Biased signaling due to oligomerization of the G protein-coupled platelet-activating factor receptor

Biased signaling due to oligomerization of the G protein-coupled platelet-activating factor receptor

The functional consequence of G protein-coupled receptor oligomerization remains debated. Here the authors show that platelet-activating factor receptor oligomerization enhances G protein coupling, and restrains β-arrestin recruitment and internalization.

Bibliographic Details
Main Authors: Junke Liu, Hengmin Tang, Chanjuan Xu, Shengnan Zhou, Xunying Zhu, Yuanyuan Li, Laurent Prézeau, Tao Xu, Jean-Philippe Pin, Philippe Rondard, Wei Ji, Jianfeng Liu
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34056-4

Internet

https://doi.org/10.1038/s41467-022-34056-4

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