Formulation and In-Vitro Characterization of Chitosan-Nanoparticles Loaded with the Iron Chelator Deferoxamine Mesylate (DFO)

Formulation and In-Vitro Characterization of Chitosan-Nanoparticles Loaded with the Iron Chelator Deferoxamine Mesylate (DFO)

The objective of this study was to develop chitosan (CS) nanoparticles (NPs) loaded with deferoxamine mesylate (DFO) for slow release of this iron-chelating drug. Drug nanoencapsulation was performed via ionic gelation of chitosan using sodium tripolyphosphate (TPP) as cross-linker. Nanoparticles wi...

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Bibliographic Details
Main Authors: Maria Lazaridou, Evi Christodoulou, Maria Nerantzaki, Margaritis Kostoglou, Dimitra A. Lambropoulou, Angeliki Katsarou, Kostas Pantopoulos, Dimitrios N. Bikiaris
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Pharmaceutics
Subjects:
chitosan
nanoparticles
ionic gelation
tripolyphosphate
deferoxamine mesylate
iron chelator
nanoencapsulation
drug release
Online Access:https://www.mdpi.com/1999-4923/12/3/238

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https://www.mdpi.com/1999-4923/12/3/238

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