Effect of exogenous leptin on serum levels of lipids, glucose, renal and hepatic variables in both genders of obese and streptozotocin-induced diabetic rats
Objective(s): Leptin exerts various effects on appetite and body weight. Disruption of the obesitygene is precedent to fatness. Insulin or glucose elevates leptin, but streptozotocin reduces it. However, controversial data exist for the effects of leptin on diabetes and leptin level in each gender....
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2015-11-01
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| Series: | Iranian Journal of Basic Medical Sciences |
| Subjects: | |
| Online Access: | http://ijbms.mums.ac.ir/pdf_6044_fd2fa18ecca603b23a4d8568aff3478a.html |
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| author | Parichehr Hayatdavoudi Mohsen Ghasemi Bamdad Zendehbad Mohammad Soukhtanloo Alireza Golshan Mousa Al-Reza Hadjzadeh |
| author_facet | Parichehr Hayatdavoudi Mohsen Ghasemi Bamdad Zendehbad Mohammad Soukhtanloo Alireza Golshan Mousa Al-Reza Hadjzadeh |
| author_sort | Parichehr Hayatdavoudi |
| collection | DOAJ |
| description | Objective(s): Leptin exerts various effects on appetite and body weight. Disruption of the obesitygene is precedent to fatness. Insulin or glucose elevates leptin, but streptozotocin reduces it. However, controversial data exist for the effects of leptin on diabetes and leptin level in each gender. Leptin can damage the kidney function but little evidence exists for its hepatic effects. The aim of this study was to investigate the probable sex-dependent differences in blood sugar levels, lipid profile, and renal and hepatic biochemical factors in the obesity and streptozotocin-induced diabetic rats after leptin administration. Materials and Methods: Wistar rats of both sexes were randomly divided into two groups, namely obese and diabetic rats. Each group was further divided into male and female subgroups. Extra fat and carbohydrate was added to the diet to induce obesity. Furthermore, streptozotocin (55 mg/kg, IP) was injected to induce diabetes. The treatment groups received leptin (0.1 mg/kg SC) for 10 days, and then, blood samples were taken from the orbital sinus for laboratory evaluations. Results: Leptin resulted in a significant weight loss in both sexes (P |
| first_indexed | 2024-12-20T00:42:07Z |
| format | Article |
| id | doaj.art-a977463f0cd740708b2315885aa48975 |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-12-20T00:42:07Z |
| publishDate | 2015-11-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-a977463f0cd740708b2315885aa489752022-12-21T19:59:31ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742015-11-011811107210786044Effect of exogenous leptin on serum levels of lipids, glucose, renal and hepatic variables in both genders of obese and streptozotocin-induced diabetic ratsParichehr Hayatdavoudi0Mohsen Ghasemi1Bamdad Zendehbad2Mohammad Soukhtanloo3Alireza Golshan4Mousa Al-Reza Hadjzadeh5Neurogenic Inflammation Research center, Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranFaculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, IranNeurogenic Inflammation Research center, Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Medical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranFaculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, IranNeurocognitive Research Center, Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranObjective(s): Leptin exerts various effects on appetite and body weight. Disruption of the obesitygene is precedent to fatness. Insulin or glucose elevates leptin, but streptozotocin reduces it. However, controversial data exist for the effects of leptin on diabetes and leptin level in each gender. Leptin can damage the kidney function but little evidence exists for its hepatic effects. The aim of this study was to investigate the probable sex-dependent differences in blood sugar levels, lipid profile, and renal and hepatic biochemical factors in the obesity and streptozotocin-induced diabetic rats after leptin administration. Materials and Methods: Wistar rats of both sexes were randomly divided into two groups, namely obese and diabetic rats. Each group was further divided into male and female subgroups. Extra fat and carbohydrate was added to the diet to induce obesity. Furthermore, streptozotocin (55 mg/kg, IP) was injected to induce diabetes. The treatment groups received leptin (0.1 mg/kg SC) for 10 days, and then, blood samples were taken from the orbital sinus for laboratory evaluations. Results: Leptin resulted in a significant weight loss in both sexes (Phttp://ijbms.mums.ac.ir/pdf_6044_fd2fa18ecca603b23a4d8568aff3478a.htmlDiabetes mellitus type 1GlucoseLeptinLDL cholesterolRat |
| spellingShingle | Parichehr Hayatdavoudi Mohsen Ghasemi Bamdad Zendehbad Mohammad Soukhtanloo Alireza Golshan Mousa Al-Reza Hadjzadeh Effect of exogenous leptin on serum levels of lipids, glucose, renal and hepatic variables in both genders of obese and streptozotocin-induced diabetic rats Iranian Journal of Basic Medical Sciences Diabetes mellitus type 1 Glucose Leptin LDL cholesterol Rat |
| title | Effect of exogenous leptin on serum levels of lipids, glucose, renal and hepatic variables in both genders of obese and streptozotocin-induced diabetic rats |
| title_full | Effect of exogenous leptin on serum levels of lipids, glucose, renal and hepatic variables in both genders of obese and streptozotocin-induced diabetic rats |
| title_fullStr | Effect of exogenous leptin on serum levels of lipids, glucose, renal and hepatic variables in both genders of obese and streptozotocin-induced diabetic rats |
| title_full_unstemmed | Effect of exogenous leptin on serum levels of lipids, glucose, renal and hepatic variables in both genders of obese and streptozotocin-induced diabetic rats |
| title_short | Effect of exogenous leptin on serum levels of lipids, glucose, renal and hepatic variables in both genders of obese and streptozotocin-induced diabetic rats |
| title_sort | effect of exogenous leptin on serum levels of lipids glucose renal and hepatic variables in both genders of obese and streptozotocin induced diabetic rats |
| topic | Diabetes mellitus type 1 Glucose Leptin LDL cholesterol Rat |
| url | http://ijbms.mums.ac.ir/pdf_6044_fd2fa18ecca603b23a4d8568aff3478a.html |
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