www.frontiersin.org/articles/10.3389/fnagi.2021.665981/fullacute ischemic strokeneurofilament lightbiomarkerprognosissubjective cognitive impairment (SCI) |
| spellingShingle | Jian-Hong Wang Jie Huang Fu-Qiang Guo Fang Wang Shu Yang Neng-Wei Yu Bo Zheng Jian Wang Circulating Neurofilament Light Predicts Cognitive Decline in Patients With Post-stroke Subjective Cognitive Impairment Frontiers in Aging Neuroscience acute ischemic stroke neurofilament light biomarker prognosis subjective cognitive impairment (SCI) |
| title | Circulating Neurofilament Light Predicts Cognitive Decline in Patients With Post-stroke Subjective Cognitive Impairment |
| title_full | Circulating Neurofilament Light Predicts Cognitive Decline in Patients With Post-stroke Subjective Cognitive Impairment |
| title_fullStr | Circulating Neurofilament Light Predicts Cognitive Decline in Patients With Post-stroke Subjective Cognitive Impairment |
| title_full_unstemmed | Circulating Neurofilament Light Predicts Cognitive Decline in Patients With Post-stroke Subjective Cognitive Impairment |
| title_short | Circulating Neurofilament Light Predicts Cognitive Decline in Patients With Post-stroke Subjective Cognitive Impairment |
| title_sort | circulating neurofilament light predicts cognitive decline in patients with post stroke subjective cognitive impairment |
| topic | acute ischemic stroke neurofilament light biomarker prognosis subjective cognitive impairment (SCI) |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2021.665981/full |
| work_keys_str_mv | AT jianhongwang circulatingneurofilamentlightpredictscognitivedeclineinpatientswithpoststrokesubjectivecognitiveimpairment AT jiehuang circulatingneurofilamentlightpredictscognitivedeclineinpatientswithpoststrokesubjectivecognitiveimpairment AT fuqiangguo circulatingneurofilamentlightpredictscognitivedeclineinpatientswithpoststrokesubjectivecognitiveimpairment AT fangwang circulatingneurofilamentlightpredictscognitivedeclineinpatientswithpoststrokesubjectivecognitiveimpairment AT shuyang circulatingneurofilamentlightpredictscognitivedeclineinpatientswithpoststrokesubjectivecognitiveimpairment AT nengweiyu circulatingneurofilamentlightpredictscognitivedeclineinpatientswithpoststrokesubjectivecognitiveimpairment AT bozheng circulatingneurofilamentlightpredictscognitivedeclineinpatientswithpoststrokesubjectivecognitiveimpairment AT jianwang circulatingneurofilamentlightpredictscognitivedeclineinpatientswithpoststrokesubjectivecognitiveimpairment |