Biased signaling due to oligomerization of the G protein-coupled platelet-activating factor receptor
The functional consequence of G protein-coupled receptor oligomerization remains debated. Here the authors show that platelet-activating factor receptor oligomerization enhances G protein coupling, and restrains β-arrestin recruitment and internalization.
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34056-4 |
| _version_ | 1811257212080750592 |
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| author | Junke Liu Hengmin Tang Chanjuan Xu Shengnan Zhou Xunying Zhu Yuanyuan Li Laurent Prézeau Tao Xu Jean-Philippe Pin Philippe Rondard Wei Ji Jianfeng Liu |
| author_facet | Junke Liu Hengmin Tang Chanjuan Xu Shengnan Zhou Xunying Zhu Yuanyuan Li Laurent Prézeau Tao Xu Jean-Philippe Pin Philippe Rondard Wei Ji Jianfeng Liu |
| author_sort | Junke Liu |
| collection | DOAJ |
| description | The functional consequence of G protein-coupled receptor oligomerization remains debated. Here the authors show that platelet-activating factor receptor oligomerization enhances G protein coupling, and restrains β-arrestin recruitment and internalization. |
| first_indexed | 2024-04-12T17:53:00Z |
| format | Article |
| id | doaj.art-a97813f6a8c84e5398c5ec28ca06bef1 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T17:53:00Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a97813f6a8c84e5398c5ec28ca06bef12022-12-22T03:22:26ZengNature PortfolioNature Communications2041-17232022-10-0113111610.1038/s41467-022-34056-4Biased signaling due to oligomerization of the G protein-coupled platelet-activating factor receptorJunke Liu0Hengmin Tang1Chanjuan Xu2Shengnan Zhou3Xunying Zhu4Yuanyuan Li5Laurent Prézeau6Tao Xu7Jean-Philippe Pin8Philippe Rondard9Wei Ji10Jianfeng Liu11Cellular Signaling laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, College of Life Science and Technology, Huazhong University of Science and TechnologyCellular Signaling laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, College of Life Science and Technology, Huazhong University of Science and TechnologyCellular Signaling laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, College of Life Science and Technology, Huazhong University of Science and TechnologyCellular Signaling laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, College of Life Science and Technology, Huazhong University of Science and TechnologyCellular Signaling laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, College of Life Science and Technology, Huazhong University of Science and TechnologyNational Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesInstitut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERMNational Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesInstitut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERMInstitut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERMNational Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesCellular Signaling laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, College of Life Science and Technology, Huazhong University of Science and TechnologyThe functional consequence of G protein-coupled receptor oligomerization remains debated. Here the authors show that platelet-activating factor receptor oligomerization enhances G protein coupling, and restrains β-arrestin recruitment and internalization.https://doi.org/10.1038/s41467-022-34056-4 |
| spellingShingle | Junke Liu Hengmin Tang Chanjuan Xu Shengnan Zhou Xunying Zhu Yuanyuan Li Laurent Prézeau Tao Xu Jean-Philippe Pin Philippe Rondard Wei Ji Jianfeng Liu Biased signaling due to oligomerization of the G protein-coupled platelet-activating factor receptor Nature Communications |
| title | Biased signaling due to oligomerization of the G protein-coupled platelet-activating factor receptor |
| title_full | Biased signaling due to oligomerization of the G protein-coupled platelet-activating factor receptor |
| title_fullStr | Biased signaling due to oligomerization of the G protein-coupled platelet-activating factor receptor |
| title_full_unstemmed | Biased signaling due to oligomerization of the G protein-coupled platelet-activating factor receptor |
| title_short | Biased signaling due to oligomerization of the G protein-coupled platelet-activating factor receptor |
| title_sort | biased signaling due to oligomerization of the g protein coupled platelet activating factor receptor |
| url | https://doi.org/10.1038/s41467-022-34056-4 |
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